A. Dolabela de Lima

Max Planck Institute for Brain Research, Frankfurt, Hesse, Germany

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Publications (2)4.88 Total impact

  • C.C. Stichel · A. Dolabela de Lima · W. Singer ·
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    ABSTRACT: The goal of this study was to determine whether cat striate cortex contains neurons with choline acetyltransferase-like immunoreactivity. Two different monoclonal antibodies were applied with various fixation protocols. As controls served selected regions of the cat brain and the rat neocortex where cholinergic neurons had been demonstrated previously with independent methods. All experimental protocols labelled the presumptive cholinergic neurons in the central regions but revealed only a few weakly stained neurons in cat striate cortex. These had a non-pyramidal morphology and were scattered throughout all layers.
    Brain Research 04/1987; 405(2-405):395-399. DOI:10.1016/0006-8993(87)90313-1 · 2.84 Impact Factor
  • A. Dolabela de Lima · V M Montero · W Singer ·
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    ABSTRACT: In this study we demonstrate at the ultrastructural level that both the dorsal lateral geniculate nucleus (dLGN), the visual relay of the thalamus, and the perigeniculate nucleus (PGN), the visual segment of the thalamic reticular nucleus (TRN), are densely innervated by fibres with Choline-Acetyl-Transferase (ChAT) like immunoreactivity. These axons make synaptic contacts with interneurones considered to be inhibitory, both in the PGN and within the synaptic glomeruli of the dLGN. In addition, Chat positive terminals form intra- and extraglomerular synapses with dendrites thought to arise from relay cells. We interpret these results as evidence for direct cholinergic modulation of both relay cells and inhibitory interneurones.
    Experimental Brain Research 02/1985; 59(1):206-12. DOI:10.1007/BF00237681 · 2.04 Impact Factor