Javed Iqbal

Publications (8)24.04 Total impact

• Article: Synthesis of novel therapeutic agents for the treatment of multiple sclerosis: A brief overview.

  Naveen Mulakayala, Pallavi Rao, Javed Iqbal, Rakeshwar Bandichhor, Srinivas Oruganti
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  ABSTRACT: Multiple sclerosis (MS) often results in chronic inflammatory and autoimmune disorders, and recent developments in understanding the disease pathogenesis has lead to newer therapeutic options for the treatment of the disease. The development of small molecule drugs with improved efficacy, better tolerability, and oral administration has received a new impetus with the discovery of newer classes of drugs. In this review, we have summarized the hitherto known synthetic strategies of fingolimod, laquinimod, cladribine, and teriflunomide reported in the literature which are the key small molecules and the first oral drug candidates for MS in various stages of clinical development or have been launched in the market.
  European journal of medicinal chemistry 11/2012; 60C:170-186. · 3.27 Impact Factor
• Article: InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.

  Naveen Mulakayala, Bhaskar Kandagatla, Ismail, Rajesh Kumar Rapolu, Pallavi Rao, Chaitanya Mulakayala, Chitta Suresh Kumar, Javed Iqbal, Srinivas Oruganti
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  ABSTRACT: A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl(3) with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules.
  Bioorganic & medicinal chemistry letters 06/2012; 22(15):5063-6. · 2.65 Impact Factor
• Article: Sequential coupling/desilylation-coupling/cyclization in a single pot under Pd/C-Cu catalysis: synthesis of 2-(hetero)aryl indoles.

  R Mohan Rao, Upendar C H Reddy, Alinakhi, Naveen Mulakayala, Mallika Alvala, M K Arunasree, Rajamohan R Poondra, Javed Iqbal, Manojit Pal
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  ABSTRACT: A new one-pot synthesis of 2-(hetero)aryl indoles via sequential C-C coupling followed by C-Si bond cleavage and a subsequent tandem C-C/C-N bond forming reaction is described. A variety of functionalized indole derivatives were prepared by conducting this four step reaction under Pd/C-Cu catalysis. The methodology involved coupling of (trimethylsilyl)acetylene with iodoarenes in the presence of 10% Pd/C-CuI-PPh(3) and triethylamine in MeOH, followed by treating the reaction mixture with K(2)CO(3) in aqueous MeOH, and finally coupling with o-iodoanilides. The single crystal X-ray data of a synthesized indole derivative is presented. Application of the methodology, in vitro pharmacological properties of the synthesized compound, along with a docking study is described.
  Organic & Biomolecular Chemistry 03/2011; 9(10):3808-16. · 3.70 Impact Factor
• Article: Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes.

  Mohosin Layek, Appi Reddy M, A V Dhanunjaya Rao, Mallika Alvala, M K Arunasree, Aminul Islam, K Mukkanti, Javed Iqbal, Manojit Pal
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  ABSTRACT: A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.
  Organic & Biomolecular Chemistry 02/2011; 9(4):1004-7. · 3.70 Impact Factor
• Article: A convergent synthesis of the macrolide core of migrastatin

  V. Sai Baba, Parthasarathi Das, K. Mukkanti, Javed Iqbal
  Tetrahedron Letters 47(34):6083-6086. · 2.68 Impact Factor
• Article: Stereoselective synthesis of the C1–C10 fragment of rhizoxin D

  Srinivas Padakanti, Manojit Pal, K. Mukkanti, Javed Iqbal
  Tetrahedron Letters 47(33):5969-5971. · 2.68 Impact Factor
• Article: Synthesis of γ-N-acylamino-β-keto esters and ethyl 5-oxazoleacetates via Ritter reaction and hydration of γ-hydroxy-α,β-alkynoic esters

  K. Srinivasa Rao, D. Srinivasa Reddy, Manojit Pal, K. Mukkanti, Javed Iqbal
  Tetrahedron Letters 47(26):4385-4388. · 2.68 Impact Factor
• Article: Studies towards the total synthesis of (−)-borrelidin: a strategy for the construction of the C11–C15 cyanodiene fragment and the utility of RCM for macrocyclization using model systems

  C. Vamsee Krishna, Santanu Maitra, R. Vasu Dev, K. Mukkanti, Javed Iqbal
  Tetrahedron Letters 47(34):6103-6106. · 2.68 Impact Factor