J De Bellescize

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Publications (2)4.67 Total impact

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    Article: Atypical hemispheric asymmetries for the processing of phonological features in children with rolandic epilepsy.
    Nathalie Bedoin, Emmanuel Ferragne, Céline Lopez, Vania Herbillon, J De Bellescize, Vincent des Portes
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    ABSTRACT: We assessed language lateralization in 177 healthy 4- to 11-year-old children and adults and atypical asymmetries associated with unilateral epileptic foci in 18 children with benign epilepsy with centrotemporal spikes (BECTS). Dichotic listening results revealed two indices of immature functional asymmetry when the focus was left-sided (BECTS-L). First, children with BECTS-L did not show left hemisphere dominance for the processing of place of articulation, which was recorded in children with BECTS-R and control children. On the contrary, healthy children exhibited a gradual increase in left hemisphere dominance for place processing during childhood, which is consistent with the shift from global to finer-grained acoustic analysis predicted by the Developmental Weighting Shift model. Second, children with BECTS-L showed atypical left hemisphere involvement in the processing of the voiced value (+V), associated with a long acoustic event in French stop consonants, whereas right hemisphere dominance increased with age for +V processing in healthy children. BECTS-L, therefore, interferes with the development of left hemisphere dominance for specific phonological mechanisms.
    Epilepsy & Behavior 04/2011; 21(1):42-51. · 2.34 Impact Factor
  • Article: Hemispheric lateralization of cognitive functions in children with centrotemporal spikes.
    N Bedoin, V Herbillon, I Lamoury, P Arthaud-Garde, K Ostrowsky, J De Bellescize, P Kéo Kosal, G Damon, Ch Rousselle
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    ABSTRACT: We assessed the impact of unilateral epileptic foci in benign idiopathic partial epilepsy of childhood with rolandic discharges (BECT) on performance and hemispheric specialization in lateralized cognitive functions. Six children with BECT with a left-sided focus (BECT-L), 6 children with BECT with a right-sided focus (BECT-R), and 12 control children were tested in verbal, visual-spatial, and visual-attention tasks, with visual hemifield presentation. Children with BECT-R were impaired in the visual-spatial task relative to those with BECT-L, and the typical left-hemisphere (LH) advantage was not reported in the verbal task in children with BECT-L. Additionally, the classic global superiority effect was lacking in children with BECT-R, which may be due to impaired performance of the right hemisphere specialized in global (vs local)-level processing. These data argue for the deleterious effect of epileptic discharges per se on cognitive functions in the developing brain, and the decisive role of epileptic focus lateralization in specific cognitive impairments and hemispheric specialization.
    Epilepsy & Behavior 10/2006; 9(2):268-74. · 2.34 Impact Factor
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