Cuno Spm Uiterwaal

Publications (2)13.34 Total impact

• Article: Survival effects of prenatal famine exposure.

  Annet F M van Abeelen, Marjolein V E Veenendaal, Rebecca C Painter, Susanne R de Rooij, Marcel G W Dijkgraaf, Patrick M M Bossuyt, Sjoerd G Elias, Diederick E Grobbee, Cuno S P M Uiterwaal, Tessa J Roseboom
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  ABSTRACT: Adverse intrauterine conditions are known to be associated with an increased risk of chronic diseases in adult life. Previously, we showed that prenatal famine exposure increased the incidence of cardiovascular and metabolic disease in adulthood. We examined the association between prenatal famine exposure and adult mortality. We studied adult mortality among 1991 term singletons from the Dutch Famine Birth Cohort. We compared overall and cause-specific adult mortality among people exposed to famine in late, mid, and early gestation with those unexposed to famine in utero by using Cox proportional hazard models. A total of 206 persons (10%) had died by the end of follow-up. Compared with unexposed women, women exposed to famine in early gestation had a significantly higher risk of overall adult mortality (HR: 1.9; 95% CI: 1.1, 3.4), cardiovascular mortality (HR: 4.6; 95% CI: 1.2, 17.7), cancer mortality (HR: 2.3; 95% CI: 1.1, 4.7), and breast cancer mortality (HR: 8.3; 95% CI: 1.1, 63.0). In men exposed to famine in early gestation, these associations were as follows compared with unexposed men: overall adult mortality (HR: 0.4; 95% CI: 0.2, 1.1), cardiovascular mortality (HR: 0.9; 95% CI: 0.3, 3.1), and cancer mortality (HR: 0.3; 95% CI: 0.0, 1.9). Women exposed to famine in early gestation had a higher overall adult, cardiovascular, cancer, and breast cancer mortality risk than did women not exposed to famine. No such effects were observed in men exposed to famine in early gestation.
  American Journal of Clinical Nutrition 12/2011; 95(1):179-83. · 6.67 Impact Factor
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  Available from: uu.nl

  Article: The association between breastfeeding and the cardiovascular system in early childhood.

  Annemieke M V Evelein, Caroline C Geerts, Frank L J Visseren, Michiel L Bots, Cornelis K van der Ent, Diederick E Grobbee, Cuno S P M Uiterwaal
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  ABSTRACT: Breastfeeding is suggested to have beneficial effects on children's health and future health status. However, its cardiovascular effects in childhood and possibly later in life remain largely unclear. The aim of the present study was to determine the cardiovascular effects of exclusive breastfeeding in early childhood. We used the ongoing WHeezing Illnesses STudy LEidsche Rijn (WHISTLER) birth cohort to obtain data on infant feeding. In the first 306 children who were 5 y of age, ultrasonographic measurements of the carotid artery were performed to obtain carotid intima-media thickness (CIMT), distensibility, and elastic modulus. At 5 y of age, children who had been exclusively breastfed in infancy for 3 to 6 mo had a CIMT that was 21.1 μm greater than that of exclusively formula-fed children (95% CI: 5.0, 37.2 μm; P = 0.01, adjusted for confounders). CIMT was not significantly different between children exclusively breastfed for either <3 or >6 mo and formula-fed children. In addition, no significant differences in carotid stiffness were observed between groups. The duration of exclusive breastfeeding in infancy is related to properties of the carotid arterial wall at the age of 5 y, as shown by the greater CIMT in children who were exclusively breastfed for 3 to 6 mo. This relation was independent of early growth in infancy and current cardiovascular disease risk factors. The choice of infant feeding appears to have an effect on the vascular system already in early childhood.
  American Journal of Clinical Nutrition 02/2011; 93(4):712-8. · 6.67 Impact Factor