Goulin Zhang

Zhejiang University, Hang-hsien, Zhejiang Sheng, China

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Publications (1)1.9 Total impact

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    ABSTRACT: Three series of flavonoid derivatives were designed and synthesized. All synthesized compounds were evaluated for cytotoxic activities against five human cancer cell lines, including K562, PC-3, MCF-7, A549, and HO8910. Among the compounds tested, compound 9 d exhibited the most potent cytotoxic activity with IC(50) values of 2.76-6.98 μM. Further comparative molecular field analysis was performed to conduct a 3D quantitative structure-activity relationship study. The generated 3D-QSAR model could be used for further rational design of novel flavonoid analogs as highly potent cytotoxic agents.
    Molecular Diversity 11/2010; 15(3):665-75. DOI:10.1007/s11030-010-9289-7 · 1.90 Impact Factor

Publication Stats

4 Citations
1.90 Total Impact Points

Top Journals


  • 2010
    • Zhejiang University
      • College of Pharmaceutical Sciences
      Hang-hsien, Zhejiang Sheng, China