Jian Ming

Publications (3)7.3 Total impact

• Article: Interaction of barley β-glucan and tea polyphenols on glucose metabolism in streptozotocin-induced diabetic rats.

  Ruiping Gao, Yu Wang, Zhen Wu, Jian Ming, Guohua Zhao
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  ABSTRACT: Soluble dietary fiber and antioxidants have received much attention as most important components of functional foods. However, few data are available on the effects of the combination of tea polyphenols (TP) and β-glucan (BG) on blood glucose in a diabetic rat. The effects of administration of barley BG and TP or their combination (TP + BG) on blood glucose, lipid profiles, and antioxidant parameters on streptozotocin-induced diabetic rats were investigated. Significant improvements on the blood glucose level, serum lipid parameters (decreases in triglyceride, total cholesterol, LDL-C, and increase in HDL-C), lipid peroxidation (decrease in malondiadehyde content), and serum antioxidant status (increases in superoxide dismutase, glutathione peroxidase, and total antioxidant capacity) resulted in diabetic rats after administering TP + BG. This study, therefore, demonstrated that the intake of TP + BG has beneficial effects on glucose tolerance, lipid metabolism, and serum antioxidant status. It also revealed that TP + BG is better than TP or BG alone in improving glucose metabolism and antioxidant status in diabetic rats. Practically, the present study suggested that polyphenols-rich cereal foods are help for type 2 diabetes. PRACTICAL APPLICATION: Although TP or BG was definitely helpful in the treatment and management of diabetes mellitus, synthetic anti-hyperglycemic effects were found between TP and BG. The fortification of a BG-rich cereal diet with TP could be used as a strategy to maintain health of diabetic subjects.
  Journal of Food Science 05/2012; 77(6):H128-34. · 1.66 Impact Factor
• Article: Characterization and antioxidant activity of the complex of tea polyphenols and oat β-glucan.

  Zhen Wu, Jian Ming, Ruiping Gao, Yuxue Wang, Qiang Liang, Huaguang Yu, Guohua Zhao
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  ABSTRACT: Few data are available about the effects of complexation of polyphenols with polysaccharide on their bioavailability. The complex of tea polyphenols (TP) with oat β-glucan was characterized by ultraviolet-visible spectrometry, Fourier transform infrared spectrometry, differential scanning calorimetry, atomic force microscopy, and solid-state (13)C NMR spectroscopy. The results indicated that the bonds which governed the interaction between TP and oat β-glucan were strong hydrogen bonds. The in vitro antioxidant activity of TP, β-glucan, their complex, and physical mixture was assessed using four systems, namely, DPPH(•), OH(•), and O(2)(•-) scavenging activities and reducing power. The complexation and blending of TP and β-glucan exhibited different impacts on the index of in vitro and in vivo antioxidant capacities. In the concentration range of 0.5-2.5 mg mL(-1), the complex had highest O(2)(•-) scavenging activity, whereas the highest OH(•) scavenging activity was found with the physical mixture. For antioxidant testing in vivo, there was no significant difference between the complex and the physical mixture in terms of glutathione peroxidase activity and levels of malondialdehyde and total antioxidant capacity in serums. However, the complex exhibited much higher activities of superoxide dismutase and glutathione peroxidase in livers than the physical mixture. The present study provided a deeper understanding of the influence of molecular interaction between TP and oat β-glucan on their antioxidant activities.
  Journal of Agricultural and Food Chemistry 09/2011; 59(19):10737-46. · 2.82 Impact Factor
• Article: Optimization of adsorption of tea polyphenols into oat β-glucan using response surface methodology.

  Zhen Wu, Hong Li, Jian Ming, Guohua Zhao
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  ABSTRACT: Information on interactions between oat β-glucan and tea polyphenols (TP) is not available in the published literatures. Equilibrium dialysis was applied to determine the adsorption of TP into β-glucan, and response surface methodology (RSM) was employed to optimize the absorbing variables (pH, temperature, and phosphate buffered saline (PBS) buffer concentration). The equilibrium data at constant temperature were fitted with the Langmuir, Freundlich, and Redlich-Peterson models. The results showed that the Freundlich model was the best method to describe the experimental data. Parabolic curves were obtained for pH and temperature. In terms of adsorption capacity, factors including temperature, pH/temperature, and buffer concentration/temperature had the greatest influence on the response. The highest adsorption capacity of TP into β-glucan was 134.55 μg mg(-1) at the following optimized conditions: pH 5.56, PBS buffer concentration 0.13 M, and temperature 40 °C. No significant differences (p > 0.05) between the experimental and predicted values confirmed the adequacy of the response surface equations.
  Journal of Agricultural and Food Chemistry 01/2011; 59(1):378-85. · 2.82 Impact Factor