Jong Won Park

Yeungnam University, 경산시, Gyeongsangbuk-do, South Korea

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Publications (98)176.53 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. Materials and methods: Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded from this study if they were younger than 19 years old, or had urine albumin/creatinine ratio (UACR) ≥ 30 mg/g or diabetes mellitus. There were 10 608 participants included in this study. The participants were divided into three groups according to their UACR tertiles. Results: There were 1560; 1561; and 1552 male and 1982; 1975; and 1978, female participants in the low, middle, and high tertile groups, respectively. The results indicated the association between low-grade albuminuria and the numbers of metabolic syndrome (MetS) components or Framingham risk score, and the presence of MetS or the proportions of participants at high cardiovascular risk. Univariate and multivariate linear regression analyses demonstrated an association between the UACR and average hearing threshold (AHT) that was observed in both sexes. Multivariate analyses showed that mean AHTs in the low, middle, and high tertile groups were, respectively, 16.127 dB, 17.139 dB, and 18.604 dB for men, and 14.842 dB, 15.100 dB, and 16.353 dB, respectively, for women. Low-frequency, mid-frequency, and high-frequency hearing thresholds according to UACR tertiles showed similar trends. In both sexes, multivariate logistic regression analyses revealed that participants in the low and middle tertile groups had a decreased risk for hearing loss compared to participants in the high tertile group. Conclusion: Low-grade albuminuria was associated with hearing impairment in the non-diabetic participants of this study. Key messages Low-grade albuminuria is associated with MetS and cardiovascular risk in the non-diabetic population. Low-grade albuminuria is associated with hearing thresholds and hearing loss in the non-diabetic population. Participants with low-grade albuminuria may be closely monitored for hearing impairment.
    Annals of Medicine 11/2015; DOI:10.3109/07853890.2015.1093163 · 3.89 Impact Factor
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    ABSTRACT: Advances in bioimpedance analysis (BIA) technologies now enable visceral fat area (VFA) to be assessed using this method. The aim of this study was to evaluate the clinical relevance and usefulness of VFA as a predictor of chronic kidney disease (CKD) and metabolic syndrome (MS), using BIA. We identified 24,791 adults who underwent voluntary routine health checkups at Yeungnam University Hospital. In total 22,480 patients were recruited into our study. Participants were divided into 3 tertiles based on their VFA: low, middle, and high tertiles. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m(2). The higher tertile of VFA was associated with a higher prevalence of diabetes mellitus, hypertension, and male sex. Waist-to-hip ratio, body mass index, blood pressure, lean mass, body fat %, and fasting glucose, total cholesterol, triglyceride, GGT, AST, ALT, and uric acid levels all increased as the VFA tertile increased (P < 0.001 for all variables). The prevalence of CKD was 6.9% in the low tertile, 13.9% in the middle tertile, and 25.2% in the high tertile (P < 0.001). The prevalence of MS was 2.2% in the low tertile, 12.8% in the middle tertile, and 36.7% in the high tertile (P < 0.001). The AUROC values for VFA were higher than those for BMI and WHR. For VFA, the sensitivity and specificity for predicting CKD were 62.66% (95% CI, 61.0-64.3) and 64.22% (95% CI, 63.5-64.9), respectively, and 77.65% (95% CI, 76.3-79.0), and 68.81% (95% CI, 68.1-69.5), respectively for predicting MS. Our results demonstrated that the VFA, measured by BIA, is a simple method for predicting the risk of CKD and MS. © 2015 S. Karger AG, Basel.
    Kidney and Blood Pressure Research 04/2015; 40(3):223-230. DOI:10.1159/000368498 · 2.12 Impact Factor
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    Ki-Sung Son · Hyeong-Seop Jeon · Jin-Ho Park · Jong Won Park ·
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    ABSTRACT: Acceleration sensors are usually used to measure the vibration of a structure. Although this is the most accurate method, it cannot be used remotely because these are contact-type sensors. This makes measurement difficult in areas that cannot be easily approached by surveyors, such as structures located in high or dangerous areas. Therefore, a method that can measure the vibration without installing sensors is required for the vibration measurement of structures located in these areas. Many conventional studies have been carried out on non-contact-type vibration measurement methods using cameras. However, they have been applied to structures with relatively large vibration displacements such as buildings or bridges, and since most of them use targets, people still have to approach the structure to install the targets. Therefore, a new method is required to supplement the weaknesses of the conventional methods. In this paper, a method is proposed to measure vibration displacements remotely using a camera without having to approach the structure. Furthermore, an estimation method for the measurement resolution and measurement error is proposed for the vibration displacement of a cylindrical structure measured using the proposed measurement method. The proposed methods are described, along with experimental results that verified their accuracy.
    Nuclear Engineering and Technology 03/2015; 15(4). DOI:10.1016/ · 0.77 Impact Factor
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    ABSTRACT: Background: The aim of this study was to determine whether metabolic syndrome (MetS) or chronic kidney disease (CKD) is associated with hearing thresholds in the general Korean population. Patients and methods: A total of 16,554 participants were included in this study. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III guidelines, and CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or a dipstick proteinuria result of ≥1+. The hearing thresholds were measured at 0.5, 1, 2, 3, 4, and 6 kHz. Low-frequency (Freq) was defined as pure-tone averages at 0.5 and 1 kHz, while Mid-Freq and High-Freq were defined as the average thresholds at mid-frequency (2 and 3 kHz) and high frequency (4 and 6 kHz), respectively. Results: In men, the hearing thresholds were 15.1 ± 14.5 dB, 22.2 ± 21.3 dB, and 37.3 ± 26.5 dB for Low-, Mid-, and High-Freq, respectively. In women, the hearing thresholds were 14.9 ± 15.3 dB, 16.6 ± 18.0 dB, and 26.1 ± 21.5 dB for Low-, Mid-, and High-Freq, respectively. The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories. Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders. In the multivariate analysis, MetS was associated with increased hearing thresholds in women, and CKD was associated with increased hearing thresholds in men and women. Conclusion: MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women. Therefore, patients with MetS or CKD should be closely monitored for hearing impairment.
    PLoS ONE 03/2015; 10(3):e0120372. DOI:10.1371/journal.pone.0120372 · 3.23 Impact Factor

