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ABSTRACT: Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990s, molecular studies of these transporters have revealed a wealth of information about the transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA, and perhaps transporter trafficking regulation for a number of highly relevant diseases including substance abuse, depression, schizophrenia, and Parkinson's disease.
Progress in molecular biology and translational science 01/2011; 98:1-46.
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ABSTRACT: A method of retrieving thermophysical depth profiles of continuously inhomogeneous materials is presented both theoretically and experimentally using the three-dimensional (3-D) photothermal radiometry. A 3-D theoretical model suitable for characterizing solids with arbitrary continuously varying thermophysical property depth profiles and finite (collimated or focused) laser beam spotsize is developed. A numerical fitting algorithm to retrieve the thermophysical profile was demonstrated with three case hardened steel samples. The reconstructed thermal conductivity depth profiles were found to be well anti-correlated with microhardness profiles obtained with the conventional indenter method.
Journal of Physics Conference Series 04/2010; 214(1):012087.
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ABSTRACT: A method of retrieving thermophysical depth profiles of continuously inhomogeneous materials is presented both theoretically and experimentally using laser infrared photothermal radiometry. This method represents the three-dimensional (3D) extension of earlier one-dimensional thermal-wave inverse-problem techniques for reconstructing inhomogeneous thermal-conductivity or diffusivity depth profiles. A 3D theoretical model suitable for characterizing solids with arbitrary continuously varying thermophysical property depth profiles and finite (collimated or focused) laser beam spotsize is developed. A numerical fitting algorithm to retrieve the thermophysical profile was demonstrated with three case hardened steel samples. The reconstructed thermal conductivity depth profiles were found to be well anticorrelated with microhardness profiles obtained with the conventional indenter method.
Journal of Applied Physics 01/2009; · 2.17 Impact Factor
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ABSTRACT: Researches on neural population coding have revealed that continuous stimuli, such as orientation, moving direction, and the spatial location of objects could be encoded as continuous attractors in neural networks. The dynamical behaviors of continuous attractors are interesting properties of recurrent neural networks. This paper proposes a class of recurrent neural networks without lateral inhibition. Since there is no general rule to determine the stability of the network without specifying the excitatory connections, individual conditions can be calculated analytically for some particular cases. It shows that the networks can possess continuous attractors if the excitatory connections are in gaussian shape. Simulation examples are employed for illustration.
Cybernetics and Intelligent Systems, 2008 IEEE Conference on; 10/2008
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ABSTRACT: This paper presents a fuzzy Choquet integral approach which is used to evaluate the capability of supplier and then to deal with the supplier selection problem. Firstly, the basic of fuzzy measures and Choquet integral are introduced. Secondly, linguistic terms expressed in trapezoidal fuzzy numbers are used to assess the ratings for the suppliers' quality and the importance of criteria. Then, an evaluation model based on the fuzzy measure and Choquet integral theory is proposed, and we give the detailed procedure with an example. This paper shows that the proposed model is very well suited as an evaluation tool for supplier selection decisions.
Wireless Communications, Networking and Mobile Computing, 2007. WiCom 2007. International Conference on; 10/2007
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ABSTRACT: The growing emphasis on pervasive computing and MEMS requires the deployment the computation on very small devices for swarming system. The cooperation and interaction in such system inspired by biological system seem to be more and more complex and inconceivable because of highly dynamic, distributed and unpredicted features. The common stigmergy in biological decentralized system characterizes the important process that the individual agents indirectly interact with an environment by making changes to it. Through context-aware, these changes can raise the emergence that makes the swarming system more coherent, adaptive and robust. Understanding and exploiting emergence is key to study and engineer global coherent behavior in pervasive computing. This paper describes the process of emergence arisen from stigmergy in swarming, and present the fundamental mathematic method to gain more deeply insight of emergence. An experience was showed to prove that nonlinear dynamics and chaos time series analysis are one of the promising interdisciplinary methods that can provide the insights on producing and controlling emergence in pervasive computing environment
Pervasive Computing and Applications, 2006 1st International Symposium on; 09/2006
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ABSTRACT: The influence of the photothermal laser source beam size on the measurement sensitivity of layered systems using photothermal radiometry PTR is presented. Based on an appropriate theoretical model, widely different behaviors of the photothermal amplitude and phase in terms of combinations of thermophysical properties i.e., thermal conductivity and thermal diffusivity between a thin coating and the substrate are observed. The beam size effect on PTR measurement sensitivity is theoretically examined and experimentally demonstrated using a carbonitrided C1018 steel sample. The experimental results of using a variable size laser beam for the carbonitrided C1018 sample validate the theoretical prediction, in which an expanded beam exhibits a much larger magnitude change in both amplitude and phase as a function of frequency than measurements with a focused beam. The fitted thermal conductivity and thermal diffusivity based on the assumed industrially relevant range of effective hardness case depth gives the approximate range of the change in thermal conductivity and thermal diffusivity of C1018 steels after the carbonitriding process. © 2008 American Institute of Physics.
