Robert Engel,
Ishrat Ghani,
Diego Montenegro,
Marie Thomas,
Barbara Klaritch-Vrana,
Alejandra Castaño,
Laura Friedman,
Jay Leb,
Leah Rothman,
Heidi Lee,
Craig Capodiferro,
Daniel Ambinder,
Eva Cere, Christopher Awad,
Faiza Sheikh,
Jaimelee Rizzo,
Lisa-Marie Nesbitt,
Erika Testani,
Karin Melkonian
[show abstract]
[hide abstract]
ABSTRACT: Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Molecules 01/2011; 16(2):1508-18. · 2.39 Impact Factor
