Josephine Pressacco

Publications (12)43.47 Total impact

• Article: Hybrid Treatment of a Complex Aortic Arch Aneurysm with an Aberrant Left Vertebral Artery.

  Emmanuel Moss, Feras Khaliel, Josephine Pressacco, Philippe Demers, Raymond Cartier
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  ABSTRACT: We report a case of an elderly male with significant comorbidities and a dominant aberrant left vertebral artery originating on an aneurysmal aortic arch. The patient underwent a successful staged hybrid procedure with aortic arch debranching and left vertebral artery transposition onto the left common carotid artery, followed by endovascular aneurysmal repair.
  Journal of Cardiac Surgery 01/2013; · 0.87 Impact Factor
• Article: Cardiac masses: an integrative approach using echocardiography and other imaging modalities.

  Dominique Auger, Josephine Pressacco, François Marcotte, Annie Tremblay, Annie Dore, Anique Ducharme
  Heart (British Cardiac Society) 07/2011; 97(13):1101-9. · 4.22 Impact Factor
• Article: Imaging biomarkers in atherosclerosis trials.

  Jean-Claude Tardif, Frédéric Lesage, François Harel, Philippe Romeo, Josephine Pressacco
  Circulation Cardiovascular Imaging 05/2011; 4(3):319-33. · 5.94 Impact Factor
• Article: Gadofosveset-enhanced 4D magnetic resonance angiography as a means of localizing the site of post aortic graft leak.

  Alexandre Semionov, Josephine Pressacco
  Magnetic Resonance Imaging 02/2011; 29(2):300-2. · 1.99 Impact Factor
• Article: Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome.

  Jean-Claude Tardif, Philippe L L'allier, Reda Ibrahim, Jean C Grégoire, Anna Nozza, Mariève Cossette, Simon Kouz, Marc-André Lavoie, Janie Paquin, Tilmann M Brotz, Rebecca Taub, Josephine Pressacco
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  ABSTRACT: Production of leukotrienes by 5-lipoxygenase (5-LO) has been linked to unstable atherosclerotic plaques and cardiovascular events. VIA-2291 is a potent 5-LO inhibitor. In a double-blinded study, 191 patients were randomly assigned 3 weeks after an acute coronary syndrome to receive 25, 50, or 100 mg VIA-2291 or placebo daily for 12 weeks. The primary study end point, whole blood stimulated leukotriene LTB4 at trough drug level, was reduced in all VIA-2291 groups (P<0.0001) in a dose-dependent fashion, with approximately 80% inhibition in >90% of patients in the 100-mg group. A significant reduction of urine leukotriene LTE4 was obtained in all dose groups. No serious adverse events were considered related to study drug. A subset of 93 patients who had undergone a 64-slice coronary CT examination at baseline continued on study medication for a total of 24 weeks and underwent a repeat scan. Five of these patients withdrew or were noncompliant and 28 had nonevaluable scans. Among the 60 remaining patients, new coronary plaques were observed in 5 of 18 (27.8%) placebo-treated patients and in 2 of 42 (4.8%) VIA-2291-treated patients (P=0.01). A reduction in noncalcified plaque volume at 24 weeks versus placebo was observed in VIA-2291-treated groups in the 34 of these 60 patients in whom this end point was analyzable (P<0.01). VIA-2291 reduces leukotriene production at 12 weeks after an acute coronary syndrome. Preliminary data from the CT substudy suggest that such a reduction in leukotriene production may influence atherosclerosis; however, this requires confirmation in a larger study. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00358826.
  Circulation Cardiovascular Imaging 02/2010; 3(3):298-307. · 5.94 Impact Factor
• Article: Evaluation of adult congenital heart disease by cardiac magnetic resonance imaging.

  François Marcotte, Nancy Poirier, Josephine Pressacco, Eléonore Paquet, Lise-Andrée Mercier, Annie Dore, Reda Ibrahim, Paul Khairy
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  ABSTRACT: Cardiovascular magnetic resonance (CMR) imaging plays an essential role in the evaluation and follow-up of adult congenital heart disease (ACHD), providing safe, high-resolution imaging of some of the most complex anatomies encountered. Unlimited by acoustic windows and capable of tissue characterization, CMR is devoid of ionizing radiation and provides superior three-dimensional spatial resolution to transthoracic echocardiography and superior temporal resolution to computed tomography, making it the gold standard for various cardiac and great vessel imaging indications in ACHD. In this state-of-the art review, we provide an overview of CMR examination methods and detail the various approaches and classical findings in the more common forms of ACHD. Although this review touches upon technical aspects of CMR imaging in ACHD, it is primarily geared toward the adult congenital caregiver (i.e., clinical, interventional, or surgical), highlighting relevant practical considerations. To enhance the clinical utility of this review, numerous examples with intraoperative correlates are provided to highlight our imaging approaches for various defects. As CMR image acquisition may be time consuming and requires patient collaboration (e.g., intermittent breath holding), a systemic approach is required to maximize efficiency. A thorough knowledge of ACHD anatomy and natural history is essential in maximizing image interpretation. Proficient scanning is further enabled by clearly outlined study objectives with prior documentation of interventional and surgical procedures, where applicable.
  Congenital Heart Disease 08/2009; 4(4):216-30. · 0.90 Impact Factor
• Article: Imaging features of constrictive pericarditis: beyond pericardial thickening.

