Jian Liu

Lanzhou University, Kao-lan-hsien, Gansu Sheng, China

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Publications (46)174.8 Total impact

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    ABSTRACT: We have developed an efficient strategy for synthesizing a strongly coupled Au/Fe3O4/GO hybrid material to improve the catalytic activity, stability, and separation capability of Au nanoparticles (NPs) and Hg(2+). The hybrid material can be synthesized by the direct anchoring of Au and Fe3O4 NPs on the functional groups of GO. This approach affords strong chemical attachments between the NPs and GO, allowing this hybrid material to ultrasensitively detect Hg(2+) in aqueous solutions with a detection limit as low as 0.15 nM. In addition, the deposition of Hg(0) on the surface of Au/Fe3O4/GO could be quickly (within 30 min) and efficiently (>99% elimination efficiency) removed by the simple application of an external magnetic field and then Au/Fe3O4/GO could be subsequently reused at least 15 times, with the elimination efficiency remaining high (>96%).
    Nanoscale 04/2015; DOI:10.1039/c5nr00527b · 6.74 Impact Factor
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    ABSTRACT: The application of nanohybrids in water treatment by the catalytic degradation of various pollutants has attracted much attention from researchers. Here, the Pd/Fe3O4-PEI-RGO nanohybrids (1d) with high shape selectivity and high specific surface area have been synthesized by dispersion of Pd NPs and Fe3O4 NPs on PEI modified graphene oxide sheets. This nanohybrids show superior catalytic activity toward methylene blue with a high degradation efficiency above 99 % in the presence of NaBH4 in aqueous solution, which is attributed to the effects of the Pd NPs supported on reduced graphene oxide nanosheets. Meanwhile, the 1d catalyst can be easily separated from the reaction mixture by applying an external magnetic field. The catalyst was recycled over nine times without showing a significant loss in its activity. Such features enable this catalyst for promising application in catalysis, environment, and new energy fields.
    Dalton Transactions 04/2015; 44(19). DOI:10.1039/C5DT01036E · 4.10 Impact Factor
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    ABSTRACT: A new three-dimensional (3D) mesoporous hybrid framework was synthesized by coordinated layer-by-layer assembly between nanosheets of reduced graphene oxide and Fe3O4@Cu2O. This 3D mesoporous framework shows an excellent catalytic performance with a remarkable activity, selectivity (>99%), and strong durability in the synthesis of quinoxalines.
    Chemical Communications 02/2015; 51(24). DOI:10.1039/c5cc00250h · 6.72 Impact Factor
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    ABSTRACT: Recent studies have suggested that the physical and chemical properties of nanoparticles (NPs) strongly depend on local chemical composition, size, and shape. Here, we report a new precursor-mediated growth of monodisperse magnetic cobalt ferrite (CoFe2O4) NPs with controlled size and shape. CoFe2O4 NPs with near corner-grown cubic, near cubic and polyhedron shape can be successfully prepared by simply tuning the amount of iron and cobalt acetylacetonates in oleic acid. Interestingly, the product shape varies from near corner-grown cubic to starlike by only changing the reaction temperature from 320 degrees C to 330 degrees C. These CoFe2O4 NPs exhibit size and shape-dependent peroxidase-like activity towards 3,30,5,50-tetramethylbenzdine (TMB) in the presence of H2O2, and thus exhibited different levels of peroxidase-like activities, in the order of spherical > near corner-grown cubic > starlike > near cubic > polyhedron; this order was closely related to their particle size and crystal morphology. CoFe(2)O(4)NPs exhibited high stability in HAc-NaAc buffer (pH = 4.0) and high activity over a broad pH (2.5-6.0). Furthermore, the Michaelis constants K-m value for the CoFe2O4 NPs (0.006 mM) with TMB as the substrate was lower than HRP (0.062 mM) and Fe3O4 NPs (0.010 mM). After further surface functionalization with folic acid (FA), the folate-conjugated CoFe2O4 nanoparticles allow discrimination of HeLa cells (folate receptor overexpression) from NIH-3T3 cells (without folate receptor expression). Such investigation is of great significance for peroxidase nanomimetics with enhanced activity and utilization.
