Hendrik I J Roest

Publications (3)20.38 Total impact

• Article: Coxiella burnetii infection in roe deer during Q fever epidemic, the Netherlands.

  Jolianne M Rijks, Hendrik I J Roest, Peter W van Tulden, Marja J L Kik, Jooske IJzer, Andrea Gröne
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  ABSTRACT: TO THE EDITOR: A Q fever epidemic among humans started in the Netherlands in 2007 and peaked in 2009 (1). Epidemiologic evidence linked the epidemic to abortions and deliveries among Coxiella burnetii-infected dairy goats and dairy sheep (1,2). However, questions arose about whether C. burnetii infection in free-living wildlife might be another source of Q fever in humans. C. burnetii has a wide host range (3), but to our knowledge no studies had addressed its occurrence in nondomestic animals in the Netherlands (4).
  Emerging Infectious Diseases 12/2011; 17(12):2369-71. · 6.79 Impact Factor
• Article: Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands.

  Hendrik I J Roest, Robin C Ruuls, Jeroen J H C Tilburg, Marrigje H Nabuurs-Franssen, Corne H W Klaassen, Piet Vellema, René van den Brom, Daan Dercksen, Willem Wouda, Marcel A H Spierenburg, Arco N van der Spek, Rob Buijs, Albert G de Boer, Peter Th J Willemsen, Fred G van Zijderveld
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  ABSTRACT: Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.
  Emerging Infectious Diseases 04/2011; 17(4):668-75. · 6.79 Impact Factor
• Source

  Available from: Lenny Hogerwerf

  Article: Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands.

  Lenny Hogerwerf, René van den Brom, Hendrik I J Roest, Annemarie Bouma, Piet Vellema, Maarten Pieterse, Daan Dercksen, Mirjam Nielen
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  ABSTRACT: Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii.
  Emerging Infectious Diseases 03/2011; 17(3):379-86. · 6.79 Impact Factor