ABSTRACT: Objective: The aim of our study was to investigate the oxidative and antioxidative status of plasma and plasma prolidase enzyme activity on gallstone disease. Material and Methods: The study group included 35 patient with gallstone disease and 30 healthy volunteers as control subjects. Plasma prolidase activity and oxidative-antioxidative parameters were measured. Antioxidative status of plasma was evaluated by measuring total antioxidant capacity. To determine oxidative status; total oxidant status and oxidative stress index were deermied. Results: Total antioxidant capacity levels of plasma were lower in the patients with gallstone disease than in controls (p<0.001). In contrast, total oxidant status levels and oxidative stress index values were higher in the patients than in controls (p<0.05 and p<0.001, respectively). Beside these, plasma prolidase activity was significantly lower in the patients than controls (p<0.001). Conclusions: The present results indicated that the oxidant parameters increased and antioxidant parameters decreased in patients with gallstones, and that these patients were exposed to oxidative stress.
Trakya Universitesi Tip Fakultesi Dergisi. 01/2010;