    RSC Advances 01/2015; 5(14). DOI:10.1039/C4RA15675G · 3.71 Impact Factor
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    ABSTRACT: Low cost, high activity and selectivity, convenient separation, and increased reusability are the main requirements for noble-metal-nanocatalyst-catalyzed reactions. Despite tremendous efforts, developing noble-metal nanocatalysts to meet the above requirements remains a significant challenge. Here we present a general strategy for the preparation of strongly coupled Fe3O4 and palladium nanoparticles (PdNPs) to graphene sheets by employing polyethyleneimine as the coupling linker. Transmission electron microscopic images show that Pd and Fe3O4 nanoparticles are highly dispersed on the graphene surface, and the mean particle size of Pd is around 3 nm. This nanocatalyst exhibits synergistic catalysis by Pd nanoparticles supported on reduced graphene oxide (rGO) and a tertiary amine of polyethyleneimine (Pd/Fe3O4/PEI/rGO) for the Tsuji–Trost reaction in water and air. For example, the reaction of ethyl acetoacetate with allyl ethyl carbonate afforded the allylated product in more than 99 % isolated yield, and the turnover frequency reached 2200 h−1. The yield of allylated products was 66 % for Pd/rGO without polyethyleneimine. The catalyst could be readily recycled by a magnet and reused more than 30 times without appreciable loss of activity. In addition, only about 7.5 % of Pd species leached off after 20 cycles, thus rendering this catalyst safer for the environment.
    Chemistry - A European Journal 09/2014; 20(36). DOI:10.1002/chem.201402545 · 5.70 Impact Factor
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    ABSTRACT: Ultrasensitive, accurate detection and separation of heavy metal ions is very important in environmental monitoring and biological detection. In this paper, a highly sensitive and specific detection method for Cu(2+) based on the fluorescence quenching of a europium(iii) hybrid magnetic nanoprobe is presented. This nanoprobe can detect Cu(2+) over a wide pH range (5.0-10.0) with a detection limit as low as 0.1 nM and it can be used for detecting Cu(2+) in living cells. After the magnetic separation, the Cu(2+) concentration decreased to 1.18 ppm, which is less than the US EPA drinking water standard (1.3 ppm), and more than 70% Cu(2+) could be removed when the amount of nanocomposite reached 1 mg.
    Nanoscale 08/2014; 6(19). DOI:10.1039/c4nr03454f · 6.74 Impact Factor
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    ABSTRACT: Successful development of magnetic nanoparticles (MNPs) with optimal size, shape, and composition is very desirable because they would increase the image contrast of magnetic resonance imaging (MRI). Here, we report a new precursor-mediated growth process of monodisperse MnFe2O4 NPs with controlled size and shape. MnFe2O4 NPs with plate-like shapes, spherical, and cubic can be successfully prepared by simply tuning the amount of Fe(acac)3 and Mn(acac)2 in oleic acid. Magnetism and MR properties of the particles were found to depend on their size and shape. These MnFe2O4 NPs, when conjugated with gadolinium and folic acid (FA), showed a simultaneous bright signal enhancement on the T1-weighted images and significant signal reduction on the T2-weighted image. In vitro MR imaging experiments also show that the developed multifunctional Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs enable targeted dual-contrast T1- and T2-weighted MR imaging of tumor cells over-expresses the folate receptor in vitro, and the T1- and T2-weighted MRI has been greatly improved. Our results clearly indicate that such an approach of forming multifunctional Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs is of great significance for T1- and T2-weighted MR imaging of specific cancer cells with high accuracy.
    07/2014; 2(29). DOI:10.1039/C4TB00342J
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    ABSTRACT: A simple Al(3+) sensor, 8-acetyl-7-hydroxy-4-methylcoumarin (AHMC), was synthesized. It can display an excellent fluorescence "turn-on" response to Al(3+) over other common metal ions in methanol-water media. Theoretical calculations have also been carried out to understand the configuration of the AHMC-Al complex and rationalize experimental absorption data.
    Dalton Transactions 01/2014; 43(7). DOI:10.1039/c3dt52414k · 4.10 Impact Factor
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    ABSTRACT: Abstract Background: In view of their high level of variability, autosomal short tandem repeats (STRs) are very useful as markers in the disciplines of forensic and population genetics studies. Aim: To investigate the diversity distributions of allelic frequencies of 15 loci from a sample from the Chinese Xibe ethnic group in Liaoning. Subjects and methods: Fifteen STR loci for 150 unrelated Xibe individuals from Liaoning, China were amplified simultaneously in a fluorescence-based reaction using a 2720 Thermal cycler (ABI). Separation and detection of the amplified product were conducted with the Li-COR 4300 DNA Analyzer. Results: In total, 117 alleles were observed, with the corresponding allele frequencies ranging from 0.001 to 0.507. D18S51 had the highest polymorphism (PIC = 0.840) among all 15 STR loci, whereas TPOX had the lowest (PIC = 0.590). The power of discrimination ranged from 0.801 for TH01 locus to 0.957 for D18S51 locus, whereas the power of exclusion ranged from a minimum 0.316 for TPOX locus to a maximum 0.720 for D21S11 locus. The phylogenetic tree established among worldwide populations showed that the Xibe population is far from other populations. Conclusion: Databases for the 15 STR loci will be useful for personal identification and paternity tests in the Xibe population and for the establishment of phylogenetic relationships between populations.
