[Show abstract][Hide abstract] ABSTRACT: Root bark of Alangium salvifolium (Linn.f.) Wang. (Family Alangiaceae) is a reputed drug mentioned in the ancient books of Ayurveda and Siddha for the treatment of epilepsy, jaundice, hepatitis etc. Root bark of the plant was subjected to macro-microscopic, photomicrographic, physico-chemical, fluorescence, preliminary phytochemical, TLC and HPTLC to fix quality standards for this drug. Microscopic studies have shown stratified phellem, rhytidome, cluster crystals of calcium oxalate and uni- to triseriate medullary rays in the root bark. Chloroform, ethyl acetate, ethanol extracts and alkaloid fraction revealed characteristic chromatographic patterns with presence of alkaloids in varying concentrations. This study would be useful in the identification and authentication of the raw drug.
[Show abstract][Hide abstract] ABSTRACT: Root of Cocos nucifera Linn. (Arecaceae) is astringent, diuretic, anthelmintic and useful in curing pharyngodynia, uterine disorders, blenorrhagia, bronchitis, hepatopathy, strangury and helminthiasis. It is an important commodity in folklore medicines of south India for urinary troubles. So far there is no record on detailed pharmacognostic evaluation of this crude drug, hence this communication throws light on parameters essential to fix standards for this medicinal material.
[Show abstract][Hide abstract] ABSTRACT: Two flavonoids and two carboxylic acids have been isolated from the ethyl acetate extract of the roots. The structures of these compounds have been established as myricetin-3,3',5',7-tetra methyl ether 1. ampelopsin-3',4',5',7-tetramethyl ether 2, plumbagic acid 3 and roseanoic acid 4 on the basis of UV, IR, H-1 and C-13 NMR and mass spectrum studies. The two carboxylic acids 3 and 4 arc reported here for the first time. Compounds 1 and 2 are the first report from the genus plumbago.
[Show abstract][Hide abstract] ABSTRACT: Physicochemical parameters of roots of three Plumbago species, Plumbago capensis, P. rosea and P. zeylanica belonging to Plumbaginaceae were analyzed. Microbial contamination, aflatoxins, pesticide residue and heavy metal content were also determined. Attempt has also been made to estimate the biologically active chemical plumbagin present in them and the data compared. The study ensures that the quality control parameters do help in the proper standardization of the crude drugs in drug development process for global acceptance.
Indian Journal of Pharmaceutical Sciences 01/2010; 72(1):86-91. DOI:10.4103/0250-474X.62254 · 0.48 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The present communication attempts to evaluate the pharmacognostical and physicochemical parameters of the roots of Plumbago capensis Thunb.; (syn. Plumbago auriculata Lam.) fam. Plumbaginaceae, a sub-scandent shrub with diffuse branches, oblong or oblong-spathulate leaves with pale blue flower. It is indigenous to South Africa and grown in the gardens of India as an ornamental plant. The roots are used as styptic, scrofula, emetic, smeared to remove warts, headache, decoction is used in black water fever. As there is no pharmacognostic work reported on root, the macro-and microscopic characters are carried out and demonstrated along with their physicochemical parameters and fluorescence analysis. The root shows thick walled lignified groups of pericyclic fibres, xylem region and medullary ray cells consists of simple starch grains microscopically. Physicochemical studies revealed, total moisture content (8.11%), total ash (2.62%), acid insoluble ash (0.68%), water-soluble ash (1.89%), alcohol soluble extractive value (9.14%), and water-soluble extractive value (13.18%). Preliminary organic analysis revealed the presence of quinone, flavones, steroid, phenol in difference extracts respectively. These specific identities will be useful in identification of the raw drug in dried form.