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ABSTRACT: Thirty rats were divided into three groups, as sham, control and DMSO groups. Laparatomy was performed on each animal in the control and DMSO groups and common bile ducts were ligated. Common bile duct was observed but was not ligated for the rats in the sham group. Saline solution injection (1.5 mg/kg/intraperitoneally (i.p.)) was begun on the first day of surgical procedure and repeated once a day for the next 5 days. The same procedure was performed with DMSO (1.5 mg/kg/i.p.) instead of saline in the DMSO group. The rats were sacrificed on the postoperative seventh day, at which time venous blood and liver tissue specimens were taken.
On the 7th postoperative day, the bilirubin, AST, ALT, ALP and GGT levels of the control and DMSO groups were significantly higher in comparison with the sham group (p < 0.01). On the 7th postoperative day, the erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels of the control and DMSO groups were significantly lower than those of the sham group (p < 0.01), but there was no statistical difference between the two groups (p > 0.05). Erythrocyte and liver malondialdehyde (MDA) levels in the control and DMSO groups were significantly higher compared with the sham group (p < 0.01). However, the MDA levels were significantly lower in the DMSO group compared to the control group (p < 0.01).
It is stated that free oxygen radicals seem to play a role in the liver tissue injury, secondary to obstructive jaundice. In our experimental study, exogenic DMSO seems to have decreased lipid peroxidation and to have improved some of the parameters of liver tissue injury due to the obstructive jaundice in rats.
Acta chirurgica Belgica 08/2003; 103(4):392-5. · 0.43 Impact Factor
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ABSTRACT: To find out whether diabetes mellitus is a risk factor in patients who undergo laparoscopic cholecystectomy because of symptomatic gallbladder stones.
Eight hundred sixty-two patients with symptomatic gallbladder stones underwent laparoscopic cholecystectomy at our institution between January 1993 and July 2000. Age, sex, risk classification of the American Society of Anesthesiologists (ASA), laboratory tests, operative records, morbidity, and length of hospital stay for each patient were analyzed.
There were 184 (21%) diabetic and 678 (79%) nondiabetic patients. The ASA class I applied to 534 nondiabetic (control) patients (79%), and ASA class II to 161 diabetic (study) patients (88%). There was no significant difference between the diabetic and nondiabetic patients regarding leukocyte count, bilirubin, or amylase levels. Operative and postoperative complication rates were significantly higher in the diabetic patients. Conversion to open surgery was required in 19 of 678 patients in the control group (2.8%) and 13 of 184 in the study group (7.1%). The operative time and length of hospital stay were not significantly different in the two groups.
Although they had the same symptoms and laboratory findings, laparoscopic cholecystectomy in diabetic patients is associated with more morbidity and a higher conversion rate than in nondiabetic patients.
Journal of Laparoendoscopic & Advanced Surgical Techniques 11/2001; 11(5):281-4. · 1.40 Impact Factor
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ABSTRACT: To evaluate the role of laparoscopy in the diagnosis and treatment of unexplained acute abdominal pain.
Fifty-six patients with acute abdominal pain (41 women, 15 men; median age 27) who attended our hospital between July 1996 and July 1999 and in whom a definite diagnosis could not be made by conventional methods underwent diagnostic laparoscopy.
The laparoscopic procedure was performed under general anesthesia in 43 patients and local anesthesia in 13 patients. The median duration of laparoscopy was 16 minutes. The sensitivity and specificity of diagnostic laparoscopy were found to be 98% and 96%, respectively. The most frequent diagnosis was acute appendicitis (38%). Laparoscopic treatment of the surgical pathology was possible in 36 patients; in seven patients, conversion to laparotomy was necessary. The median postoperative hospital stay was 1 day in the diagnostic laparoscopy group. The median treatment cost was lower in the diagnostic laparoscopy group than in the therapeutic laparoscopy or laparotomy groups. There was no mortality or morbidity in the laparoscopy groups.
Laparoscopy is an effective method for the diagnosis and treatment of surgical pathologies in patients in whom the diagnosis cannot be made with physical examination and noninvasive methods.
Journal of Laparoendoscopic & Advanced Surgical Techniques 09/2000; 10(4):203-7. · 1.40 Impact Factor
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Transplantation Proceedings 06/1998; 30(3):839-41. · 1.00 Impact Factor
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ABSTRACT: The ischemia caused by the hepatic dearterialization as therapy for hepatic malignancies is transient because of the rapid formation of collaterals. In order to prevent this transient repeated ischemia has been suggested. An experimental study was planned to compare the collateral occurrence in persistent ischemia and transient repeated ischemia of the liver. Fourteen dogs (seven persistent ischemia, seven transient repeated ischemia) were used in this study. Hepatic dearterialization were performed in both groups. In the first group (persistent ischemia), the hepatic artery was ligated proximal to the gastroduodenal artery. In the second group (transient repeated ischemia), the hepatic artery was occluded externally in the same region as the first group by means of a device modified from 8 guage Foley catheter and after occlusion for one hour it was reopened. Occlusions were repeated twice in a day. Five dogs in the first group and six dogs in the second group completed a three week ischemia period and angiography were then performed in all. The dogs were sacrificed after the angiography and examined for possible abscess formation, arterial thrombosis, peritoneal adhesions and liver necrosis. After angiography, the two groups were also examined for collateral occurrence. Only one collateral occurred in the transient repeated ischemia group, but in the persistent ischemia group, collaterals occurred in all dogs. This difference between two groups is statistically significant (Fischer Absolute Chi Square Test, p = 0.013). Transient repeated ischemia is superior to persistent ischemia because of fewer collaterals, but in practise, total dearterialization of the liver is impossible.
HPB Surgery 02/1996; 10(1):35-40.