    Annals of Human Biology 11/2013; DOI:10.3109/03014460.2013.852245 · 1.15 Impact Factor
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    ABSTRACT: Background: Chromosome 19q13.3 has been identified as one of the regions that associate with cancer risk in previous studies. Methods: We systematically examined the 70.772kb region comprising four genes on chromosome 19q13.3 among Chinese using the haplotype-tagging SNP (htSNP) approach and the HapMap platform. The study involved 339 lung cancer cases and 358 non-cancer controls. Two htSNPs (rs1046282 and rs735482) captured most of the common haplotypes of CD3EA and the combined effects of sixteen htSNPs provided high coverage of common haplotypes of ERCC2, PPP1R13L, CD3EAP and ERCC1. Results: Both carriers of variant CC genotype [adjusted OR (95% CI)=1.28 (1.02-1.60), P=0.04] and variant C-allele among >20 years' smokers [OR (95% CI)=2.13 (1.24-3.67), P=0.006] for CD3EAP rs735482 were at increased risk of lung cancer. Four haplotype blocks of strong linkage disequilibrium were identified. The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk. MDR (multifactor dimensionality reduction) analysis demonstrated the best significant model of two-attributes containing smoking duration and rs2298881 in ERCC1 (P=0.004-0.005) and suggested that the effects of high-order interactions among smoking duration and ERCC2, PPP1R13, ERCC1 htSNPs could modulate lung cancer risk. Conclusions: HapMap-based study of 19q13.3 identified that genetic variation of CD3EAP and two loci were associated with lung cancer risk and interaction of smoking duration and genetic variants was the strongest predictor of lung cancer risk in a Chinese population.
    10/2013; 37(6). DOI:10.1016/j.canep.2013.09.016
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    ABSTRACT: The aim of this study was to estimate the allelic frequencies of the 19 STR loci with the Goldeneye™ DNA ID system 20A kit in a sample of 150 Manchu individuals from China to be used for forensic purposes and population studies. The observed heterozygosity(HO)values of these 19 STR loci ranged from 0.600 (D3S1358) to 0.914 (D18S51), the expected (HE) ranged from 0.615 (TPOX) to 0.876 (D16S1043). The power of discrimination (PD) values were found to range from 0.793 (TPOX) to 0.950 (D16S1043) and the probability of exclusion (PE) varies between 0.291 (D3S1358) and 0.825 (D18S51 and Penta E ). Among all the 19 loci, D16S1043 had the highest polymorphism (PIC=0.860), whereas TPOX had the lowest (PIC=0.550). For the 19 loci, the combined power of discrimination and the combined probability of exclusion are 0.9999999999999999999942 and 0.999999996777, respectively. The phylogenetic tree established among worldwide populations shows different populations who say the same language usually have a close genetic relationship with each other across the three language families studied (Sino-Tibetan, Altaic and Arabic).
    Gene 08/2013; 529(2). DOI:10.1016/j.gene.2013.07.033 · 2.08 Impact Factor
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    ABSTRACT: The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription. PPP1R13L and CD3EAP variants may be associated with cancer risk. We addressed the effects of variants/haplotypes of PPP1R13L rs1970764 and CD3EAP rs967591 and rs735482 on susceptibility of lung cancer among nonsmoking Chinese women. A hospital-based case-control study consisted of 79 lung cancer cases and 108 cancer-free controls matched by age (±3 years), gender, ethnicity and lifetime never-smoking. Genotyping and statistical analysis were performed by using the method of ligase detection reaction coupled with polymerase chain reaction (LDR-PCR) and SHEsis program and SPSS software. Presence of variant A-allele for CD3EAP rs967591 was associated with increase lung cancer risk [GA versus GG, OR (95% CI) = 2.53 (1.16-5.48), P = 0.02 and GA + AA versus GG, OR (95% CI) = 2.46 (1.16-5.20), P = 0.02]. Both D' values and r(2) values accorded with maker distances on chromosome 19q13.3. No associations were found for two other individual SNPs and haplotype distributions of three makers in the whole or single. In conclusion, this study suggests that CD3EAP rs967591 variant allele carriers are at increased susceptibility of lung cancer among nonsmoking Chinese women.
