Huazhen Jia

Publications (2)10.75 Total impact

• Article: Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.

  Hongjin Song, Wen Yin, Qian Zeng, Huazhen Jia, Li Lin, Xiaodong Liu, Lingyun Mu, Rui Wang
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  ABSTRACT: Substance P as a member of tachykinin family plays an important role in angiogenesis. Hemokinins (HKs) have been identified as new members of substance P-like peptides of tachykinin family. However, the effects of HKs on endothelial cells and angiogenesis have not been studied. For the first time, here we demonstrated that r/mHK-1, hHK-1 and hHK(4-11) dose-dependently stimulated the proliferation, migration, adhesion and tube formation of freshly isolated human umbilical vein endothelial cells (HUVECs), and further exhibited in vivo angiogenic effects in chick embryo chorioallantoic membrane model. The angiogenic effects of HKs were inhibited by the selective antagonist of neurokinin-1 rather than neurokinin-2 receptor. Mechanistically, HKs activated ERK1/2 phosphorylation, stimulated nitric oxide production, and upregulated the expression of endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) in HUVECs. Taken together, our data suggest that HKs emerge as pivotal endogenous regulators of angiogenesis and represent potential targets for the intervention of angiogenesis in different pathological conditions given their specific peripheral distribution.
  The international journal of biochemistry & cell biology 04/2012; 44(9):1410-21. · 4.89 Impact Factor
• Article: Asymmetric aza-Mannich addition: synthesis of modified chiral 2-(ethylthio)-thiazolone derivatives with anticancer potency.

  Xiaodong Liu, Leijiao Deng, Hongjin Song, Huazhen Jia, Rui Wang
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  ABSTRACT: An easily prepared cinchona alkaloid derivative was found to be an effective organocatalyst in a direct, enantioselective aza-Mannich addition. By establishing a quaternary carbon stereocenter, a series of modified chiral 2-(ethylthio)-thiazolone derivatives have been obtained with excellent diastereo- and enantioselectivities. And these derivatives have been found to show anticancer activities against five different cancer cell lines using the MTT assay.
  Organic Letters 02/2011; 13(6):1494-7. · 5.86 Impact Factor