  • International journal of medical sciences 01/2015; 12(12):946-951. DOI:10.7150/ijms.13184 · 2.00 Impact Factor
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    ABSTRACT: The presence of peritoneal dialysate when performing bioimpedance analysis may affect body composition measurements. The aim of this study was to evaluate the impact of dialysate on body composition measurements in Asians. Forty-one patients undergoing maintenance peritoneal dialysis in our hospital peritoneal dialysis unit were included in this study. Dialysate was drained from the abdomen prior to measurement, and bioimpedance analysis was performed using multi-frequency bioimpedance analysis, with each subject in a standing position (D-). Dialysate was then administered and the measurement was repeated (D+). The presence of peritoneal dialysate led to an increase in intracellular water (ICW), extracellular water (ECW), and total body water (D-: 20.33 ± 3.72 L for ICW and 13.53 ± 2.54 L for ECW; D+: 20.96 ± 3.78 L for ICW and 14.10 ± 2.59 L for ECW; P < 0.001 for both variables). Total and trunk oedema indices were higher in the presence of peritoneal dialysate. In addition, the presence of peritoneal dialysate led to an overestimation of mineral content and free fat mass (FFM) for the total body; but led to an underestimation of body fat (D-: 45.80 ± 8.26 kg for FFM and 19.30 ± 6.27 kg for body fat; D+: 47.51 ± 8.38 kg for FFM and 17.59 ± 6.47 kg for body fat; P < 0.001 for both variables). Our results demonstrate that the presence of peritoneal dialysate leads to an overestimation of FFM and an underestimation of fat mass. An empty abdomen is recommended when evaluating body composition using bioimpedance analysis.
    Nephrology 11/2014; 19(11). DOI:10.1111/nep.12322 · 2.08 Impact Factor
  • Jong Won Park · Kyoung-Jin Min · Dong Eun Kim · Taeg Kyu Kwon ·
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    ABSTRACT: Withaferin A is a steroidal lactone purified from the Indian medicinal plant, Withania somnifera. Withaferin A has been shown to inhibit the proliferation, metastasis, invasion and angiogenesis of cancer cells. In the present study, we investigated whether withaferin A induces apoptosis in the human head and neck cancer cells, AMC-HN4. Withaferin A markedly increased the sub-G1 cell population and the cleavage of poly(ADP-ribose) polymerase (PARP), which are markers of apoptosis. Pan-caspase inhibitor, z-VAD-fmk (z-VAD), markedly inhibited the withaferin A-induced apoptosis. However, the withaferin A-induced increase in the expression of COX-2 was not affected by treatment with z-VAD. Furthermore, withaferin A upregulated cyclooxygenase-2 (COX-2) expression. The COX-2 inhibitor, NS-398, reduced the withaferin A-induced production of prostaglandin E2. However, treatment with NS-398 did not affect the sub-G1 population and the cleavage of PARP. In addition, the withaferin A-induced apoptosis was independent of reactive oxygen species production. Thiol donors [N-acetylcysteine (NAC) and dithiothreitol (DTT)] reversed withaferin A-induced apoptosis. Therefore, our data suggest that withaferin A induces apoptosis through the mechanism of thiol oxidation in head and neck carcinoma cells.
    International Journal of Molecular Medicine 10/2014; 35(1). DOI:10.3892/ijmm.2014.1983 · 2.09 Impact Factor
  • Young-Chul Choi · Hyeong-Seop Jeon · Ki-Sung Son · Jong Won Park ·

