Publications (2)3.23 Total impact
Article: Toxic effects of a high dose of non-ionic iodinated contrast media on renal glomerular and aortic endothelial cells in aged rats in vivo.[show abstract] [hide abstract]
ABSTRACT: Iodinated contrast media (CM) can induce apoptosis and necrosis of renal tubular cells. The injuries of endothelial cells induced by CM on the systemic condition have not been fully understood. To assess the toxic effects of non-ionic CM on the glomerular and aortic endothelial cells, iopromide and iodixanol, two kinds of representative non-ionic CM, were used for the in vivo study. Sixty aged rats were respectively received the agents or normal sodium intravascularly. No obvious apoptosis and morphological change was detected in the glomerular and aortic endothelial cells apart from renal tubules after CM administration. However, expressions of the nitric oxide synthase (eNOS) in glomerular endothelium were decreased at 12h after CM injection. Furthermore, plasma creatinine and endothelin-1 were increased and plasma nitric oxide (NO) was decreased significantly after CM administration. However, we failed to observe the significant increase of plasma von Willebrand Factor. These results suggest that non-ionic iodinated CM do not induce apoptosis and necrosis of glomerular and aortic endothelial cells in vivo. Decreased eNOS expression and increased plasma endothelin-1 may be involved in non-ionic iodinated CM-induced endothelial dysfunction and kidney injury.Toxicology Letters 02/2011; 202(3):253-60. · 3.23 Impact Factor
Article: [Relationship between insulin resistance and cardiovascular risk factors clustering: an epidemiological study].[show abstract] [hide abstract]
ABSTRACT: To study the relationship between insulin resistance and cardiovascular risk factor clustering. The height, body weight, waist circumference, and hip circumference were measured, and fasting venous blood was drawn among 1 196 rural residents, 533 males (44.57%) and 663 females (55.43%), aged 35 approximately 59 with the average age of 46.69, in Pizhou City, Jiangsu Province, selected by random sampling. Fasting serum true insulin (TI) was determined by ELISA. Blood lipids were measured by completely automatic biochemical analyzer. Homeostasis model assessment (HOMA) index was calculated and used as the indicator to evaluate insulin resistance. The statistic methods, such as Spearman correlation, partial correlation and multivariate Logistic regression were used to study the relationship between insulin resistance and hypertension, overweight, visceral obesity, dyslipidemia and cardiovascular risk factors clustering. The median (Q(R)) of TI and HOMA index were 4.89 (3.02 approximately 7.09) mIU/L and 0.98 (0.57 approximately 1.44) respectively, and TI and HOMA index of the female subjects were significantly higher than those of the male subjects (P < 0.01). The correlation coefficient between HOMA index and cardiovascular risk factors number was 0.290 (P < 0.01) by Spearman correlation analysis and 0.177 6 (P < 0.01) by partial correlation analysis after adjustment by age, sex, body mass index and waist circumference respectively. The results of non-conditional multivariate stepwise Logistic regression indicated that insulin resistance associated with cardiovascular risk factors aggregation and was independent of age, sex, body mass index and waist circumference, and the odds ratio (95% CI) was 1.250 (1.089 approximately 1.434). Insulin resistance may be a common pathogenetic mechanism of cardiovascular risk factor dustering.Zhonghua yi xue za zhi 09/2002; 82(17):1183-6.