  Giuseppe Napolitano, Josephine Pressacco, Eleonore Paquet
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  ABSTRACT: Constrictive pericarditis is caused by adhesions between the visceral and parietal layers of the pericardium and progressive pericardial fibrosis that restricts diastolic filling of the heart. Later on, the thickened pericardium may calcify. Despite a better understanding of the pathophysiologic basis of the imaging findings in constrictive pericarditis and the recent advent of magnetic resonance imaging (MRI) technology, which has dramatically improved the visualization of the pericardium, the diagnosis of constrictive pericarditis remains a challenge in many cases. In patients with clinical suspicion of underlying constrictive pericarditis, the most important radiologic diagnostic feature is abnormal pericardial thickening, which can be shown readily by computed tomography (CT) and especially by MRI, and is highly suggestive of constrictive pericarditis. Nevertheless, a thickened pericardium does not always indicate constrictive pericarditis. Furthermore, constrictive pericarditis can occur without pericardial thickening.
  Canadian Association of Radiologists Journal 03/2009; 60(1):40-6. · 0.69 Impact Factor
• Article: Images in cardiovascular medicine. Incomplete longitudinal ventricular septal fracture after blunt chest trauma.

  François Marcotte, Jean-Pierre Lavoie, Annie Dore, Paul Khairy, Lise-Andrée Mercier, Eléonore Paquet, Nancy Poirier, Josephine Pressacco
  Circulation 01/2009; 118(25):e836-7. · 14.74 Impact Factor
• Article: MR angiography of renal-hepatic arteriovenous malformation.

  Josephine Pressacco, Gilles Hudon, Jean-Francois Tanguay, Patricia Ugolini
  American Journal of Roentgenology 09/2007; 189(2):W111-2. · 2.78 Impact Factor
• Article: Answer to case of the month #106. Pelvic Digit.

  Mary C Casey, Jean-Pierre Phancao, Josephine Pressacco
  Canadian Association of Radiologists Journal 03/2006; 57(1):51-3. · 0.69 Impact Factor
• Article: Concordance between an electroanatomic mapping system and cardiac MRI in arrhythmogenic right ventricular cardiomyopathy.

  Jean-François Roux, Marc Dubuc, Josephine Pressacco, Denis Roy, Bernard Thibault, Mario Talajic, Peter G Guerra, Laurent Macle, Paul Khairy
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  ABSTRACT: A 29-year-old man presenting with syncopal ventricular tachycardia was diagnosed with arrhythmogenic right ventricular (RV) cardiomyopathy. Cardiac magnetic resonance imaging (MRI) revealed an unequivocal dyskinetic segment at the basal portion of the RV lateral free wall. Three-dimensional electroanatomic voltage mapping using the EnSite NavX system recorded a low voltage area corresponding to the diseased portion of the right ventricle identified by MRI. This report describes concordance between cardiac MRI and this novel mapping system in arrhythmogenic RV cardiomyopathy.
  Pacing and Clinical Electrophysiology 02/2006; 29(1):109-12. · 1.35 Impact Factor
• Article: Extensive radiation-induced heart disease in an adult patient treated for lymphoma as a child.

  Frédéric Poulin, Alexandre Semionov, Philippe Roméo, Philippe Demers, Josephine Pressacco, Arsène Basmadjian
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  ABSTRACT: Cardiovascular complications are the second leading cause of late mortality in survivors of Hodgkin's lymphoma (HL) exposed to mediastinal radiotherapy. Symptomatic cardiac disease following classic thoracic irradiation for HL is reported in 10%-30% of patients at 5-10 years of follow-up. We present the case of a 44-year-old man with a history of left cervical nodular lymphocyte predominant HL treated at childhood with 40 Gy extended field thoracic irradiation (Mantle) who presented with mixed aortic and mitral valve disease, coronary artery stenosis, myocardial and aortic calcifications, and mediastinal fibrosis. Despite extensive cardiac surgery, the postoperative course was complicated and resulted in the patient's death. We review herein the typical cardiac involvement related to mediastinal radiotherapy and the controversies surrounding its surgical approach.
  The Canadian journal of cardiology 27(3):390.e1-4. · 3.36 Impact Factor