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M G Kim,
J Lamsal,
T W Heitmann,
G S Tucker,
D K Pratt,
S N Khan,
Y B Lee, A Alam,
A Thaler,
N Ni,
S Ran,
S L Bud'ko,
K J Marty,
M D Lumsden,
P C Canfield,
B N Harmon,
D D Johnson,
A Kreyssig,
R J McQueeney,
A I Goldman
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[hide abstract]
ABSTRACT: The spin fluctuation spectra from nonsuperconducting Cu-substituted, and superconducting Co-substituted, BaFe_{2}As_{2} are compared quantitatively by inelastic neutron scattering measurements and are found to be indistinguishable. Whereas diffraction studies show the appearance of incommensurate spin-density wave order in Co and Ni substituted samples, the magnetic phase diagram for Cu substitution does not display incommensurate order, demonstrating that simple electron counting based on rigid-band concepts is invalid. These results, supported by theoretical calculations, suggest that substitutional impurity effects in the Fe plane play a significant role in controlling magnetism and the appearance of superconductivity, with Cu distinguished by enhanced impurity scattering and split-band behavior.
Physical Review Letters 10/2012; 109(16):167003. · 7.37 Impact Factor
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M. G. Kim,
J. Lamsal,
T. W. Heitmann,
G. S. Tucker,
D. K. Pratt,
S. N. Khan,
Y. B. Lee, A. Alam,
A. Thaler,
N. Ni,
S. Ran,
S. L. Bud'ko,
K. J. Marty,
M. D. Lumsden,
P. C. Canfield,
B. N. Harmon,
D. D. Johnson,
A. Kreyssig,
R. J. McQueeney,
A. I. Goldman
[show abstract]
[hide abstract]
ABSTRACT: The spin fluctuation spectra from nonsuperconducting Cu-substituted, and
superconducting Co-substituted, BaFe2As2 are compared quantitatively by
inelastic neutron scattering measurements and are found to be indis-
tinguishable. Whereas diffraction studies show the appearance of incommensurate
spin-density wave order in Co and Ni substituted samples, the magnetic phase
diagram for Cu substitution does not display incommensu- rate order,
demonstrating that simple electron counting based on rigid-band concepts is
invalid. These results, supported by theoretical calculations, suggest that
substitutional impurity effects in the Fe plane play a signifi- cant role in
controlling magnetism and the appearance of superconductivity, with Cu
distinguished by enhanced impurity scattering and split-band behavior.
04/2012;
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Y Luo,
H Zhou,
L Liu,
T Shen,
W Chen,
B Xu,
X Han,
F Zhang,
R S Scott,
J S Alexander, A Alam,
S Huang
[show abstract]
[hide abstract]
ABSTRACT: Ciclopirox olamine (CPX), an off-patent antifungal agent used to treat mycoses of skin and nails, has recently been demonstrated to be a potential anticancer agent. However, the underlying mechanism is not well understood. Here, for the first time, we show that CPX inhibited lymphangiogenesis in an in vitro model (tube formation). This effect was, in part, associated with inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) expression, as overexpression of VEGFR-3 conferred partial resistance to CPX inhibitory effect on tube formation in lymphatic endothelial cells (LECs), whereas downregulation of VEGFR-3 mimicked the effect of CPX, blocking the tube formation. Further study revealed that CPX did not alter mRNA level, but inhibited protein synthesis and promoted protein degradation of VEGFR-3. In addition, we found that CPX inhibited phosphorylation of the extracellular signal-related kinase 1/2 (ERK1/2), a downstream effector of VEGFR-3. Overexpression of VEGFR-3 attenuated CPX inhibition of ERK1/2 phosphorylation, whereas downregulation of VEGFR-3 inhibited ERK1/2 phosphorylation in LECs. Ectopic expression of constitutively active mitogen-activated protein kinase kinase 1 (MKK1) resulted in activation of ERK1/2 and partially prevented CPX inhibition of LEC tube formation. The results suggest that CPX inhibits LEC tube formation at least, in part, through inhibiting VEGFR-3-mediated ERK signaling pathway.
Oncogene 01/2011; 30(18):2098-107. · 6.37 Impact Factor
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Environment International 01/2008; 34((7)):p1062-1071. · 5.30 Impact Factor
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[show abstract]
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ABSTRACT: Organochlorine pesticides (OCPs) are an important potential component of chemical pollutants used extensively for agriculture and sanitation purposes in India as these are comparatively cheap and effective. These persistent organic compounds such as HCH isomers, DDT and its metabolites are the predominant chemical contaminants found along the Indian coast and thus constitute both alluring and grave areas of scientific research. Our objective in the paper is to provide a comprehensive account of the distribution of organochlorine pesticides in biotic and abiotic compartments of the Indian coastal environment, make some comments on their environmental sources, their movement through the food chain and possible ecotoxicological risk of health in biota including humans.The prevalent HCH, DDT and HCB concentrations differ markedly in eastern and western coast of India reflecting differing agricultural and other usage and their ultimate input into the coastal environment by several rivers and the bioturbation activities of macrozoobenthos (bivalve mollusks, polychaetous annelids, etc.). In several cases, the DDT levels exceeded the effects range-low (ER-L) and could thus cause acute biological impairments, in comparison with the sediment quality guidelines. Contributions of DDT metabolites (DDT, DDD and DDE residues) vary in different Indian coastal regions predominated by pp′-DDT and pp′-DDD. Measured concentrations of HCHs were lower than DDTs that might be due to higher water solubility, vapor pressure and biodegradability of the latter. HCH and DDT residues in fish in India were lower than those in the temperate countries indicating a lower accumulation in tropical fish, which might be related to rapid volatilization of this insecticide in the tropical environment. The concentrations of other chlorinated pesticides (aldrin, dieldrin, eldrin, methoxychlor, endosulfan sulphate) were lower and not generally of great concern.
Environment International.
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ABSTRACT: The modulating effect of spearmint (Mentha spicata) on benzoyl peroxide-induced responses of tumor promotion in murine skin was investigated. Benzoyl peroxide (BPO) is an effective cutaneous tumor promoter acting through the generation of oxidative stress, induction of ornithine decarboxylase activity and by enhancing DNA synthesis. BPO treatment (20 mg/animal) increased cutaneous microsomal lipid peroxidation and hydrogen peroxide generation. The activity of cutaneous antioxidant enzymes, namely catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase, was decreased and the level of cutaneous glutathione was depleted. BPO treatment also induced the ornithine decarboxylase activity and enhanced the [3H]thymidine uptake in DNA synthesis in murine skin. Prophylactic treatment of mice with spearmint extract (10, 15 and 20 mg/kg) 1 hr before BPO treatment resulted in the diminution of BPO-mediated damage. The susceptibility of cutaneous microsomal membrane to lipid peroxidation and hydrogen peroxide generation was significantly reduced (P <0.05 ). In addition, depleted levels of glutathione, inhibited activity of glutathione dependent and antioxidant enzymes were recovered to a significant level (P <0.01, P <0.05 and P <0.01, respectively). Similarly, the elevated ornithine decarboxylase activity and enhanced thymidine uptake in DNA synthesis was inhibited significantly (P <0.05 ) in a dose-dependent manner. The protective effect of spearmint was dose dependent in all parameters. The result suggests that spearmint is an effective chemopreventive agent that may suppress BPO-induced cutaneous oxidative stress, toxicity and hyperproliferative effects in the skin of mice.
Food and Chemical Toxicology.
