Gillian S Smelick

Publications of Gillian S Smelick

• Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator.

  Authors: Evan W Miller, Nicolas Taulet, Carl S Onak, Elizabeth J New, Julie K Lanselle, Gillian S Smelick, Christopher J Chang

  Journal of the American Chemical Society. 11/2010;

  Hydrogen peroxide (H(2)O(2)) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe forHydrogen peroxide (H(2)O(2)) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H(2)O(2) on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H(2)O(2) as well as remote control of cell behavior via H(2)O(2)-mediated pathways.