Yasuhiro Yamamoto

Publications (3)3.13 Total impact

• Article: [A case of advanced pancreatic cancer responding well to S-1/gemcitabine combination therapy after gemcitabine therapy].

  Mariko Kuji, Yasuhiro Yamamoto, Chikayoshi Tani, Sachiko Kenno, Tatsuo Kobayashi
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  ABSTRACT: A 71-year-old male with unresectable pancreatic cancer treated with gemcitabine (GEM) by another doctor came to our hospital because of stenosis of duodenum and hydronephrosis. There was peritoneal dissemination in his abdominal cavity, and gastro-jejunostomy was performed. After surgery, GEM therapy was continued until he was judged as PD. The regimen was switched to S-1/GEM combination therapy. After that, the tumor marker was down to within normal range, and abdominal symptoms improved. He is now being treated as an outpatient. S-1/GEM combination therapy is effective for patients with unresectable advanced pancreatic cancer.
  Gan to kagaku ryoho. Cancer & chemotherapy 05/2011; 38(5):853-5.
• Article: [A case report of advanced cardiac cancer showing a complete response to TS-1 as neoadjuvant chemotherapy].

  Yasuhiro Yamamoto, Yasuhisa Kino, Kei Ohara, Sunao Onuma, Keiko Asai, Tatsuo Kobayashi, Toru Kono, Shinichi Kasai
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  ABSTRACT: A 69-year-old female had complaints of vomiting, appetite loss and feeling of pharyngeal obstruction. She was diagnosed with a 3'-shaped advanced cardiac cancer with esophageal invasion. A biopsy revealed poorly differentiated adenocarcinoma. The tumor was T3 (SE) N2, Stage IIIB indicating a poor prognosis. After informed consent, TS-1 was administrated as preoperative chemotherapy. Chemotherapy with TS-1 was very effective, and the tumor noticeably decreased. Next, total gastrectomy was performed. Histopathological findings revealed that the primary tumor and lymph node had become scarred and fibrous, indicating a complete response (Grade 3). In the future, TS-1 can be expected to display efficacy in neoadjuvant chemotherapy for patients with advanced gastric cancer who have poor prognoses.
  Gan to kagaku ryoho. Cancer & chemotherapy 05/2004; 31(4):579-83.
• Article: Adenosquamous carcinoma of the rectum showing endocrine-cell differentiation

  Toru Kono, Yasuhiro Yamamoto, Akitoshi Kakisaka, Yosihiko Tokusasi, Naoyuki Miyokawa, Shinichi Kasai
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  ABSTRACT: PURPOSE: Previous records of adenosquamous carcinomas with endocrinologic features rarely have been reported. Although the disease behaves in an extremely aggressive manner, chemotherapy after surgery has never been proposed. We used regional chemotherapy for treatment of unresectable liver metastases. METHODS: Hartmann colostomy was performed and 5-fluorouracil was infused into the hepatic artery for 15 weeks after the operation. RESULTS: Multiple liver metastases were present at the initial operation. Three months after the start of the chemotherapy, computed tomography showed that metastatic tumors in the liver had disappeared. The patient survived 18 months after the initial operation. CONCLUSION: This case report describes the first successful treatment with adjuvant regional chemotherapy of a patient who had an adenosquamous carcinoma with endocrine-cell differentiation in the rectum and liver metastases.
  Diseases of the Colon & Rectum 07/1999; 42(8):1089-1092. · 3.13 Impact Factor