Publications (11)11.51 Total impact
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Article: Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept.
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ABSTRACT: To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid-term fetuses at 6-9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentin-negative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 11/2012; · 1.47 Impact Factor -
Article: Immediate semi-static loading using compression healing abutments: a stability study in dogs.
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ABSTRACT: Loading in implant dentistry to accelerate prosthodontic treatment has been receiving increasing interest. The aim of this study was to investigate the effect of an early controlled lateral loading (after 7 days) on the establishment of osseointegration by means of resonance frequency analysis. Two groups of six beagle dogs each were used. Group I had implants without loading. Group II had implants loaded with a new prototype compression abutment that created controlled semi-static loading. Loaded implants showed slightly better stability after 5 weeks of healing, but the difference was not significant. We concluded that controlled loading is beneficial to maintain, and even improve, stability during the early critical healing period.Research in Veterinary Science 09/2011; 93(1):484-7. · 1.65 Impact Factor -
Article: Glandular odontogenic cyst: two high-risk cases treated with conservative approaches.
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ABSTRACT: The glandular odontogenic cyst is a rare jawbone cyst that is considered to be an independent entity, although its histopathological characteristics may lead to an incorrect diagnosis as a low-grade mucoepidermoid carcinoma. The treatment of glandular odontogenic cysts is controversial. We present two high-risk cases treated with conservative approaches, one by enucleation and curettage and the other by marsupialisation. This report also presents a review of the clinical and pathological aspects of glandular odontogenic cysts, and considers their development. No evidence of disease was observed after 3 years of follow-up in the two cases presented. When possible, treatment plans for these lesions should be customised for each case, taking into account the data available in the literature and patient preferences. For high-risk cases, that are treated with conservative approaches, such as the two cases presented here, strict and regular controls and rigorous radiological follow-up evaluations are mandatory.Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 08/2011; 40(5):e131-6. · 1.25 Impact Factor -
Article: Closure of the middle ear with special reference to the development of the tegmen tympani of the temporal bone.
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ABSTRACT: Closure of the middle ear is believed to be closely related to the evolutionary development of the mammalian jaw. However, few comprehensive descriptions are available on fetal development. We examined paraffin-embedded specimens of 20 mid-term human fetuses at 8-25 weeks of ovulation age (crown-rump length or CRL, 38-220 mm). After 9 weeks, the tympanic bone and the squamous part of the temporal bone, each of which was cranial or caudal to Meckel's cartilage, grew to close the lateral part of the tympanosquamosal fissure. At the same time, the cartilaginous tegmen tympani appeared independently of the petrous part of the temporal bone and resulted in the petrosquamosal fissure. Subsequently, the medial part of the tympanosquamosal fissure was closed by the descent of a cartilaginous inferior process of the tegmen tympani. When Meckel's cartilage changed into the sphenomandibular ligament and the anterior ligament of the malleus, the inferior process of the tegmen tympani interposed between the tympanic bone and the squamous part of the temporal bone, forming the petrotympanic fissure for the chorda tympani nerve and the discomalleolar ligament. Therefore, we hypothesize that, in accordance with the regression of Meckel's cartilage, the rapidly growing temporomandibular joint provided mechanical stress that accelerated the growth and descent of the inferior process of the tegmen tympani via the discomalleolar ligament. The usual diagram showing bony fissures around the tegmen tympani may overestimate the role of the tympanic bone in the fetal middle-ear closure.Journal of Anatomy 06/2011; 218(6):690-8. · 2.37 Impact Factor -
Article: Immunohistochemical distribution of desmin in the human fetal heart.
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ABSTRACT: Desmin is a member of the intermediate filaments, which play crucial roles in the maturation, maintenance and recovery of muscle fibers. Its expression has been examined in human cardiac muscle, rat and chicken, but its spatial distribution in the human fetal heart has not been described. The present study investigated desmin expression in the human fetal heart and associated great vessels in 14 mid-term fetuses from 9 to 18 weeks of gestation. Immunoreactivity for myosin heavy chain (MHC) and alpha smooth muscle actin (α-SMA), as well as neuron-specific enolase (NSE), was also examined. Increased expression of desmin from 9 to 18 weeks was clearly localized in the atrial wall, the proximal portions of the pulmonary vein and vena cava, and around the atrioventricular node. Desmin-positive structures were also positive for MHC. Meanwhile, the great vessels were also positive for α-SMA. The distribution of desmin exhibited a pattern quite different from that described in previous studies of rat and chicken. Thus, desmin in the human fetal heart does not seem to play a general role in myocardial differentiation but rather a specific role closely related to the maturation of the α-isozyme of MHC. Desmin expression in the developing fetal heart also appeared to be induced by mechanical stress due to the involvement of venous walls against the atrium.Journal of Anatomy 04/2011; 219(2):253-8. · 2.37 Impact Factor -
Article: Pleuroperitoneal canal closure and the fetal adrenal gland.