    Gene 04/2013; DOI:10.1016/j.gene.2013.04.017 · 2.08 Impact Factor
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    ABSTRACT: A multifunctional nanoprobe, which can be used for dual modal imaging and the detection of cancer cells, has been reported.
    Chemical Communications 04/2013; 49(43). DOI:10.1039/c3cc41984c · 6.72 Impact Factor
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    ABSTRACT: Fe(3)O(4) nanoparticles (NPs) decorated with rhodamine 6G Schiff base, which exhibit high selectivity and sensitivity toward Al(3+) over other common metal ions in aqueous media under a physiological pH window via a 1 : 1 binding mode, have been synthesized and characterized. The resulting conjugate renders the rhodamine 6G Schiff base unit more water soluble, and the detection limit reaches 0.3 ppb in water. Moreover, can detect Al(3+) in a wide pH span (5.0-11.0) and enrich/remove excess Al(3+) in water via an external magnetic field, which indicates that it has more potential and further practical applications for biology and toxicology. Furthermore, provides good fluorescent imaging of Al(3+) in living cells.
    Nanoscale 01/2013; 5(4). DOI:10.1039/c2nr33200k · 6.74 Impact Factor
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    ABSTRACT: A Ni(0)-catalyzed intermolecular cross-coupling of various functionalized thiols and aryl iodides has been developed and successfully extended to less explored intramolecular versions, where thioacetates could also be utilized as the strategic surrogate. Air-stable precatalysts, very mild conditions, and an easy protocol allow rapid access to medicinally useful aryl thioethers, as demonstrated in the facile synthesis of (±)-chuangxinmycin as a key step.
    Organic Letters 01/2013; 15(3). DOI:10.1021/ol303366u · 6.32 Impact Factor
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    ABSTRACT: The construction of reduced graphene oxide or graphene oxide (GO) with magnetic nanoparticles has gained more and more attention due to its promising and wide applications in catalysis, photoelectric materials, biomedical fields and so on. The synthesis of reduced graphene oxide (RGO) or graphene magnetic nanoparticle nanocomposites with well-dispersed decorated particles is still a challenge. Herein, we first report a simple method to prepare graphene–Fe3O4 with uniform Fe3O4 NPs based on decomposition of Fe(CO)5 on the surface of graphene oxide. The main novelty of this work is that the decomposition products of Fe(CO)5 reacted with GO leading to the formation of graphene–Fe3O4. The resulting sample can be easily manipulated by an external magnetic field and exhibits excellent catalytic activity in the A3-coupling reaction. A diverse range of propargylamines were obtained in a moderate to high yield under mild conditions. The separation and reuse of graphene–Fe3O4 were very simple, effective and economical.
    12/2012; 1(3):651-656. DOI:10.1039/C2TA00485B
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    ABSTRACT: The objective of this study is to understand pathogenesis of melamine-related kidney stone formation. We investigated the characterization of renal tubular cell under exposure to a mixture of melamine and cyanuric acid in vivo. Male Sprague-Dawley rats were separated into two experimental groups. Treatment group was administered daily with a standard commercial diet mixing with melamine and cyanuric acid, and control group was given a normal diet. Rat kidney specimens were stained with hematoxylin/eosin and the crystals were examined using a polarizing microscope. Renal tubular epithelial cells were observed by transmission electron microscopy. Semiquantitative RT-PCR assay was performed to determine monocyte chemoattractant protein-1 (MCP-1) mRNA expression, a protein in response to various proinflammatory stimuli. Apoptotic cells were examined by TUNEL assay. Melamine-associated crystals formed in glomerulus and wide renal tubule segment including proximal convoluted renal tubules, distal convoluted renal tubules, the limb loops of Henle and medullary collecting ducts in the cortex and medulla. Light microscopy results showed that the crystals lead to tubular lumen dilatation and tubular epithelial cell necrosis. It was observed that nucleus of renal tubular epithelial cells became irregular outlines and condensed, lysosomal-related structures increased, and integrity of renal tubule was deficient under electron microscopy. Apoptotic cells were noted widely in cortex and medulla. MCP-1 mRNA expression was significantly increased in the melamine and cyanuric acid-administrated group. Renal tubular epithelial cell injury, apoptosis and inflammation are involved in melamine-related kidney stone formation. Our findings are important for understanding pathogenesis of melamine-related kidney stone formation and estimating its clinical prognosis.
