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C A González,
F Megraud,
A Buissonniere,
L Lujan Barroso,
A Agudo,
E J Duell,
M C Boutron-Ruault,
F Clavel-Chapelon,
D Palli,
V Krogh, [......],
K Bakken,
V Dumeaux,
E Lund,
M Jenab,
I Romieu,
D Michaud,
T Mouw,
F Carneiro,
C Fenge,
E Riboli
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[hide abstract]
ABSTRACT: In epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection.
In a nested case-control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII(®)).
By immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G positive versus negative by ELISA was 6.8 [95% confidence interval (CI) 3.0-15.1], and by immunoblot, the OR was 21.4 (95% CI 7.1-64.4).
Using a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC.
Annals of Oncology 09/2011; 23(5):1320-4. · 6.43 Impact Factor
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K K Tsilidis,
N E Allen,
T J Key,
L Dossus,
A Lukanova,
K Bakken,
E Lund,
A Fournier,
K Overvad,
L Hansen, [......],
N Larrañaga,
K Jirström,
J Manjer,
A Idahl,
N Ohlson,
K-T Khaw,
N Wareham,
T Mouw,
T Norat,
E Riboli
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ABSTRACT: It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear.
We examined the associations of oral contraceptive use and reproductive factors with ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 327,396 eligible women, 878 developed ovarian cancer over an average of 9 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre and age, and adjusted for smoking status, body mass index, unilateral ovariectomy, simple hysterectomy, menopausal hormone therapy, and mutually adjusted for age at menarche, age at menopause, number of full-term pregnancies and duration of oral contraceptive use.
Women who used oral contraceptives for 10 or more years had a significant 45% (HR, 0.55; 95% CI, 0.41-0.75) lower risk compared with users of 1 year or less (P-trend, <0.01). Compared with nulliparous women, parous women had a 29% (HR, 0.71; 95% CI, 0.59-0.87) lower risk, with an 8% reduction in risk for each additional pregnancy. A high age at menopause was associated with a higher risk of ovarian cancer (>52 vs ≤ 45 years: HR, 1.46; 95% CI, 1.06-1.99; P-trend, 0.02). Age at menarche, age at first full-term pregnancy, incomplete pregnancies and breastfeeding were not associated with risk.
This study shows a strong protective association of oral contraceptives and parity with ovarian cancer risk, a higher risk with a late age at menopause, and no association with other reproductive factors.
British Journal of Cancer 09/2011; 105(9):1436-42. · 5.04 Impact Factor
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K K Tsilidis,
N E Allen,
T J Key,
K Bakken,
E Lund,
F Berrino,
A Fournier,
A Olsen,
A Tj|[oslash]|nneland,
K Overvad, [......],
M Dorronsoro,
S Borgquist,
J Manjer,
B van Guelpen,
G Hallmans,
S A Rodwell,
K-T Khaw,
T Norat,
D Romaguera,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: Background: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk.
British Journal of Cancer 11/2010; 103(11):1755-1759. · 5.04 Impact Factor
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K K Tsilidis,
N E Allen,
T J Key,
K Bakken,
E Lund,
F Berrino,
A Fournier,
A Olsen,
A Tjønneland,
K Overvad, [......],
M Dorronsoro,
S Borgquist,
J Manjer,
B van Guelpen,
G Hallmans,
S A Rodwell,
K-T Khaw,
T Norat,
D Romaguera,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk.
We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337,802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer.
After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk.
Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk.
British Journal of Cancer 11/2010; 103(11):1755-9. · 5.04 Impact Factor
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N.E. Allen, K.K. Tsilidis,
T.J. Key,
L. Dossus,
R. Kaaks,
E Lund,
K Bakken,
O. Gavrilyuk,
K. Overvad,
A. Tjonneland, [......],
R. Tumino,
S Panico,
M Bergmann,
M. Schuetze,
F.J.B van Duijnhoven,
H.B. Bueno-de-Mesquita,
N.C. Onland-Moret,
C.H. van Gils,
X et al,
E Riboli
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E.J. Duell,
N. Travier,
L Lujan Barroso,
M.C. Boutron-Ruault,
F. Clavel-Chapelon,
D Palli,
V Krogh,
A. Mattiello,
R. Tumino,
C. Sacerdote, [......],
N Wareham,
N.E. Allen, K.K. Tsilidis,
H.B. Bueno-de-Mesquita,
M.E. Numans,
P.H.M. Peeters,
S M Jeurnink,
P Lagiou,
E. Valanou,
C.A. Gonzalez
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K.K. Tsilidis,
N.E. Allen,
T.J. Key,
K Bakken,
E Lund,
F Berrino,
A Fournier,
A. Olsen,
A. Tjonneland,
K. Overvad, [......],
M Bergmann,
H Boeing,
Y Koumantaki,
G. Stasinopoulou,
A Trichopoulou,
D Palli,
F.J.B van Duijnhoven,
C.H. van Gils,
P.H.M. Peeters,
E Riboli
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D S Michaud,
V Gallo,
B Schlehofer,
A. Tjonneland,
A. Olsen,
K. Overvad,
C. Dahm,
R. Kaaks,
A Lukanova,
H Boeing, [......],
J. Manjer,
S Borgquist,
K T Khaw,
N Wareham,
N.E. Allen, K.K. Tsilidis,
I Romieu,
S Rinaldi,
P Vineis,
E Riboli