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ABSTRACT: Pleuroperitoneal canal (PP canal) closure is generally considered to result from an increase in the height, and subsequent fusion, of the bilateral pleuroperitoneal folds (PP folds). However, the folds develop in the area ventral to the adrenal, in contrast to the final position of the diaphragm, which extends to the dorsal side of the adrenal (the "retro-adrenal" diaphragm). We examined the semiserial histology of 20 human embryos and fetuses (crown-rump length 11-40 mm). We started observations of the canal at the stage through which the lung bud extends far caudally along the dorsal body wall to the level of the future adrenal, and the phrenic nerve has already reached the PP fold. Subsequently, the developing adrenal causes narrowing of the dorsocaudal parts of the canal, and provides the bilateral midsagittal recesses or "false" bottoms of the pleural cavity. However, at this stage, the PP fold mesenchymal cells are still restricted to the ventral side of the adrenal, especially along the liver and esophagus. Thereafter, in accordance with ascent of the lung, possibly due to anchoring of the liver to the adrenal, the PP fold mesenchymal cells seem to migrate laterally along the coelomic mesothelium covering some sheet-like loose mesenchymal tissue behind the adrenal. Final closure of the PP canal by lateral migration to provide the "retro-adrenal" diaphragm is a process quite different from the common dogma. It is likely that the sheet-like loose mesenchymal tissue becomes the caudal part of the pleural cavity through a process involving cell death.The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 03/2011; 294(4):633-44. · 1.47 Impact Factor -
Article: Venous drainage from the developing human base of mandible including Meckel's cartilage: the so-called Serres' vein revisited.
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ABSTRACT: The present study describes the venous drainage, especially, that via the so-called Serres' vein, from border areas between two different types of ossifications: the endochondral ossification of Meckel's cartilage in close topographical relation with the membranous ossification of the mandible. Frontal and transverse sections of 25 human fetuses between 8 and 16 weeks of post-conception development. All sections were stained with hematoxylin, and eosin and azan. At 9 weeks, a distinct vein (Serres' vein) is seen originating from the endochondral ossification of Meckel's cartilage. At 11 weeks, the vein collects blood sinusoids from both the endochondral and membranous ossification areas. At 12 weeks the vein accompanies a definite bony canal, the Serres' canal. The vein does not extend anteriorly beyond a level of the deciduous canine germ that was located anterior to the mental foramen. Notably, up to 12 weeks, the vein becomes clearly isolated from the inferior alveolar nerve, artery, and vein. Serres' vein seems to be a unique drainage route of ossification, not of the tooth germ, and is similar to veins at the usual diaphysis of a long bone. Although the Serres' canal had been termed "canal of the deciduous dentition", there appears to be no topographical relation with deciduous germs.Anatomia Clinica 02/2011; 33(7):575-81. · 0.93 Impact Factor -
Article: [Morphodifferentiation of the stapedius muscle. Personal contribution].
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ABSTRACT: The aim of this study is to explain the origin of the anomalies and variations that affect the muscle-tendon complex of the stapes. These are interpreted from the model of the stapes muscle differentiation formed by two independent anlagen (Rodríguez-Vázquez, 2005, 2009 and Rodríguez-Vázquez et al., 2010): one for the belly muscle, located on the second branchial arch medially to the facial nerve; and another for the tendon, formed from the internal segment of interhiale. The external segment of the interhiale usually disappears. The pyramidal eminence is organized from the mesenchymal condensation sorrounding the muscle belly, which is independent of the second branchial arch cartilage.Anales de la Real Academia Nacional de Medicina 01/2010; 127(1):153-63; discussion 164-9. -
Article: [The cartilaginous differentiation of the second arch in the human. From the traditional to the actual theory. Personal contribution].
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ABSTRACT: Classically, the cartilaginous formation of the second pharyngeal arch has been described as a continuous structure wich will be the primary skeleton of the arch. Actually this theory has experimented a deep change Rodríguez Vázquez, 2005, and Rodríguez Vázquez et al. 2006, have a new cartilaginous differentiation model in the second pharyngeal arch and thus of its derivates in the human craniofacial development. The stapes and Reichert's cartilage have been formed by independent anlages. The cartilaginous differentiation model of the second arch, has allowed us to know and interpret the variations and classify them.Anales de la Real Academia Nacional de Medicina 02/2007; 124(4):667-78; discussion 678-9. -
Article: [New contributions to development of the cartilage of the second branchial arch and its clinical incidence].
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ABSTRACT: In the human embryo, the second branchial arch has a cartilaginous structure called Reichert's cartilage named alter its discoverer who first classified the visceral arches in 1837. The concept of Reichert's cartilage is still interpreted today as a structure that gives rise to the stapes of the middle ear, to the styloid process, to the styloid ligament, the lesser horns and the superior part of the hyoid body. The normal pattern of the cartilage of the second branchial arch has been studied in human fetuses, giving rise to a new interpretation. It has been classified into two parts, one longer cranial one joined to the otic capsule and another smaller caudal one associated with the hyoid bone. In our opinion, variability in the shape and the arrangement of the cranial portion will condition the formation of a styloid process of different length and morphology. Our studies of this cartilage explain the mechanism by which certain craniofacial variations with clinical implications can arise.Anales de la Real Academia Nacional de Medicina 02/2004; 121(3):441-7; discussion 448-50. -
Article: La diferenciación cartilaginosa del segundo arco en el hombre. De la teoría tradicional a la actual. Aportación personal
Anales de la Real Academia Nacional de Medicina, ISSN 0034-0634, Nº 4, 2007, pags. 667-682.
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Institutions
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2011–2012
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Complutense University of Madrid
- Departamento de Anatomía y Embriología Humana II
Madrid, Madrid, Spain
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