Zoran Hajduković

Military Medical Academy, Beograd, Central Serbia, Serbia

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Publications (6)1.96 Total impact

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    ABSTRACT: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. The Salivary IL-8 level was statistically significantly (p < 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p > 0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found. An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.
    The Journal of clinical pediatric dentistry 01/2013; 37(4):377-80. · 0.34 Impact Factor
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    ABSTRACT: The common carotid artery intima-media thickness (CCAIMT) is an independent predictor of cardiovascular events and diabetes mellitus in apparently healthy men. The relationship between features of metabolic syndrome (MS) and CCAIMT is not fully understood. We conducted this study to assess the cross-sectional relationship between CCAIMT and MS parameters in military pilots during their regular annual medical physical examinations. There were 179 pilots (ages 39.69 +/- 5.56 yr) free of cardiovascular disease and diabetes mellitus included in our study. MS was defined according to the International Diabetes Federation criteria. The CCAIMT was measured in the posterior wall of both common carotid arteries within 1 cm proximal to the carotid bulbus, by high-resolution B-mode ultrasonography. We identified MS in 51 (28.5%) and CCAIMT > or = 0.9 mm in 72.1% of subjects, and found the means of CCAIMT in subjects grouped according to the absence and presence of 3, 4, and 5 MS features to be 0.98, 1.05, 1.14, and 1.18 mm respectively, with statistically significant differences between those without and those with 4 and 5 components, as well as between those with MS and those with 5 MS features. A simple logistic regression analyses showed that HDL-c, triglycerides, triglycerides/HDL-c, pulse pressure, and smoking were not associated with CCAIMT > or = 0.9 mm, while multiple logistic regression analysis indicated that total cholesterol and body mass index were independent predictors of CCAIMT. The increase in MS features in our study group correlated with the increase in CCAIMT and total cholesterol and body mass index were identified as the independent predictors of CCAIMT.
    Aviation Space and Environmental Medicine 06/2011; 82(6):622-6. · 0.78 Impact Factor
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    ABSTRACT: Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP) and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pilots as representatives of healthy men. We studied 161 military pilots (age 38 +/- 6 years) free of cardiovascular disease and diabetes mellitus. Traditional and metabolic risk factors were determined. Plasma CRP was measured by immunonephelometry. The common carotid artery intima-media thickness was measured by ultrasonography in the posterior wall of both common carotid arteries. A total of 66.5% subjects had common carotid artery intima-media thickness > 0.9 mm (p < 0.01). The mean CRP plasma concentration was significantly higher in the subjects with common carotid artery intima-media thickness > 0.9 mm than in those with common carotid artery intima-media thickness < or = 0.9 mm. In a simple regression analysis age adjusted CRP was associated with common carotid artery intima-media thickness (beta = 0.285, p < 0.01), and only high density lipoprotein cholesterol was not associated with common carotid artery intima-media thickness. The association between CRP and common carotid artery intima-media thickness remained highly significant after controlling for body mass index, blood pressure, total cholesterol, low density lipoprotein cholesterol, triglycerides, glycosylated hemoglobin and smoking (p < 0.01). Controlling for glucose, triglycerides to high density lipoprotein cholesterol ratio, and total cholesterol to high density lipoprotein cholesterol ratio resulted in some reduction in the strength of the association, but including waist circumference in the regression made the relationship no longer significant (p = 0.119). Body mass index (beta = 0.352; p < 0.01), total cholesterol to high density lipoprotein cholesterol ratio (beta = 0.334; p < 0.01) and age (beta = 0.190; p = 0.036) were the independent predictors of common carotid artery intima-media thickness. In the studied group of healthy men CRP per se is not an independent predictor of early arteriosclerosis, and may mediate the effect of certain traditional risk factors, especially visceral obesity, on promoting aterogenesis.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 07/2009; 66(6):465-71. · 0.21 Impact Factor
