Xiuye Xing

Publications (3)10.62 Total impact

• Article: Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.

  Han Zhao, Xinghua Xu, Xiuye Xing, Jianfeng Wang, Lin He, Yongyong Shi, Yuhua Shi, Yueran Zhao, Zi-Jiang Chen
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  ABSTRACT: Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder. A previous genome-wide association study (GWAS) identified five single nucleotide polymorphisms (SNPs) which were independently associated with PCOS in Han Chinese. To overcome population stratification, a family-based analysis was conducted to validate whether these five SNPs are associated with PCOS. A total of 276 family trios (828 participants) having a proband with PCOS were included in the family-based study. The transmission disequilibrium test (TDT) was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3. A positive association was observed for the SNP rs13429458 (P= 3.74 × 10(-5)). TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS. This family-based analysis enhances our previous case-control GWAS and provides further support for the role of susceptibility loci in PCOS.
  Human Reproduction 11/2011; 27(1):294-8. · 4.47 Impact Factor
• Article: Morphologically abnormal oocytes not capable of fertilization despite repeated strategies.

  Xiuye Xing, Han Zhao, Mei Li, Mei Sun, Yuan Li, Zi-Jiang Chen
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  ABSTRACT: To describe a case with repeated total fertilization failure due to oocyte defect. Case report. University hospital. A patient with repeated total fertilization failure. Assisted oocyte activation, intracytoplasmic sperm injection (ICSI) with calcium ionophore oocyte activation, donor semen, and donor oocytes. Fertilization, pregnancy, and live birth. Five cycles of IVF/ICSI were performed. In the first IVF cycle, 19 oocytes failed to fertilize. In the second ICSI attempt, 12 oocytes were retrieved and were not fertilized. In the third and fourth natural cycles, donor semen was used for IVF and ICSI, respectively, yet the oocytes could not be fertilized even by assisted activation. Then donor oocytes were used in the fifth cycle by ICSI. All five donated oocytes fertilized normally, and three embryos were transferred on day 3. Clinical pregnancy was confirmed, and a healthy girl weighing 3,200 g was delivered at 39 weeks of gestation by cesarean section. In cases of repeated fertilization failure caused by oocyte defects, oocyte donation seems to be a good choice for patients who wish to become pregnant.
  Fertility and sterility 03/2011; 95(7):2435.e5-7. · 3.97 Impact Factor
• Article: Association of vascular endothelial growth factor gene polymorphisms with recurrent spontaneous abortion in Chinese Han women.

  Xiuye Xing, Junhao Yan, Yueran Zhao, Li You, Yuehong Bian, Zi-Jiang Chen
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  ABSTRACT: An association of polymorphism -1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF -1154 with RSA in a well-defined group of Chinese Han patients. The VEGF -1154G/A genotype was detected by real-time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results. The allele frequencies of VEGF -1154G/A showed no significant difference between RSA patients and the normal controls (P = 0.183). The frequencies of VEGF -1154G/A genotypes were not significantly different between RSA patients and the normal controls (P = 0.228). Our study revealed that VEGF -1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.
  American Journal Of Reproductive Immunology 10/2010; 65(5):521-5. · 2.17 Impact Factor