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ABSTRACT: The Objective of this paper is to evaluate novel method for analyzing the nonlinear correlation of the uterine electromyography (EMG). The application of this method may improve monitoring in pregnancy, labor detection and preterm labor detection. Uterine EMG signals recorded from a 4x4 matrix of electrodes on the subjects' abdomen are used here. The propagation was analyzed using the nonlinear correlation coefficient (h2). Signals from 49 women (36 during pregnancy and 13 in labor) at different gestational age were used. ROC curves were computed to evaluate the potential of three methods to differentiate between 174 contractions recorded during pregnancy and 115 contractions recorded during labor. The results indicate considerably better performance of the nonlinear correlation analysis (Area Under Curve=0.85) when compared to classical frequency parameters (Area Under Curve= 0.76 and 0.66) in distinguishing labor contractions from normal pregnancy contractions. We conclude that the analysis of the propagation of the uterine electrical activity using the nonlinear correlation coefficient (h2) is a promising way of improving the usefulness of uterine EMG signals for clinical purposes, such as monitoring in pregnancy, labor detection and prediction of preterm labor.
IEEE transactions on bio-medical engineering 11/2012; · 2.15 Impact Factor
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ABSTRACT: Most of the studies on the synchronization between EHG signals, recorded during the same contractions at different locations, are limited to the use of only two channels. Multichannel techniques have however been widely applied to EEG signals but rarely to EHG. In this paper, we investigate the use of multichannel uterine EMG signals for classifying contractions. We compare the performance of phase synchronization in distinguishing between labor and normal pregnancy contractions by using either only two channels or a 4×4 matrix positioned on the woman's abdomen. We used two indexes to measure the phase synchronization: mean phase coherence and phase entropy. ROC curves indicate that the use of multichannel signals can significantly improve the classification rate of pregnancy and labor contractions.
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE; 10/2010
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ABSTRACT: The analysis of the electrical activity of the uterus recorded externally, the electrohysterogram (EHG), may find an application in the prediction of labor. In the literature parameters that are supposed to be related to the excitability of the uterine cells have almost exclusively been used for this purpose. In the present paper we evaluate the possible use of synchronization parameters for EHG measured in several places on the uterus for this prediction. The EHG is mainly composed of two frequency components called FWL and FWH. These components may be related to the synchronization and the excitability phenomenon respectively. In order to study independently these frequency components, we extracted the corresponding ridges of the wavelet transform of the EHG using the GVF-snake method. For each frequency component we computed parameters that are related to the frequency content of the signals and parameters that consider the synchronization relationship between signals. The synchronization parameters used were the mean phase coherence and the phase entropy. The values of the different parameters were compared during pregnancy and labor by statistical analysis. The detection quality of each parameter was evaluated using ROC curves. Our results suggest that synchronization parameters could be used for the detection of labor in addition to the classical previously published parameters. Another important result of our study is that both FWH and FWL seem related to excitability but only FWL seems to be related to the synchronization of the uterus at term.
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE; 10/2010
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ABSTRACT: Labor prediction using the electrohysterogram has immediate clinical applications and has been the aim of several studies in recent years. Studies using various linear methods such as classic spectral analysis do not give clinically useful results. In this paper we present the use of two methods that investigate nonlinearity to predict normal labor. We show the comparison between a linear method that is known from the literature (mean power frequency) and two nonlinear methods (approximate entropy and time reversibility) using ROC analysis. The comparison indicates that the best method for pretreatment to classify pregnancy and labor signals is time reversibility. The results indicate that time reversibility is a very promising tool for distinguishing between labor and physiological contractions during pregnancy. This could be the first step in developing a clinical application method to predict preterm labor.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2010; 2010:2387-90.
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[show abstract]
[hide abstract]
ABSTRACT: Most of the studies on the synchronization between EHG signals, recorded during the same contractions at different locations, are limited to the use of only two channels. Multichannel techniques have however been widely applied to EEG signals but rarely to EHG. In this paper, we investigate the use of multichannel uterine EMG signals for classifying contractions. We compare the performance of phase synchronization in distinguishing between labor and normal pregnancy contractions by using either only two channels or a 4x4 matrix positioned on the woman's abdomen. We used two indexes to measure the phase synchronization: mean phase coherence and phase entropy. ROC curves indicate that the use of multichannel signals can significantly improve the classification rate of pregnancy and labor contractions.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2010; 2010:4642-5.
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[show abstract]
[hide abstract]
ABSTRACT: The analysis of the electrical activity of the uterus recorded externally, the electrohysterogram (EHG), may find an application in the prediction of labor. In the literature parameters that are supposed to be related to the excitability of the uterine cells have almost exclusively been used for this purpose. In the present paper we evaluate the possible use of synchronization parameters for EHG measured in several places on the uterus for this prediction. The EHG is mainly composed of two frequency components called FWL and FWH. These components may be related to the synchronization and the excitability phenomenon respectively. In order to study independently these frequency components, we extracted the corresponding ridges of the wavelet transform of the EHG using the GVF-snake method. For each frequency component we computed parameters that are related to the frequency content of the signals and parameters that consider the synchronization relationship between signals. The synchronization parameters used were the mean phase coherence and the phase entropy. The values of the different parameters were compared during pregnancy and labor by statistical analysis. The detection quality of each parameter was evaluated using ROC curves. Our results suggest that synchronization parameters could be used for the detection of labor in addition to the classical previously published parameters. Another important result of our study is that both FWH and FWL seem related to excitability but only FWL seems to be related to the synchronization of the uterus at term.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2010; 2010:17-20.
