Flávia Negromonte Souto Maior

Publications (2)4.92 Total impact

• Article: Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models.

  Flávia Negromonte Souto-Maior, Fabíola Lélis de Carvalho, Liana Clébia Soares Lima de Morais, Sueli Mendonça Netto, Damião Pergentino de Sousa, Reinaldo Nóbrega de Almeida
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  ABSTRACT: Linalool oxide is a monoterpene that is found in some species of aromatic plants. The effects of the inhalation of linalool oxide (0.65%, 1.25%, 2.5% and 5.0% w/w) in the elevated plus-maze and light/dark box tests as animal models of anxiety were investigated in adult male mice and compared with the effects of the reference anxiolytic diazepam (0.5 and 2.0 mg/kg), administered intraperitoneally. Additionally, the effects of inhaled linalool oxide were investigated in the rotarod test. Linalool oxide significantly increased the number of visits to the open arms of the elevated plus-maze and the amount of time spent there as well as the total number of entries. In the light/dark box test, inhalation of linalool oxide led to an increase in the time spent by the mice in the brightly-lit chamber and in the number of times the animal crossed from one compartment to another. Performance on the rotarod was unaffected. Thus, inhaled linalool oxide was found to have anxiolytic properties in both animal models, without causing any motor deficit. These results suggest that inhalation of linalool oxide may be a useful means of counteracting anxiety.
  Pharmacology Biochemistry and Behavior 09/2011; 100(2):259-63. · 2.53 Impact Factor
• Source

  Available from: Maria De Fátima Agra

  Article: Essential oils and their constituents: anticonvulsant activity.

  Reinaldo Nóbrega de Almeida, Maria de Fátima Agra, Flávia Negromonte Souto Maior, Damião Pergentino de Sousa
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  ABSTRACT: A literature-based survey of plants species and their essential oils with anticonvulsant activity was carried out. As results, 30 species belonging to 13 families and 23 genera were identified for their activities in the experimental models used for anticonvulsant drug screening. Thirty chemical constituents of essential oils with anticonvulsant properties were described. Information on these 30 species is presented together with isolated bioactive compound studies.
  Molecules 01/2011; 16(3):2726-42. · 2.39 Impact Factor