Antonio Frizziero

Publications (3)11.09 Total impact

• Article: Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders.

  Antonio Frizziero, Erika Giannotti, Francesco Oliva, Stefano Masiero, Nicola Maffulli
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  ABSTRACT: IntroductionThe therapeutic use of interleukin 1 (IL-1) cytokine receptor antagonists (IL-1RA) has promoted the development of new biological therapies for osteoarthritis (OA). Autologous conditioned serum (ACS) is an alternative, safe and well-tolerated treatment in OA.Sources of dataWe performed a comprehensive search of PubMed, Medline, Cochrane, CINAHL, Embase, SportDiscus, Pedro and Google scholar databases using keywords such as 'interleukin 1', 'osteoarthritis' and 'autologous conditioned serum'.Areas of agreementACS, containing endogenous anti-inflammatory cytokines including IL-1RA and several growth factors, could reduce pain and increase function and mobility in mild to moderate knee OA.Area of controversyGiven the limited data available on the composition of ACS, the mechanisms through which ACS produces clinical improvement, the duration of its effect and the changes in cytokine levels after repeated injections are still unknown.Growing pointsAlthough previous clinical data are encouraging and confirm the safety of this modality, given the limitations of current studies, there should be additional, controlled trials to further confirm efficacy for the use of ACS in OA treatment.Area timely for developing researchACS can lead to enhancement of tissue regeneration and to reduction of degenerative mechanisms.
  British Medical Bulletin 07/2012; · 4.54 Impact Factor
• Source

  Available from: Marina Marini

  Article: Effect of training and sudden detraining on the patellar tendon and its enthesis in rats.

  Antonio Frizziero, Milena Fini, Francesca Salamanna, Arsenio Veicsteinas, Nicola Maffulli, Marina Marini
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  ABSTRACT: Different conditions may alter tendon characteristics. Clinical evidence suggests that tendon injuries are more frequent in athletes that change type, intensity and duration of training. Aim of the study was the assessment of training and especially detraining on the patellar tendon (PT) and its enthesis. 27 male adult Sprague-Dawley rats were divided into 3 groups: 20 rats were trained on a treadmill for 10 weeks. Of these, 10 rats were euthanized immediately after training (trained group), and 10 were caged without exercise for 4 weeks before being euthanized (de-trained group). The remaining 7 rats were used as controls (untrained rats). PT insertion, structure (collagen fiber organization and proteoglycan, PG, content), PT thickness, enthesis area, and subchondral bone volume at the enthesis were measured by histomorphometry and microtomography. Both PG content and collagen fiber organization were significantly lower in untrained and detrained animals than in trained ones (p < 0.05 and p < 0.0001). In the detrained group, fiber organization and PG content were worse than that of the untrained groups and the untrained group showed a significantly higher score than the detrained group (p < 0.05). In the trained group, the PT was significantly thicker than in untrained group (p < 0.05). No significant differences in the enthesis area and subchondral bone volume among the three groups were seen. Moderate exercise exerts a protective effect on the PT structure while sudden discontinuation of physical activity has a negative effect on tendons. The present results suggest that after a period of sudden de-training (such as after an injury) physical activity should be restarted with caution and with appropriate rehabilitation programs.
  BMC Musculoskeletal Disorders 01/2011; 12:20. · 1.58 Impact Factor
• Article: Surgical approaches in osteoarthritis: role of arthroscopy.

  Luigi Frizziero, Massimo Reta, Fedele Rizzuti, Fabio Zizzi, Antonio Frizziero, Andrea Facchini
  Seminars in Arthritis and Rheumatism 07/2005; 34(6 Suppl 2):53-7. · 4.97 Impact Factor