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    ABSTRACT: Insulin resistance is related to accelerated atherosclerosis, whereas weight loss is associated with the increasing insulin sensitivity, the improvement of functional and the morphological parameters of arterial circulation, and the reduction of cardiovascular morbidity and mortality. The aim of our study was to evaluate the influence of orlistat treatment on serum insulin level and functional and morphologic parameters of peripheral arterial circulation. We conducted a prospective, randomized, double - blind, placebo - controlled study. Thirty patients with body mass index over 30 kg/m2 normotensive, nonsmokers, without clinically manifested cardiovascular disease or diabetes were randomly assigned either orlistat (120 mg, 3 times daily; n = 20) or placebo (n = 10) in a double - blind manner. All of the patients were on individually calculated hypocaloric diet. The follow-up period was 24 weeks. Arterial pressure, fasting serum glucose and insulin level, triglycerides, total cholesterol and low density lipoprotein-cholesterol were determined at the beginning, following 3 and 6 months. Also, the intima - media thickness of right superficial femoral artery and the mean blood flow velocity were determined with ultrasonography. Inside the period of 3 and 6 months, there were the greater reductions of body mass index, arterial pressure, fasting glucose and insulin level, total cholesterol, low density lipoproteins, as well as the greater reductions of mean velocity blood flow and peripheral pulse pressure in the orlistat group vs the placebo group (p < 0.01). Greater reductions in the waist circumference and intima - media thickness were registered following 6 months in the orlistat vs the placebo group (p < 0.01). In the group of obese patients orlistat therapy reduced risk factors, serum insulin level and improved early arterial functional changes as assessed with the reductions of the mean velocity blood flow and peripheral pulse pressure following 3 months. The regression of morphological changes, as assessed with the reduction in intima - media thickness, was feasible over the six - month period.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 12/2005; 62(11):803-10. · 0.21 Impact Factor
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    ABSTRACT: It is well known that smoking is associated with an increase in arterial wall thickness. However, most studies of this problem have been undertaken in age and sex heterogenous groups, as well as in patients with already present other conventional risk factors. The aim of this study was to assess the effect of cigarette smoking on arterial wall thickness of the common carotid artery in asymptomatic pilots. The imaging of intima-media thickness of the posterior wall of the distal 1 cm of both common carotid arteries was performed using a B mode ultrasound device, in 39 pilots (37.05 +/- 6.66 years), for whom smoking was the single cardiovascular risk factor. Comparisons were made with 49 non-smokers (35.12 +/- 7.39 years). The posterior walls of both common carotid arteries were thicker in smokers (left, p < 0.05; right, p > 0,05). Intima-media thickness was significantly lower on the right side than on the left side in both smokers and non-smokers (p < 0.01). Cigarette smoking as the single cardiovascular risk factor was associated with the wall thickness of the carotid arteries in our study. This finding indicated that early atherosclerosis was already present in pilots-smokers entering middle age.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 05/2005; 62(5):365-70. · 0.21 Impact Factor
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    ABSTRACT: Postoperative recurrence of the liver hydatid disease befalls approximately 10-30% of patients. Preoperative or postoperative therapy with albendazole in single therapeutic protocol (800 mg/d, within 28 days) indicated the need to evaluate the hydatid cyst liquid protoscoleces viability. Morphological changes of protoscoleces following the treatment with drugs are not well known. To estimate the viability of protoscoleces after preoperative or postoperative albendazole therapy, and their ability for cystic metamorphosis. A prospective, randomized clinical trial included 30 patients with liver hydatid disease, treated with albendazole and surgically (I group), and 30 patients in the control group treated only surgically (II group). The concentration of albendazole and its active metabolite albendazole sulphoxide in the cysts contents were determined using HPLC. Estimation of protoscoleces viability was based on the established micromorphologic criteria, and compared between the patients treated with albendazole, and the patients treated only surgically. Biological assessment of the viability was performed on protoscoleces with uncertain signs of the disturbed viability (unchanged structure, evaginated, without movements) using intraperitoneal injection of 1 ml of protoscoleces prepared suspension to AO type of rats. The concentration of albendazole in cysts' contents ranged from 0 to 64.9 microg/ml, and of its active metabolite from 0.5 to 40.8 microg/ml. The presence of fully viabile protoscoleces in the albendazol treated patients was significantly lower than in the control group. A significant difference was noticed in the presence of disintegrated protoscoleces without movements in the albendazol treated group, compared to the control group. Biological assessment of the viability showed incapability of these protoscoleces for cystic metamorphoses. Low viability of parasites due to medicamentous therapy is very useful and important to surgeons, because the fertility of cysts is lower, and the risk of the disease recurrence is reduced.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 04/2005; 62(3):175-9. · 0.21 Impact Factor