Kirti S Prabhu

Manipal University, Udupi, Karnātaka, India

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Publications (8)7.83 Total impact

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    ABSTRACT: Curcuma longa Linn., commonly known as Turmeric, Indian saffron or Haldi belongs to family Zingiberaceae., is a perennial herb with simple and large leaves. Its tubers, rhizomes and oil have great importance. Melaleuca alternifolia commonly known as tea tree oil, belonging to the family myrtaceae, has been used as a botanical medicine in various forms over the centuries for its antibacterial activity. In this study a cream have been formulated using vanishing cream base incorporating Curcuma longa ethanol extract and tea tree oil in different ratio. The formulated creams were tested for their microbicidal activity against various skin pathogens viz. Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC25354), Staphylococcus epidermis (ATCC 12228), Propionibacterium acne (ATCC 6919), Candida albicans (ATCC 36232), Methicillin Resistant Staphylococcus aureus (MRSA) (Clinical isolate), Methicillin Susceptible Staphylococcus aureus (MSSA) (Clinical isolate). The formulated creams showed excellent microbicidal activity against all the pathogens used in the test.
    Journal of Biologically Active Products from Nature. 01/2011; 1(1).
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    ABSTRACT: Aloe vera gel is a familiar ingredient in a range of widely available and advertisement healthcare and cosmetic products. As to date there are no documented reports on the standardization of A. vera gel and the following study is an attempt in this direction. A. vera gel was evaluated for its aloeverose content for the first time. Aloeverose, was separated on a thin-layer of silica gel by isocratic gradient elution technique was determined by using HPTLC-photodensitometry. The proposed method is simple and sensitive and can be used for the routine assay of aloeverose in phytomedicines containing A. vera gel.
    Fitoterapia 09/2009; 81(4):231-3. · 2.23 Impact Factor
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    ABSTRACT: Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology. Research carried out using different in-vitro and in-vivo techniques of biological evaluation supports most of the claims. This review presents the botany, chemistry, traditional uses and pharmacological data of the plant.
    Journal of Pharmacy and Pharmacology 02/2009; 61(1):13-21. · 2.03 Impact Factor
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    K S Prabhu, R Lobo, A A Shirwaikar
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    ABSTRACT: Ocimum gratissimum is a well-known plant used in the Indian system of medicine. Folklore medicine claims its use in headache, fever, diarrhoea, pneumonia etc. Research carried out using different in vitro and in vivo techniques of biological evaluation supports most of the claims. This review presents the ethnobotanical, natural product chemistry, pharmacological, clinical and toxicological data of the plant.
    01/2009; 1:1-15.
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    ABSTRACT: Fungal infections of skin are one of the most common infections in human beings. The areas which are likely to get infected include the scalp, the hands and the feet. Dermatophytes, yeasts and moulds are the three major fungi responsible for skin infections. Earlier oral antifungal agents were used for treatment of fungal infection in finger and toe nails. The disadvantages of oral antifungal agents are toxicity and longer treatment period. Now medicated nail lacquers have been developed for the treatment of fungal infections i.e. onychomycosis, which has less toxicity and shorter treatment period.
    Indian Journal of Pharmaceutical Sciences 11/2008; 70(6):710-4. · 0.34 Impact Factor
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    Kirti S Prabhu, Richard Lobo, Annie Shirwaikar
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    ABSTRACT: We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mgkg(-1) i.p.) and streptozotocin (STZ) (60 mgkg(-1) i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test. Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.
    Journal of Pharmacy and Pharmacology 08/2008; 60(7):909-16. · 2.03 Impact Factor
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    Annie Shirwaikar, Kirti S Prabhu, I S R Punitha
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    ABSTRACT: The free radical scavenging potential of the plant S. indicus was studied by using different antioxidant models of screening. The ethanolic extract at 1000 microg/ml showed maximum scavenging of the radical cation, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 41.99% followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (DPPH) (33.27%), superoxide dismutase (25.14%) and nitric oxide radical (22.36%) at the same concentration. However, the extract showed only moderate scavenging activity of iron chelation (14.2%). Total antioxidant capacity of the extract was found to be 160.85 nmol/g ascorbic acid. The results justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.
    Indian journal of experimental biology 01/2007; 44(12):993-6. · 1.20 Impact Factor
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    ABSTRACT: Dendrophthoe falcata is a parasitic plant used in traditional medicine as an aphrodisiac, astringent, and diuretic and for pulmonary tuberculosis, asthma, menstrual disorder, swelling, and wound. The present study primarily describes the antioxidant activities of methanolic and aqueous extracts of the stem of D. falcate in different in vitro models. Both methanolic and aqueous extracts exhibited antioxidant activity, with IC 50 values at 18 and 26 g/mL for DPPH, 22 and 29 g/mL for ABTS, 62 and 75 g/mL for NO scavenging activities, 260 and 180 g/mL for total antioxidant capacity, re-spectively. Total phenolic content for methanolic and aqueous extracts were found to be 1.5 and 1.1 mg/g while total fla-vonoid content were found to be 0.140 and 0.029 mg/g. The overall antioxidant activity might be attributed to its poly-phenolic, flavonoid and phytosterol constituents.