O.O. Adebawo

Publications (7)8.53 Total impact

• Article: Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract.

  E O Ajani, A A Salako, P D Sharlie, W A Akinleye, A O Adeoye, B A Salau, O O Adebawo
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  ABSTRACT: Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) is being widely used in Western Nigeria in treating various symptoms of ophthalmic diseases; however scientific data in support of this medicinal use have not been reported. This study, investigated the efficacy of Hydrocotyl bonariensis leave extract in offering protection against experimental cataract and also examined its remediation effect when administered after cataract onset. Weanling albino rats fed with 30% galactose diet were used in the study. Mechanisms of action of the extract were investigated by measuring the degree of lens peroxidation, lens antioxidant status and lens protein concentration. Severity of cataract was determined by measuring the cataract index. The extract at 500 mg kg(-1) reduced cataract index significantly and also reduced cataract progression when administered after cataract onset. Administration of this dosage also significantly reduced the degree of lens peroxidation, increased the level of reduced glutathione (GSH) and the lens catalase and superoxide dismutase activity. The extract also prevents protein insolubilization. Administration of the extract at 1000 mg kg(-1) reduced cataract index and lens peroxidation but did not increase the antioxidant status significantly. Administration of the extract after cataract onset reduced cataract index, moderately increased percentage soluble protein above the value prior to the arrest of hypergalactosemia but did not increase the antioxidant status. Our study suggests that Hydrocotyl bonariensis protects against galactose-induced cataract, and that administration of the extract after cataract onset reduced cataract progression but did not reverse cataractogenesis.
  Journal of ethnopharmacology 06/2009; 123(1):134-42. · 2.32 Impact Factor
• Article: Utilization of high lysine-producing strains of Lactobacillus plantarum as starter culture for nutritional improvement of ogi

  O.O. Adebawo, J.O. Akingbala, J.L. Ruiz-Barba, O. Osilesi
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  ABSTRACT: A high lysine-producing mutant of Lactobacillus plantarum (OG 261-5) derived from a wild type strain (OG 261) previously isolated from fermenting ogi was evaluated for nutritional improvement of ogi in a modified fermentation process. Results indicate that ogi obtained by fermentation with the pure culture of the mutant compared to traditional ogi increased in concentration of available lysine from 228.5 12.0 mg/100 g to 525.1 25.8 mg/100 g, tryptophan from 58.6 8.0 mg/100 g to 114.3 11.0 mg/100 g and tyrosine from 408.5 13.7 mg/100 g to 4636.5 11.3 mg/100 g. However, the contents of valine, leucine, isoleucine and phenylalanine were substantially reduced which may affect the protein quality of the modified ogi. The modified process shortened the period of traditional ogi production from five days to one by reducing the two-stage fermentation (i.e. soaking and souring stages) to a one-stage process and the total protein recovery was better compared to traditional ogi processing. There was no significant difference (P > 0.05) in organoleptic quality attributes of colour, flavour, and overall acceptability of ogi produced by the modified process and the traditional ogi.
  World Journal of Microbiology and Biotechnology 06/2000; 16(5):451-455. · 1.53 Impact Factor
• Source

  Available from: Gbekeloluwa B. Oguntimein

  Article: Regulation of aspartokinase in Lactobacillus plantarum.

  O O Adebawo, J L Ruiz-Barba, P J Warner, G B Oguntimein
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  ABSTRACT: As a rational approach to the genetic development of a stable lysine overproducing strain of Lactobacillus plantarum for the fermentation of 'ogi', a Nigerian fermented cereal porridge, regulation of lysine biosynthesis in this species was investigated. Spontaneous lysine overproducing mutants of Lact. plantarum were obtained and their aspartokinase activities compared with those of wild-type strains under different conditions. Results showed that aspartokinase activity of Lact. plantarum cell extracts was not inhibited by either lysine, threonine, methionine or combinations of lysine and threonine. Instead, methionine enhanced aspartokinase activity in vitro. Results indicated that lysine biosynthesis in Lact. plantarum could be regulated by lysine via the control of aspartokinase production in a way different to that described for other bacteria.
  Journal of Applied Microbiology 03/1997; 82(2):191-6. · 2.34 Impact Factor
• Article: Regulation of aspartokinase in Lactobacillus plantarum

