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ABSTRACT: Tannins extracted from immature fruits of Terminalia chebula Fructus Retz. are considered as effective components promoting the process of wound healing. The objective of this study is to explore the optimal extraction and purification technology (OEPT) of tannins, while studying the use of this drug in the treatment of a cutaneous wound of rat as well as its antibacterial effects.
The content of tannin extracts was measured by the casein method, and antibacterial ability was studied by the micro-dilution method in vitro. In wound healing experiment, animals in group Ⅰ, Ⅱ and Ⅲ were treated with vaseline ointment, tannin extracts (tannin content: 81%) and erythromycin ointment, respectively (5 mg of ointment were applied on each wound). To evaluate the process of wound healing, selected pharmacological and biochemical parameters were applied.
After optimal extraction and purification, content of tannin extracts was increased to 81%. Tannin extracts showed the inhibition of Staphylococcus aureus and Klebsiella Pneumonia in vitro. After excision of wounds, on days 7 and 10, the percent of wound contraction of group Ⅱ was higher than that of group Ⅰ. After being hurt with wounds, on days 3, 7, and 10, the wound healing quality of group Ⅱ was found to be better than that of group Ⅰ in terms of granulation formation and collagen organization. After wound creation, on day 3, the vascular endothelial growth factor expression of group Ⅱ was higher than that of group Ⅰ.
The results suggest that tannin extracts from dried immature fruits of Terminalia chebula Fructus Retz. can promote cutaneous wound healing in rats, probably resulting from a powerful anti-bacterial and angiogenic activity of the extracts.
BMC Complementary and Alternative Medicine 01/2011; 11:86. · 2.24 Impact Factor
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ABSTRACT: Currently, a pandemic swine influenza A virus infection causes a huge negative impact on human beings all over the world. However, the methods of treatment are not satisfactory, therefore it is urgent for us to set up new theory and practice to fight against the intractable virus. Terminalia chebula Retz, as a kind of traditional Chinese medicine, widely distributes and has multiple pharmacological effects. Evidences in laboratory and clinic practice confirm us to the potential of Terminalia chebula Retz inhibiting influenza A virus infection. We thus hypothesize that acetone extracts (tannic acids, A) of Terminalia chebula Ret may as a new alternative treat influenza A infection based on holistic concept of traditional Chinese medicine principle.
African journal of microbiology research 04/2010; 4:497-499. · 0.54 Impact Factor
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ABSTRACT: fatty acids are considered to be effective components to promote wound healing and Lucilia sericata larvae are applied clinically to treat intractable wounds. We aimed to investigate the effect of fatty acid extracts from dried Lucilia sericata larvae on murine cutaneous wound healing as well as angiogenesis.
On day 7 and 10 after murine acute excision wounds creation, the percent wound contraction of fatty acid extracts group was higher than that of vaseline group. On day 3, 7 and 10 after wounds creation, the wound healing quality of fatty acid extracts group was better than that of vaseline group on terms of granulation formation and collagen organization. On day 3 after wounds creation, the micro vessel density and vascular endothelial growth factor expression of fatty acid extracts group were higher than that of vaseline group. Component analysis of the fatty acid extracts by gas chromatography-mass spectrometry showed there were 10 kinds of fatty acids in total and the ratio of saturated fatty acid, monounsaturated fatty acid and polyunsaturated fatty acid (PUFA) was: 20.57%:60.32%:19.11%.
Fatty acid extracts from dried Lucilia sericata larvae, four fifths of which are unsaturated fatty acids, can promote murine cutaneous wound healing probably resulting from the powerful angiogenic activity of the extracts.
Lipids in Health and Disease 03/2010; 9:24. · 2.17 Impact Factor
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ABSTRACT: Human has used maggot to treat diseases for thousands of years. In recent years, with abuse of antibiotic and the rising incidence of antibiotic resistance, maggot therapy, as a surgical alternative, is mainly applied to treat chronic infected wounds on account of its low cost, efficacy and safety. Its mechanisms are disinfection, bio-debridement and enhancement of tissue regeneration. Maggot therapy which serves as a kind of biological therapy is promising. However, living maggot therapy could result in inevitable complications, so that we should apply traditional Chinese medicine theory to investigate and develop new delivery method of maggot. The review summarizes the past and present of maggot therapy.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 12/2009; 34(24):3162-4.
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ABSTRACT: Taurine plays various important roles in a large number of physiological and pathological conditions in human body, such as the cytoprotective functions, antioxidant, anti-inflammatory and anti-apoptosis effects. Copper demonstrates a critical effect in the processes of wound healing, including induction of endothelial growth factor, angiogenesis, antimicrobial potency and expression and stabilization of extracellular matrix. Both copper and taurine are effective in accelerating wound healing, but it was rarely reported about the formation of copper complexes of taurine and the effect of the compound in wound healing. Generally speaking, to human body, organic compound could provide a better bioavailability than the inorganic ones. We thus hypothesize that taurine combined with copper would be a new therapeutic candidate for infected wound healing. We name the new compound copper-taurine (CT). Copper-taurine (CT) added into the wound dressings would not only reduce the risk of wound infection, but, more importantly, would stimulate wound repair directly. The sustained release of copper and taurine from the wound dressings into the wound site would together facilitate the wound healing more potently.
Medical Hypotheses 08/2009; 73(6):1048-50. · 1.39 Impact Factor