    10/2014; 24(10):795-801. DOI:10.5050/KSNVE.2014.24.10.795
  • Ki-Sung Son · Hyeong-Seop Jeon · Soon Woo Han · Jong Won Park ·

    09/2014; 24(9):716-723. DOI:10.5050/KSNVE.2014.24.9.716
  • Steven J. Jordan · Woo‐Baik Lee · Jong Won Park ·
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    ABSTRACT: Program trading has been identified as a mechanism that links the futures and spot markets. It has also been identified as a potential cause of market instability leading to regulations on program trading during volatile markets. Program trading halts provide a natural experiment to test the hypothesis that program trading is an important mechanism that maintains relative market pricing. This study is the first to analyze the effect of removing all program trades on the connectedness of the spot and futures markets during large market moves. The Korean regulatory environment has several unique properties that lend itself to such a study. Overall, we provide evidence that (i) the basis is unaffected when program trading is eliminated during large market moves, (ii) arbitrage exists and appears to be able to identify uninformed price moves, (iii) the data do not support the argument that halts provide a time-out period in order for markets to reevaluate information, and (iv) there are costs associated with imposing trading halt regulations on financial markets. © 2014 Wiley Periodicals, Inc. Jrl Fut Mark
    Journal of Futures Markets 08/2014; DOI:10.1002/fut.21690 · 0.46 Impact Factor
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    ABSTRACT: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whole blood (reference, 4.07 to 5.17 mg/dL). The level of ionized calcium in serum was higher than that in whole blood (p < 0.001). Bland-Altman analysis showed that difference for ionized calcium was 0.5027. For the difference, the nonstandardized β was -0.4389 (p < 0.001) and the intercept was 2.2418 (p < 0.001). There was a significant difference in the distribution of categories of ionized calcium level between two methods (κ, 0.279; p < 0.001). This study demonstrates that whole blood ionized calcium is underestimated compared with serum ionized calcium. Positive difference increases as whole blood ionized calcium decreases. Therefore, significant hypocalcemia in whole blood ionized calcium should be verified by serum ionized calcium.
    The Korean Journal of Internal Medicine 03/2014; 29(2):226-30. DOI:10.3904/kjim.2014.29.2.226 · 1.43 Impact Factor
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    Ki-Sung Son · Hyeong-Seop Jeon · Jin-Ho Park · Jong Won Park ·
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    ABSTRACT: Vibration measurement of rotating shafts by installing sensors such as accelerometers or displacement sensors is costly and dangerous in some cases. As an alternative method, vibration measurement using camera images has been researched because sensor installation is not needed and displacement of a rotating shaft can be directly evaluated. This paper also suggests the enhanced technique applicable to the measurement of vibration of a large-scale rotating shaft. The concurrent methods based on camera images use marks, which are hardly applicable to rotating shafts. The proposed method measures vibration without any marks by evaluating shape errors. The working principle of the method is described and verified by a series of experiments.
    02/2014; 24(2). DOI:10.5050/KSNVE.2013.24.2.131
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    ABSTRACT: Background: The purpose of the present study was to examine the effectiveness of paricalcitol for the prevention of epithelial-to-mesenchymal transition (EMT). Materials and methods: Human peritoneal mesothelial cells (HPMCs) were cultured in media containing transforming growth factor β1 (TGF-β1) with or without paricalcitol. Forty-two male Sprague-Dawley rats were divided into three groups. In the control group, the catheter was inserted but no dialysate was infused. The peritoneal dialysis (PD) group was infused with a conventional 4.25% dialysis solution. The paricalcitol group was infused with 4.25% dialysis solution and cotreated with paricalcitol. Results: Exposure of HPMCs to TGF-β1 decreased the protein level of the epithelial cell marker and increased the expression levels of the mesenchymal markers. Cotreatment with paricalcitol increased the protein levels of the epithelial cell marker and decreased those of mesenchymal markers compared with their levels in cells treated with TGF-β1 alone. Exposure of HPMCs to TGF-β1 significantly increased the phosphorylation of Smad2 and Smad3. Cotreatment with paricalcitol significantly decreased the phosphorylation of Smad2 and Smad3 compared with that of cells treated with TGF-β1 alone. After 8 weeks of experimental PD in rats, the thickness of the peritoneal membrane in the PD group was significantly increased compared with that of the control group. Cotreatment with paricalcitol decreased peritoneal thickness. Conclusion: The present study showed that paricalcitol attenuates the TGF-β1-induced EMT in peritoneal mesothelial cells. We suggest that paricalcitol may preserve peritoneal mesothelial cells during PD and could thus be of value for the success of long-term PD.
    Nephron Experimental Nephrology 01/2014; 126(1):1-7. DOI:10.1159/000357156 · 2.56 Impact Factor
  • Jong Won Park · Seok Hui Kang · Jun Young Do ·