  O.O. Adebawo, J.L. Ruiz-Barba, P.J. Warner, G.B.O. Oguntimein
  [show abstract] [hide abstract]
  ABSTRACT: As a rational approach to the genetic development of a stable lysine overproducing strain of Lactobacillus plantarum for the fermentation of ‘ogi’, a Nigerian fermented cereal porridge, regulation of lysine biosynthesis in this species was investigated. Spontaneous lysine overproducing mutants of Lact. plantarum were obtained and their aspartokinase activities compared with those of wild-type strains under different conditions. Results showed that aspartokinase activity of Lact. plantarum cell extracts was not inhibited by either lysine, threonine, methionine or combinations of lysine and threonine. Instead, methionine enhanced aspartokinase activity in vitro. Results indicated that lysine biosynthesis in Lact. plantarum could be regulated by lysine via the control of aspartokinase production in a way different to that described for other bacteria.
  Journal of Applied Microbiology 01/1997; 82(2):191 - 196. · 2.34 Impact Factor
• Article: Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract

  E.O. Ajani, A.A. Salako, P.D. Sharlie, W.A. Akinleye, A.O. Adeoye, B.A. Salau, O.O. Adebawo
  [show abstract] [hide abstract]
  ABSTRACT: Ethnopharmacological relevanceHydrocotyl bonariensis Comm. Ex Lam (Apiaceae) is being widely used in Western Nigeria in treating various symptoms of ophthalmic diseases; however scientific data in support of this medicinal use have not been reported.Aim of the studyThis study, investigated the efficacy of Hydrocotyl bonariensis leave extract in offering protection against experimental cataract and also examined its remediation effect when administered after cataract onset.Materials and methodsWeanling albino rats fed with 30% galactose diet were used in the study. Mechanisms of action of the extract were investigated by measuring the degree of lens peroxidation, lens antioxidant status and lens protein concentration. Severity of cataract was determined by measuring the cataract index.ResultsThe extract at 500 mg kg−1 reduced cataract index significantly and also reduced cataract progression when administered after cataract onset. Administration of this dosage also significantly reduced the degree of lens peroxidation, increased the level of reduced glutathione (GSH) and the lens catalase and superoxide dismutase activity. The extract also prevents protein insolubilization. Administration of the extract at 1000 mg kg−1 reduced cataract index and lens peroxidation but did not increase the antioxidant status significantly. Administration of the extract after cataract onset reduced cataract index, moderately increased percentage soluble protein above the value prior to the arrest of hypergalactosemia but did not increase the antioxidant status.ConclusionOur study suggests that Hydrocotyl bonariensis protects against galactose-induced cataract, and that administration of the extract after cataract onset reduced cataract progression but did not reverse cataractogenesis.
  Journal of Ethnopharmacology.
• Article: FRUITS AND VEGETABLES MODERATE BLOOD PRESSURE, FIBRINOGEN CONCENTRATION AND PLASMA VISCOSITY IN NIGERIAN HYPERTENSIVES