    Urological Research 09/2012; 40(6). DOI:10.1007/s00240-012-0507-x · 1.31 Impact Factor
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    ABSTRACT: DNA repair proficiency has also been proposed as a potential susceptibility factor for breast cancer. Synonymous polymorphism roles of the DNA repair genes in relation to breast cancer remain largely unknown. Nonsmokers are a good model in which to investigate genetic susceptibility to cancer because they are at low-dose carcinogen exposure. To validate genetic biomarkers of the disease, we explored the effects of the two synonymous polymorphisms [Pro206Pro (rs915927) and Arg156Arg (rs238406)] in the DNA repair genes XRCC1 and ERCC2 at chromosome 19q13.2-3 on breast cancer susceptibility among nonsmoking Chinese. The study recruited 243 patients with breast cancer and 234 cancer-free controls matched to the cases by age (±3years), gender, nonsmoking status and ethnicity. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism. No associations were observed between both individual single nucleotide polymorphisms or haplotypes and breast cancer susceptibility. After stratification, no effects were detected for age-dependent effects or menopause status in relation to breast cancer occurrence. No evidence of gene-gene interaction in breast cancer susceptibility was revealed. The two loci were at weak linkage disequilibrium (D' value=0.244, P=0.07). The present data suggest that XRCC1 Pro206Pro and ERCC2 Arg156Arg do not substantially influence breast cancer susceptibility among nonsmoking Chinese.
    Gene 05/2012; 503(1):118-22. DOI:10.1016/j.gene.2012.04.072 · 2.08 Impact Factor
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    ABSTRACT: The dynamical properties of liquid water play an important role in many processes in nature. In this paper, we focus on the infrared (IR) absorption spectrum of liquid water based on the linearized semiclassical initial value representation (LSC-IVR) with the local Gaussian approximation (LGA) [J. Liu and W. H. Miller, J. Chem. Phys. 131, 074113 (2009)] and an ab initio based, flexible, polarizable Thole-type model (TTM3-F) [G. S. Fanourgakis and S. S. Xantheas, J. Chem. Phys. 128, 074506 (2008)]. Although the LSC-IVR (LGA) gives the exact result for the isolated three-dimensional shifted harmonic stretching model, it yields a blueshifted peak position for the more realistic anharmonic stretching potential. By using the short-time information of the LSC-IVR correlation function; however, it is shown how one can obtain more accurate results for the position of the stretching peak. Due to the physical decay in the condensed phase system, the LSC-IVR (LGA) is a good and practical approximate quantum approach for the IR spectrum of liquid water. The present results offer valuable insight into future attempts to improve the accuracy of the TTM3-F potential or other ab initio-based models in reproducing the IR spectrum of liquid water.
    The Journal of Chemical Physics 12/2011; 135(24):244503. DOI:10.1063/1.3670960 · 3.12 Impact Factor
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    ABSTRACT: During endocytic vesicle formation, distinct subdomains along the membrane invagination are specified by different proteins, which bend the membrane and drive scission. Bin-Amphiphysin-Rvs (BAR) and Fer-CIP4 homology-BAR (F-BAR) proteins can induce membrane curvature and have been suggested to facilitate membrane invagination and scission. Two F-BAR proteins, Syp1 and Bzz1, are found at budding yeast endocytic sites. Syp1 arrives early but departs from the endocytic site before formation of deep membrane invaginations and scission. Using genetic, spatiotemporal, and ultrastructural analyses, we demonstrate that Bzz1, the heterodimeric BAR domain protein Rvs161/167, actin polymerization, and the lipid phosphatase Sjl2 cooperate, each through a distinct mechanism, to induce membrane scission in yeast. Additionally, actin assembly and Rvs161/167 cooperate to drive formation of deep invaginations. Finally, we find that Bzz1, acting at the invagination base, stabilizes endocytic sites and functions with Rvs161/167, localized along the tubule, to achieve proper endocytic membrane geometry necessary for efficient scission. Together, our results reveal that dynamic interplay between a lipid phosphatase, actin assembly, and membrane-sculpting proteins leads to proper membrane shaping, tubule stabilization, and scission.
    Proceedings of the National Academy of Sciences 11/2011; 108(44):E979-88. DOI:10.1073/pnas.1113413108 · 9.81 Impact Factor

Publication Stats

733 Citations
174.80 Total Impact Points


  • 2006–2014
    • Lanzhou University
      • State Key Laboratory of Applied and Organic Chemistry
      Kao-lan-hsien, Gansu Sheng, China
  • 2010–2013
    • Shenyang Medical College
      Feng-t’ien, Liaoning, China
    • University of Science and Technology, Beijing
      • Department of Environmental Engineering
      Peping, Beijing, China
  • 2006–2011
    • University of California, Berkeley
      • • Department of Chemistry
      • • Department of Molecular and Cell Biology
      Berkeley, MO, United States
  • 2007
    • CSU Mentor
      Long Beach, California, United States