Publications (2)8.81 Total impact

  • J Su, X B Yang, L X Wang, B Xu, L H Zhang
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    ABSTRACT: (Sp)-octyl 8-chloroadenosine 3',5'-cyclophosphate(OCC), a newly synthesized cAMP analog, strongly induced growth inhibition and differentiation in human leukemia HL-60 cells. The effects were dose- and time-dependent and irreversible. In flow cytometry, OCC brought about a block at the G1 phase of HL-60 cell cycle. Determined by incorporation assay, OCC was shown to strongly inhibit DNA synthesis without affecting the synthesis of RNA and protein in HL-60 cells. OCC activated the protein kinase A(PKA) in the cytosol of HL-60 cells and inhibited its binding to cAMP. The activities of PKA in the cytosol of HL-60 cells treated with OCC were more significantly increased than those in control cells. It can be concluded that OCC binds itself to PKA in competition with cAMP and, as a result, activates PKA.
    Yao xue xue bao = Acta pharmaceutica Sinica 02/1996; 31(9):641-6.
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    ABSTRACT: Stereoselectivity was found during the coupling reaction, to form 2',5'- and 3',5'-linked di- and triadenylyl methylphosphonate. The configuration of phosphorus was determined by 1HNMR NOE.
    Nucleic Acids Research 08/1993; 21(14):3245-8. DOI:10.1093/nar/21.14.3245 · 8.81 Impact Factor