C Triginer

Publications (12)37.39 Total impact

• Article: [The use of aminoglucosides in critical patients].

  J Rello, C Triginer
  Medicina Clínica 04/1992; 98(9):355-6. · 1.38 Impact Factor
• Article: Changes in gentamicin pharmacokinetic profiles induced by mechanical ventilation.

  C Triginer, I Izquierdo, R Fernández, J Torrent, S Benito, A Net, F Jane
  [show abstract] [hide abstract]
  ABSTRACT: The influence of controlled mechanical ventilation (CMV) on the pharmacokinetic profile of gentamicin has been examined in 23 patients after elective open heart surgery. A parallel design was adopted in two groups of patients; 13 patients requiring CMV for at least 32 h after surgery, all of whom were able to breath spontaneously (SB) after 72 h (study group), and 10 patients who required CMV for only a brief period and who showed SB at 32 h postsurgery. Haemodynamic parameters remained stable throughout the study. Apparent volume of distribution (VZ), half-life (t1/2), total clearance (CL), peak (Cmax") and trough (Cmin") plasma levels at steady-state for target levels (6-8 microgram/ml), were measured. In the study group significant differences between CMV and SB conditions were found in VZ (mean 0.36 and 0.25 l/kg). t1/2 (mean 3.63 and 2.90 h) and Cmax" (mean 4.30 and 5.53 microgram/ml) while Cmin" (mean 1.06 microgram.ml-1 and 0.92 microgram.ml-1) did not change significantly. In contrast, the pharmacokinetics in the control group showed no differences. It appears that CMV leads to an increase in gentamicin Vz which accounts for the fall in Cmax" below the therapeutic dose range (less than 5 microgram/ml) recommended for gentamicin. It seems advisable to use a large dose of gentamicin in patients receiving CMV, even before the level is assessed.
  European Journal of Clinical Pharmacology 02/1991; 40(3):297-302. · 2.85 Impact Factor
• Article: Theophylline plasma concentrations and silicone central venous catheter: a potential source of error.

  C Triginer, J Rello, J M Sánchez, A Net
  DICP: the annals of pharmacotherapy 04/1990; 24(3):324.
• Article: Gentamicin volume of distribution in critically ill septic patients.

  C Triginer, I Izquierdo, R Fernández, J Rello, J Torrent, S Benito, A Net
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  ABSTRACT: Gentamicin intrapatient pharmacokinetics variations were studied in 40 critically ill medical patients, suffering gram-negative sepsis. These patients were studied in two phases throughout gentamicin treatment: firstly, on the second day of treatment, when aggressive fluid therapy was required, and secondly, five days later, when patients had achieved a more stable clinical condition. Pharmacokinetic parameters were determined using least squares linear regression analysis assuming a one-compartment model using the Sawchuk-Zaske method. The apparent volume of distribution (Vd) in the first phase of the study was 0.43 +/- 0.12 L/kg, while on the seventh day of treatment it was 0.29 +/- 0.17 L/kg (p less than 0.001). Statistically significant differences were also observed for peak serum concentration (p less than 0.001), total dosage recommended (p less than 0.001) and half-life (p less than 0.05), whilst differences were not found for trough levels. From the analysis of the results obtained, we recommend increasing the initial dosage and monitoring plasma levels within the first days of therapy in critically ill patients treated with gentamicin, since important variations in aminoglycoside Vd related to disease, fluid balance and renal function, commonly occur in these patients.
  Intensive Care Medicine 02/1990; 16(5):303-6. · 5.40 Impact Factor
• Article: Gentamicin pharmacokinetic changes related to mechanical ventilation.

  C Triginer, R Fernández, I Izquierdo, J Rello, S Benito
  DICP: the annals of pharmacotherapy 12/1989; 23(11):923-4.
• Article: [Nosocomial infection control programs at intensive care units].

  J Rello, E Quintana, C Triginer, A Net
  Medicina Clínica 12/1989; 93(16):637-8. · 1.38 Impact Factor
• Article: False hypoxemia induced by leukocytosis.

  J Rello, S Benito, C Triginer, A Net
  Critical Care Medicine 10/1989; 17(9):970. · 6.33 Impact Factor
• Article: [Malignant nongranulomatous pulmonary hypertension in a patient addicted to parenteral drugs].

  C Triginer, R Fernández, M Alejo, A Net
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  ABSTRACT: We report the first case in the Spanish literature of pulmonary hypertension (PHT) caused by vascular sclerosis in a parenteral drug abuser female. The clinical diagnosis of PHT was confirmed in the necropsy study, which ruled out granulomas and discovered only vascular sclerosis and hypertrophy as causative factors of the clinical picture. The different etiological and pathogenetical mechanisms reported in the literature as causing PHT in this type of patients are reviewed.
  Medicina Clínica 04/1989; 92(11):418-20. · 1.38 Impact Factor
• Article: [Dermatomyositis and hypernephroma].

  C Triginer, R Fernández, J M Sánchez, A Net
  Revista Clínica Española 03/1989; 184(2):110. · 2.01 Impact Factor
• Article: Acute renal failure following massive mannitol infusion.

  J Rello, C Triginer, J M Sánchez, A Net
  Nephron 02/1989; 53(4):377-8. · 13.26 Impact Factor
• Article: [Atrioventricular block in septic shock].

  R Fernández, C Triginer, A Net
  Medicina Clínica 11/1988; 91(14):544-5. · 1.38 Impact Factor
• Article: [Spontaneous hematoma of the sheath of the rectus muscle in a patient treated with cefotaxime].

  C Triginer, J Gumá, R Fernández, A Net
  Revista Clínica Española 05/1988; 182(6):341-2. · 2.01 Impact Factor