Jenher Jeng

Publications (3)12.33 Total impact

• Source

  Available from: Ching-Sheng Hsu

  Article: Association of IL28B genotypes with metabolic profiles and viral clearance rate in chronic hepatitis C patients

  Ching-Sheng Hsu, Shih-Jer Hsu, Hung-Chia Chen, Chen-Hua Liu, Jenher Jeng, Chun-Jen Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
  Hepatology International 01/2012; · 2.64 Impact Factor
• Source

  Available from: Ching-Sheng Hsu

  Article: Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.

  Ching-Sheng Hsu, Shih-Jer Hsu, Hung-Chia Chen, Tai-Chung Tseng, Chen-Hua Liu, Wei-Fang Niu, Jenher Jeng, Chun-Jen Liu, Ming-Yang Lai, Pei-Jer Chen, Jia-Horng Kao, Ding-Shinn Chen
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  ABSTRACT: Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear. We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin for the study. Blood samples were taken more frequently at defined intervals in the first 3 d. Peg-IFN was administered at week 1. It was then administered weekly in combination with daily ribavirin for 24 or 48 wk. A mathematical model fitted to the observed HCV kinetics was constructed, which could interpret the transient HCV titer elevation after Peg-IFN treatment. The results demonstrated a comparable viral clearance rate (c = 3.45 ± 3.73) (day(-1), mean ± SD) but lower daily viral production rate (P = 10(6)-10(12)) in our patients than those reported previously in Western patients. Of 110 patients with a sustained virological response (SVR), 47 (43%) had a transient elevation of viral titer within 12 h (proportion of 12 h/3 d: 44% in non-SVR vs. 70% in SVR; P = 0.029). Among 91 patients with available rs8099917 data, patients with the TT genotype had an early surge of viral titer after therapy and a higher SVR and viral clearance rate than those with the GT genotype. In conclusion, Taiwanese patients with CHC receiving Peg-IFN plus ribavirin therapy have a lower daily viral production rate than Western patients, and the rs8099917 TT genotype may contribute to the increased viral clearance rate and better virological responses in these patients.
  Proceedings of the National Academy of Sciences 02/2011; 108(9):3719-24. · 9.68 Impact Factor
• Chapter: Canonical Dynamics Mechanism of Monetary Policy and Interest Rate

  Jenher Jeng, Wei-Fang Niu, Nan-Jye Wang, Shih-Shan Lin
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  ABSTRACT: Interest rates are the fundamental elements of financial and economic activities, and their movements are the major risk factors driving the global capital flows. In the United States, the central bank (Federal Reserve Bank) uses the Fed Funds Rate (FFR, the overnight borrowing rate between banks) as the key tool to anchor its monetary policy for maintaining both sustainable growth and price stability. It has been a sophisticated art and science for the Federal Open Market Committee (FOMC, the primary unit of the FRB for setting the FFR) to balance growth and inflation by tuning the FFR. Among a few models trying to quantitatively assess the FOMC’s efforts on FFR determination is the popular Taylor Rule (Taylor (1993)) for best outlining the thoughts of arguments from the beginning. This paper is based on the R&D works from the Seminar On Adaptive Regression (SOAR) jointly sponsored by G5 Capital Management, LLC. and SIFEON, Ltd., which is founded by Dr. Jeng (Ph.D. of Statistics, UC Berkeley). We would like to thank all the members who contributed to numerous discussions and simulations in SOAR.
  12/2007: pages 417-441;