Niraikulam Ayyadurai,
Nadarajan Saravanan Prabhu,
Kanagavel Deepankumar,
Yoon Jung Jang,
Nataraj Chitrapriya,
Eunjung Song,
Nahum Lee,
Seog K Kim,
Byung-Gee Kim,
Nagasundarapandian Soundrarajan,
Sungu Lee, Hyung Joon Cha,
Nediljko Budisa,
Hyungdon Yun
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ABSTRACT: We describe the simple bioconjugation strategy in combination of periodate chemistry and unnatural amino acid incorporation. The residue specific incorporation of 3,4-dihydroxy-l-phenylalanine can alter the properties of protein to conjugate into the polymers. The homogeneously modified protein will yield quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for widespread use to prepare protein conjugates and synthetic biology applications.
Bioconjugate Chemistry 03/2011; 22(4):551-5. · 4.93 Impact Factor
