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Publications (7)11.17 Total impact

  • Nippon rinsho. Japanese journal of clinical medicine 11/2004; 62 Suppl 10:396-400.
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    ABSTRACT: Krukenberg's tumor, an metastatic ovarian tumor originating from gastric cancer, is a disease with extremely poor prognosis, and it is rare for patients to survive for more than 2 years after the diagnosis. We encountered a patient in whom a long-term good prognosis could be obtained probably because of the effects of chemotherapy after the ovarian tumor extraction. This patient was treated by a combination of UFT and cisplatin. Enhancement of the antitumor effects by the concomitant use of 5-FU and cisplatin has been attracting attention, and the methods of administration of these drugs have been investigated by numerous researchers as FP therapy. It was characteristic to the treatment of our patient that 5-FU was administered in the form of oral UFT. We believe this was an important experience suggesting that this administration method is safe and effective, and even influences the long-term prognosis.
    Gan to kagaku ryoho. Cancer & chemotherapy 07/2004; 31(6):943-7.
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    ABSTRACT: The objectives of this study are to analyze the clinicopathologic features of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix and to discuss the management thereof. We examined 13 patients with VGPA. Clinical profiles, including patient age, clinical stage, surgical procedure, and outcome, were recorded. Pathologically, macroscopic features, polypoid tumor size, horizontal spread and depth of endophytic tumor, nuclear atypicality, mitotic count, lymph capillary space invasion, and lymph node metastasis were investigated. The median age of 13 patients was 45 years, with 10 and 3 patients staged Ib and IIb, respectively. All the patients underwent hysterectomy and pelvic lymphadenectomy and are alive without recurrence. Macroscopically, the tumor showed a polypoid pattern in 8 patients and a flat pattern in the remaining 5 patients. Polypoid tumor size ranged between 4 x 2 and 20 x 15 mm. Horizontal spread and depth of endophytic tumor ranged between 8 and 30 mm and between 3 and 11 mm, respectively. The tumor in all the 13 patients except 1 showed moderate nuclear atypicality. The mean mitotic count was 43/10 high-power fields. Lymph capillary space invasion was present in 4 patients, 1 of whom also had bulky lymph node metastases. VGPA has been reported to rarely involve lymph capillary space invasion or lymph node metastasis, leading some surgeons to conduct less radical surgeries such as conization. Nevertheless, we encountered patients with these pathologic risk factors. Much caution should be exercised in managing patients with VGPA.
    Gynecologic Oncology 02/2004; 92(1):64-70. · 3.69 Impact Factor
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    ABSTRACT: A patient with stage IIb cervical adenocarcinoma underwent Wertheim hysterectomy with pelvic lymphadenectomy and bilateral adenexectomy followed by radiotherapy. Review of histologic sections diagnosed villoglandular papillary adenocarcinoma (VGPA) with metastatic lymph nodes. The patient has been disease-free for 17 years. This patient is the third case of VGPA with lymph node metastasis ever reported.
    European Journal of Obstetrics & Gynecology and Reproductive Biology 12/2002; 105(2):186-8. · 1.63 Impact Factor
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    ABSTRACT: Recurrence of FIGO stage IA1 cervical adenocarcinoma is extremely rare. We herein report a patient with early invasive cervical adenocarcinoma who developed a recurrence in the vaginal stump. A 52-year-old female complained of contact bleeding. Biopsy of the uterine cervix verified cervical adenocarcinoma, and the patient underwent Okabayashi hysterectomy with pelvic lymphadnectomy and bilateral adnectomy. Histopathologic examination of the uterus revealed an invasive cancer 3 mm in depth. Neither lymph node metastasis nor lymph-vascular space invasion was observed. However, the depth of her normal cervical gland area was 2 mm only, and the cancer invasion involved an area which was deeper than the normal cervical gland area. The vaginal stump recurrence developed 4 years after surgery. The depth of invasion with reference to that of normal cervical glands may become a possible prognostic factor for early invasive cervical adenocarcinoma.
    Gynecologic Oncology 08/2001; 82(1):205-7. · 3.69 Impact Factor
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    ABSTRACT: BackgroundNo effective chemotherapy has been established for the treatment of ovarian clear cell adenocarcinomas. Based on the results of a sensitivity test in cultured cells, we investigated combination chemotherapy using irinotecan hydrochloride and mitomycin C. MethodsSix patients with ovarian clear cell, adenocarcinoma and evaluative lesions were infused with irinotecan (140 mg/m2) intravenously over 4 hours and mitomycin C (7 mg/m2) was infused over 60 minutes directly into the pleuroperitoneal cavity or intravenously. One course comprised 3 doses of each agent at 2-week intervals and patients received at least 2 courses. ResultsA complete response was obtained in 1 patient (maintained for 12 months so far) and a partial response in 1 patient (maintained for 3 months and followed by relapse with peritoneal dissemination). In 3 of the 4 patients without tumor regression, carcinomatous effusions decreased or disappeared. Myelosuppression and gastrointestinal side effects were grade II or less in severity and thus were considered tolerable. ConclusionBecause no chemotherapy regimens employing cisplatin are effective for ovarian clear cell adenocarcinomas, this regimen warrants further study.
    International Journal of Clinical Oncology 10/1996; 1(3):157-162. · 2.17 Impact Factor
  • Yasuo Hirai, Yoshio Shimizu, Satoshi Umezawa, Takaharu Yamawaki, Ikuno Fujimoto, Kazuhiro Yamauchi, Motoko Ikenaga, Atsuko Minami, Masafumi Tsuzuku, Katsuhiko Hasumi
    The Journal of the Japanese Society of Clinical Cytology. 01/1995; 34(4):751-756.
  • Hideo Teshima, Noriyuki Furuta, Jui-Tung Chen, Yoshio Shimizu, Ikuno Fujimoto, Kazuhiro Yamauchi, Katsuhiko Hasumi, Kazumasa Masubuchi, Morio Hirata
    The Journal of the Japanese Society of Clinical Cytology. 01/1990; 29(1):21-25.