Xiaodong Jin,
Zhi Hu,
Yan Kang,
Chang Liu,
Yongfang Zhou,
Xiaodong Wu,
Jin Liu,
Mingxing Zhong, Chuanxing Luo,
Lijing Deng,
Yiyun Deng,
Xiaoqi Xie,
Zhongwei Zhang,
Yan Zhou,
Xuelian Liao
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ABSTRACT: We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions. IL-10-1082 promoter polymorphisms were analyzed with polymerase chain reaction amplification followed by restriction fragment length polymorphism. Mortality was recorded if it occurred within 30 days from admission. The -1082G/G genotype was associated with lower frequency of ARDS (odds ratios=0.51; 95% confidence intervals: 0.34-0.76; p=0.001), and in patients with ARDS, it was associated with lower mortality within 30 days (odds ratios=0.44; 95% confidence intervals: 0.25-0.76; p=0.003) than in controls. We conclude that IL-10-1082 G/G genotype is associated with a decreased rate development of ARDS and mortality in this Chinese population.
Genetic Testing and Molecular Biomarkers 12/2010; 15(4):203-6. · 1.11 Impact Factor