Chuanxing Luo

Publications (2)4.04 Total impact

• Article: Association of IL-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population.

  Xiaodong Jin, Zhi Hu, Yan Kang, Chang Liu, Yongfang Zhou, Xiaodong Wu, Jin Liu, Mingxing Zhong, Chuanxing Luo, Lijing Deng, Yiyun Deng, Xiaoqi Xie, Zhongwei Zhang, Yan Zhou, Xuelian Liao
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  ABSTRACT: We aimed to investigate whether interleukin-10 (IL-10) -1082 G/G genotype is associated with lower mortality of acute respiratory distress syndrome (ARDS) in a Chinese population. A hospital-based case-control study was conducted in 314 cases of ARDS and 210 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for 30-day mortality. The -1082G/G genotype was associated with lower development of ARDS (OR=0.51; 95% CI 0.34-0.76; P=0.001). Among patients with ARDS, the -1082G/G genotype was associated with lower 30-day mortality (OR=0.44; 95% CI 0.25-0.76; P=0.003). In conclusion, IL-10-1082 G/G genotype is associated with lower development and mortality of ARDS in a Chinese population.
  Molecular Biology Reports 01/2012; 39(1):1-4. · 2.93 Impact Factor
• Article: Association of interleukin-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population.

  Xiaodong Jin, Zhi Hu, Yan Kang, Chang Liu, Yongfang Zhou, Xiaodong Wu, Jin Liu, Mingxing Zhong, Chuanxing Luo, Lijing Deng, Yiyun Deng, Xiaoqi Xie, Zhongwei Zhang, Yan Zhou, Xuelian Liao
  [show abstract] [hide abstract]
  ABSTRACT: We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions. IL-10-1082 promoter polymorphisms were analyzed with polymerase chain reaction amplification followed by restriction fragment length polymorphism. Mortality was recorded if it occurred within 30 days from admission. The -1082G/G genotype was associated with lower frequency of ARDS (odds ratios=0.51; 95% confidence intervals: 0.34-0.76; p=0.001), and in patients with ARDS, it was associated with lower mortality within 30 days (odds ratios=0.44; 95% confidence intervals: 0.25-0.76; p=0.003) than in controls. We conclude that IL-10-1082 G/G genotype is associated with a decreased rate development of ARDS and mortality in this Chinese population.
  Genetic Testing and Molecular Biomarkers 12/2010; 15(4):203-6. · 1.11 Impact Factor