  O.O. Adebawo, B A Salau, M.M. Adeyanju, A A Famodu, O Osilesi
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  ABSTRACT: Fruits and vegetables contain vital components such as potassium, antioxidants, vitamins and folic acid that might contribute to lowering blood pressure which is a major risk factor in cardiovascular disorders. However, the results of the few investigations on the correlation between intake of fruits and vegetables and cardiovascular disease have been inconsistent. Worse still, there is dearth of information on disease prevention with fruits and vegetables in Africans. Thus, we investigated the relative effect of fruits and vegetables on blood pressure, viscosity of blood and fibrinogen level. Ten weeks intervention study with ≥ 3 times daily consumption of fruits and vegetables by hypertensive patients was conducted. The fruits and vegetables included in the test diet were oranges, banana, pawpaw, mango, pineapple, grape, tangerine, garden egg, okra, pumpkin leaf, spinach, amaranthus and water leaf. The patients were allowed to consume the food servings while their eating habit was not restricted. Blood pressure, blood viscosity and plasma fibrinogen and nutrient intake were determined before and during intervention. The complementary fruits and vegetables included in the normal dietary regimen of the patients during the 10 weeks study increased the levels of potassium, calcium, phosphorus, antioxidants and dietary fiber significantly compared to the baseline values (P<0.01). The systolic and diastolic blood pressure were significantly lowered; percentage differences of -9.01 and -3.73 (P<0.01) respectively were observed after 10 weeks. Percentage differences of -6.02, -38.86 and -5.29 (P<0.05.) were observed for haematocrit, blood viscosity and plasma fibrinogen respectively compared with the base line. Fruits and vegetables lowered the systolic and diastolic blood pressure, blood viscosity and plasma fibrinogen. The decrease in haematocrit and fibrinogen could influence reduction in blood viscosity thereby preventing premature CVD in hypertensive. Daily intake of fresh fruit and vegetable might be beneficial for the prevention and as therapeutic regime for cardiovascular complications.
  African Journal of Food, Agriculture, Nutrition and Development (ISSN: 1684-5358) Vol 7 Num 6.
• Article: Effects Of Fruits And Vegetables On Electrolytes And Blood Pressure Of Hypertensive Patients Seen In Nigeria

  E.S. Idogun, A A Famodu, L.A. Olasunkanmi, O Osilesi, O.O. Adebawo
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  ABSTRACT: High-fruit and high-vegetable diets are known to have ameliorating effects on many diseases and their complications. The objective of this study was to assess the effects of high fruit and high vegetable diets on the electrolytes and blood pressure of hypertensive patients. This experimental study was conducted at Olabisi Onabanjo University Teaching Hospital (formerly Ogun State University), Ogun state, Nigeria. Twenty five hypertensive volunteers from among hypertensive clinic attendees were recruited into the study. They were taught how to prepare two serves of vegetables and fruit (approximately 500g diced fruit salad) per day and were encouraged to consume the serves on daily basis from week one through to week ten. Baseline and bi-weekly assessment of plasma electrolytes, such as sodium, potassium, chloride and bicarbonate was carried out on the patients. Anthropometric measurements and blood pressure were also assessed biweekly on the patients during their routine clinic attendance. There was a gradual reduction in plasma sodium and chloride concentrations as well as the blood pressure which became significant in week ten. The mean baseline plasma sodium reduced significantly from 139.0 ± 0.9mmo/L to 137.5 ± 0.9mml/L, P > 0.001 after ten weeks of high fruit and high vegetable diets. Plasma chloride also reduced from baseline value of 103.2 ± 2.5mmol/L to 98.8 ± 0.7mmol/L, P > 0.0001. But the plasma potassium improved from 3.64 ± 0.2mmol/L at baseline to 3.9 ± 0.4mmol/L at week ten, P = 0.0357. The mean systolic blood pressure also dropped from the baseline value of 155.3± 7.6mmHg to 141 ± 2.4 mmHg, P > 0.0001. Also reduced was the mean diastolic blood pressure from 89.3 ± 7.6mmHg to 88.0 ± 2.4, at week ten. However, the plasma bicarbonate and BMI did not charge significantly throughout the study period. High-fruit and high-vegetable diets appear to have an ameliorating effect on the blood pressure of hypertensive patients. This may be beneficial and complementary in the management of hypertension.
  African Journal of Food, Agriculture, Nutrition and Development (ISSN: 1684-5358) Vol 8 Num 3.