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ABSTRACT: Quality of drinking water was comprehensively studied in Fusui County of Guangxi, a high-incidence area for liver cancer. The results indicated pond water was polluted the most severely, well water the least, and river water intermediately. The chemical indicators for water pollution were levels of ammonia, nitrite, humic acid, suspended substances, chemical oxygen demand, and biological oxygen demand. Quality of drinking water was worse in high incidence area for liver cancer than that in low-incidence one. Mortality of liver cancer correlated positively with the levels of nitrite, humic acid, chemical oxygen demand, and so on. These results provided a basis for further studies on the etiology of liver cancer.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 02/1994; 28(1):24-6.
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ABSTRACT: Ames test procedures were used to test 8 natural food extracts for their antimutagenic activity against the mutagenic activity induced in S. typhimurium strains TA98 and TA100 by aflatoxin B1 (AFB1) or metabolic extracts from A. versicolor or A. ochraceus. The tested substances were extracted repeatedly with acetone. The revertants induced by AFB1, metabolic extracts of A. versicolor or A. ochraceus were significantly decreased when extracts of the 8 natural foods were added to the media. The results showed that these extracts had marked inhibitory effects on the mutagenic activity induced by AFB1 or metabolic extracts of the two molds and also suggested that antimutagenic substances were present in these natural foods. These experiments provide a scientific basis for the study of food substances for the prevention of carcinogenesis. It is considered that these 8 natural food extracts produce marked antimutagenic effects and are practically valuable in the field of chemoprophylaxis of liver cancer in humans.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 06/1992; 279(1):35-40. · 2.85 Impact Factor
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ABSTRACT: A high performance liquid chromatographic (HPLC) method for the analysis of aflatoxin M1 (AFM1) in urine is described. Urine samples were treated with saturated lead acetate and AFM1 was extracted with chloroform. After washing with water to remove impurities the compound was derivatized with trifluoroacetic acid and the AFM1 derivative was analyzed quantitatively by HPLC. The sample pretreatment is simple and more selective. A good line correlation between AFM1 peak height and its concentration was obtained when AFM1 content was in the range of 50-400 pg. The ratio of recovery was 87.42%. Sensitivity is 0.01 ppb. The method is applicable to trace analysis. Results in urine of residents who live in the high/low liver cancer incidence area in Fushui county were the same as that of previous epidemiological investigation.
Biomedical Chromatography 04/1990; 4(2):83-6. · 1.97 Impact Factor