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    ABSTRACT: Introduction: Changes in peritoneal membrane characteristics including epithelial-mesenchymal transition are an important problem in the maintenance of peritoneal dialysis (PD). This study reports a 3-year follow-up assessment of the effects of low-glucose degradation products (GDP) solution, including epithelial-mesenchymal transition. Materials and methods: Adult patients who received continuous ambulatory PD between April 2001 and March 2007 were identified, and those who maintained on PD with the same solution for more than 3 years were included. Patients with an initial effluent score of 3 (fibroblastoid cells dominant in overnight effluent dialysate) were excluded. The patients were divided into two groups according to the dialysate: standard and low-GDP. The following were measured: cancer antigen-125, cell score, normalized protein equivalent of nitrogen appearance, dialysate-plasma creatinine and sodium ratios, and residual renal function. Cell score and peritoneal equilibration test were measured at 1, 6, 12, 18, and 24 months after the initiation of PD. Results: Fifty patients were in the standard group and 76 in the low-GDP group. No significant difference in dialysate-plasma creatinine ratio was detected at baseline and at the end-point of follow-up between the two groups. Dialysate-plasma sodium ratio decreased significantly at the end-point of follow-up in the low-GDP group. Initial and follow-up cancer antigen-125 levels were higher in the low-GDP group. Multivariable analysis showed that low-GDP was associated with a higher cell score 3-free survival rate. Conclusions: The present study shows that a low-GDP solution may be associated with preserving the mesothelial cell and peritoneal membrane characteristics.
    Iranian journal of kidney diseases 01/2014; 8(1):58-64. · 0.92 Impact Factor
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    ABSTRACT: The recipient candidate was a 51-year-old male with end-stage renal disease owing to diabetes mellitus. The initial immunosuppressive regimen included basiliximab for induction and tacrolimus, mycophenolate mofetil, and steroids. Urine output was 413 mL/day on the operative day and 100 mL/day on the postoperative day (POD) 1. There was no definite stenosis of the ureter or vessels. He had anuria on POD 2~4 and he had undergone hemodialysis. His serum creatinine level did not decrease. Therefore, a graft biopsy was performed on POD 4. The pathologic finding was consistent with acute calcineurin inhibitor (CNI) toxicity. There was no evidence of rejection or acute tubular necrosis. Anuria continued on POD 6; therefore, we started sirolimus instead of a CNI based regimen. Graft function was gradually recovered 1 day after reduction of CNI dose and hemodialysis was stopped. The serum creatinine level was normalized on POD 10. He was discharged on POD 21.
    01/2014; 28(3):165. DOI:10.4285/jkstn.2014.28.3.165
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    ABSTRACT: The seven mitochondrial DNA regions (ND2, ND5, ND4, ND4L, ND6, ND1 and 12SrRNA) of Haliotis discus hannai were examined to estimate the availability as a genetic marker for the study of population genetic. The region with the highest genetic variation was ND4 (Haplotype diversity = 1.0000, Nucleotide diversity = 0.0108). On the other hand, ND2 and ND1 regions have significantly appeared genetic divergence between clusters (divergence of 90% and 87%). Also, pairwise between clusters within ND2 and ND1 regions showed high values; 0.4061 (P = 0.0000), 0.4805 (P = 0.0000) respectively. Therefore we can infer that it is the most efficient and accurate way to analyze the region of ND4 with the highest variation in addition to the regions of ND2 and ND1, which formed clusters with high bootstrap value, for study of population genetic structure in this species.
    12/2013; 29(4). DOI:10.9710/kjm.2013.29.4.335
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    ABSTRACT: The effect of three different diets (formulated diet, FD; Undaria pinnatifida, UP; Laminaria japonica, LJ) on growth in the Haliotis discus hannai for 90 days was investigated. The shell length of UP ( mm) and LJ ( mm) were significantly faster than those of FD ( mm) (P < 0.05). However, shell breadth and total weight were no significant difference among three diets. On the other hand, the weight gain of FD (16.65% for 0-45day and 25.71% for 45-90day) tend to have higher than those of UP (14.57% and 23.30%) and LJ (12.65% and 24.51%). This results shows that seaweed diets (UP and LJ) help the shell growth of abalone and formulated diet (FD) help the weight gain of abalone. Therefore, the growth of shell and muscle will depend on different diets.
    09/2013; 29(3). DOI:10.9710/kjm.2013.29.3.233
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    Ki-Sung Son · Hyeong-Seop Jeon · Jin-Ho Park · Jong Won Park ·
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    ABSTRACT: Vibration measurements using image processing have been studied by many researchers as it can remotely measure vibration displacements at multiple points simultaneously. It is difficult, however, to obtain accurate displacement from the measured image signals because the resolution of image data is dependent on camera performance and normally lower than that of vibration transducer directly measured. This paper suggests the enhanced technique for vibration displacement measurement by applying the expected value of edge probability distribution to the varying pixel points in the image. The method can both increase the resolution limit of camera image and decrease the measurement errors. The working performance of the proposed technique is verified applying to the vibration measurement of a rotating machine.
    09/2013; 23(9). DOI:10.5050/KSNVE.2013.23.9.789
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    ABSTRACT: Background: The aim of this study was to evaluate regression equations correcting estimated glomerular filtration rate (eGFR) and the clinical significance of the corrected eGFRs calculated using these equations. Patients and methods: The authors determined how well corrected eGFR values calculated using regression equations predict residual renal function (RRF). Results: RRF values were correlated with all eGFR values of nonanuric patients of both genders. Peritoneal creatinine clearance values were not correlated with eGFRs in anuric patients of either gender. In males, eGFR biases ranged from -5.66 to -3.25, and in females, from -5.96 to -3.21. However, these biases decreased when eGFR values were transformed to corrected eGFR values. The area under the curve of the corrected eGFR values was acceptable for a diagnosis of RRF loss. Conclusion: Corrected eGFR values obtained using these methods may provide an alternative means of predicting RRF without 24-hour urine collection.
    Nephron Clinical Practice 09/2013; 123(3-4):229-237. DOI:10.1159/000353221 · 1.40 Impact Factor
  • Jong Seon Park · Jea Hee Kim · Kyung-Sik Ko · Jong Won Park ·

