Christopher T Dibble

Publications (2)10.5 Total impact

• Article: Brachial Artery Diameter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis-Right Ventricle Study.

  Christopher T Dibble, Daichi Shimbo, R Graham Barr, Emilia Bagiella, Harjit Chahal, Corey E Ventetuolo, David M Herrington, Joao A C Lima, David A Bluemke, Steven M Kawut
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  ABSTRACT: Abstract BACKGROUND:Endothelial dysfunction is associated with left ventricular morphology and long-term cardiovascular outcomes. The purpose of this study was to assess the relationship between both baseline brachial artery diameter and peripheral endothelial function (assessed by brachial artery ultrasound) and right ventricular (RV) mass, RV end-diastolic volume (RVEDV), and RV ejection fraction (RVEF). METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging (MRI) and brachial artery ultrasound on participants without clinical cardiovascular disease. Baseline brachial artery diameter and flow-mediated dilation (FMD) were assessed. RESULTS:The mean age was 60.9 years and 49.4% were male (n=2425). In adjusted models, larger brachial artery diameter was strongly associated with greater RV mass (β = 0.55 g, p < 0.001), larger RVEDV (β = 3.99 mL, p < 0.001), and decreased RVEF (β = -0.46%, p = 0.03). These relationships persisted after further adjustment for the respective left ventricular parameters. FMD was not associated with RV mass or RVEF and was only weakly associated with RVEDV. CONCLUSIONS:Brachial artery diameter is associated with greater RV mass and RVEDV as well as lower RVEF. Changes in the systemic arterial circulation may have pathophysiologic links to pulmonary vascular dysfunction or abnormalities in RV perfusion.
  Chest 05/2012; · 5.25 Impact Factor
• Article: Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study.

  Christopher T Dibble, Joao A C Lima, David A Bluemke, Julio A Chirinos, Harjit Chahal, Michael R Bristow, Richard A Kronmal, R Graham Barr, Victor A Ferrari, Kathleen J Propert, Steven M Kawut
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  ABSTRACT: Dysfunction of the interventricular septum has been implicated in right ventricular (RV) failure. However, little is known about the relationship between ventricular septal and RV function in patients without clinical cardiovascular disease. We hypothesized that better septal function would be associated with higher RV ejection fraction and lower RV mass and volume by cardiac MRI. In the Multi-Ethnic Study of Atherosclerosis (MESA), cardiac MRI was performed on community-based participants without clinical cardiovascular disease. Images were analyzed by the harmonic phase method to measure peak circumferential systolic midventricular strain for each wall (anterior, lateral, inferior, and septal). Multivariable linear regression and generalized additive models were used to assess the relationship between septal strain and RV morphology. There were 917 participants (45.7% women) with a mean age of 65.7 years. Better septal function was associated with higher RV ejection fraction in a nonlinear fashion after adjustment for all covariates (P = .03). There appeared to be a threshold effect for the contribution of septal strain to RV systolic function, with an almost linear decrement in RV ejection fraction with septal strain from -18% to -10%. Septal function was not related to RV mass or volume. Interventricular septal function was linked to RV systolic function independent of other left ventricular regions, even in individuals without clinical cardiovascular disease. This finding confirms animal and human research suggesting the importance of septal function to the right ventricle and implies that changes in septal function could herald RV dysfunction. Trial registry: ClinicalTrials.gov; No.: NCT00005487; URL: www.clinicaltrials.gov.
  Chest 02/2011; 140(2):310-6. · 5.25 Impact Factor