    08/2013; 16(8):914-926. DOI:10.9717/kmms.2013.16.8.914

Publication Stats

751 Citations
176.53 Total Impact Points


  • 2011-2015
    • Yeungnam University
      • Division of Internal Medicine
      경산시, Gyeongsangbuk-do, South Korea
  • 2005-2015
    • Chungnam National University
      • Department of Information and Communication Engineering
      Daiden, Daejeon, South Korea
  • 2014
    • Keimyung University
      • Department of Microbiology
      Sŏul, Seoul, South Korea
  • 2009-2014
    • University of Seoul
      • • College of Business Administration
      • • Department of Business Administration
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • Korea Institute of Science and Technology
      • Clean Energy Research Center
      Sŏul, Seoul, South Korea
  • 2010-2012
    • National Fisheries Research and Development Institution
      Sŏul, Seoul, South Korea
    • Good Samsun Hospital
      Tsau-liang-hai, Busan, South Korea
    • Loughborough University
      Loughborough, England, United Kingdom
  • 2008-2012
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Shinshū, South Gyeongsang, South Korea
  • 2010-2011
    • Hallym University Medical Center
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 1995-2011
    • Catholic University of Korea
      • • Department of Internal Medicine
      • • Department of Dermatology
      Seoul, Seoul, South Korea
  • 2007
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • Seoul Veterans Hospital
      Sŏul, Seoul, South Korea
  • 2004
    • Cheju Halla University
      Tse-tsiu, Jeju, South Korea
  • 2000
    • Inha University
      • Department of Electronic and Electrical Engineering
      Chemulpo, Incheon, South Korea
  • 1996
    • Semyung University
      Seishō-gun, North Gyeongsang, South Korea