-
[show abstract]
[hide abstract]
ABSTRACT: The assessment of myocardial viability has become an important aspect of the diagnostic and prognostic work-up of patients with coronary artery disease. Technetium-99m labelled sestamibi ((99m)Tc-MIBI) myocardial perfusion imaging may underestimate the viability of ischaemic myocardium. Technetium-99m labelled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime ((99m)Tc-HL91) is a hypoxia-avid agent which can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The aim of this study was to evaluate uptake character of ischaemic viable myocardium and diagnostic performance of single-photon emission computed tomography (SPECT) imaging by (99m)Tc-HL91 and (99m)Tc-MIBI in detecting ischaemic viable myocardium in coronary heart disease.
A total of 41 patients with coronary artery disease were recruited from March 2008 to May 2009. For detecting ischaemic viable myocardium, SPECT imaging by (99m)Tc-HL91 and (99m)Tc-MIBI were performed in all patients before coronary revascularization. Six patients with single ischaemic myocardial segment received a 2-day SEPCT/CT imaging protocol and the uptake of (99m)Tc-HL91 in ischaemic myocardium was quantitatively analysed. The remaining 35 patients received a 1-day (99m)Tc-HL91 and (99m)Tc-MIBI SPECT imaging protocol. Resting (99m)Tc-MIBI myocardial perfusion imaging in 3-18 months after revascularization was used as the standard methodology to evaluate the myocardial viability.
In 41 patients, 66 ischaemic myocardial segments were proven to be viable and 12 to be necrotic by resting (99m)Tc-MIBI myocardial perfusion imaging after coronary revascularization. Furthermore, 60 viable segments with negative uptake of (99m)Tc-MIBI showed positive uptake of (99m)Tc-HL91. The remaining six viable segments and 12 necrotic segments showed both negative uptake of (99m)Tc-HL91 and (99m)Tc-MIBI. The sensitivity, specificity, accuracy, Younden Index, positive predictive value and negative predictive value for evaluating ischaemic viable myocardium were 90·9%, 100%, 92·3%, 90·9%, 100% and 66·7%, respectively. Ischaemic viable myocardium had the negative (99m)Tc-MIBI uptake and positive (99m)Tc-HL91 uptake, which demonstrated a mismatched uptake character. Quantitative analysis indicated the uptake of (99m)Tc-HL91 in viable myocardium was increasing in the first 1-3 h and remained stable at the 3-4 h after injection.
Functional SPECT imaging with (99m)Tc-HL91 and (99m)Tc-MIBI can be used to detect the seriously ischaemic but viable myocardium with a mismatched uptake character. The uptake of (99m)Tc-HL91 in the viable myocardium reached a stable level at 3-4 h after injection.
Clinical Physiology and Functional Imaging 01/2012; 32(1):25-32. · 1.33 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: OBJECTIVES: The purpose is to identify the role of cardiovascular parameters of computed tomographic pulmonary angiography (CTPA) to assess pulmonary vascular resistance (PVR) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). BACKGROUND: The assessment of PVR is of great importance in the management of patients with CTEPH. The role of CPTA in assessment of PVR of CTEPH remains to be explored. METHODS: Clinical and radiological data of 90 patients (55 men, age 17-84years) with CTEPH were retrospectively reviewed in this study. All patients received CTPA before right-heart catheterization. Cardiovascular parameters and Pulmonary Artery Obstruction Indices including Qanadli Index and Mastora Index were evaluated on CTPA. Hemodynamic PVR was calculated with the standard formula according to data from right-heart catheterization. The correlation of cardiovascular parameters of CTPA and PVR was analyzed. RESULTS: In Cardiovascular parameters, neither Qanadli Index(r=0.134, p=0.208) nor Mastora Index (r=0.149, p=0.90) did correlate with PVR. Cobb angle(r=0.613, p=0.000), the ratio of right to left ventricular area(r=0.422, p=0.000)and the ratio of right to left ventricular transverse diameter (r=0.410, p=0.000) respectively correlated with PVR. By receiver operating characteristic curve analysis, a Cobb angle cutoff value of 67.55° had a sensitivity of 72.5% and a specificity of 84.0% to determine PVR ≥1000 (dyn.sec/cm(5)) and its Area Under Curve is (0.800±0.048). By stepwise linear regression analysis, Cobb angle was only one variable (R=0.601) shown to be independently associated with PVR, leading to the following equation: PVR=25.796×Cobb angle-585.935(F=37.929, p=0.000). CONCLUSION: The analysis of CTPA-derived cardiovascular parameters, especially the Cobb angle, is a reliable tool for estimating PVR in patients with CTEPH, but Pulmonary Artery Obstruction Indices do not correlate with PVR.
International journal of cardiology 08/2011; · 7.08 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The aim was to investigate the role of computed tomographic pulmonary angiography (CTPA) in the assessment of severity and right ventricular function in chronic thromboembolic pulmonary hypertension (CTEPH).
Clinical and radiological data of 56 patients with CTEPH January 2006-October 2009 were retrospectively reviewed in the present study. All patients received CTPA with a 64-row CT using the retrospective ECG-Gated mode before digital subtraction pulmonary angiography and right-heart catheterization. CTPA findings including Right Ventricular diameter (RVd) and left ventricular diameter (LVd) were measured at the end diastole. CT Pulmonary Artery Obstruction Indexes including Qanadli Index and Mastora Index were used in the assessment of severity of pulmonary arterial obstruction. Hemodynamic parameters and pulmonary hypertension classification were evaluated by right-heart catheterization in all patients. Right ventricular function was measured with echocardiography in 49 patients.
Qanadli Index and Mastora Index respectively were (37.93±14.74)% and (30.92±16.91)%, which showed a significant difference (Z=-5.983, P=0.000) and a good correlation (r=0.881, P=0.000). Neither Qanadli nor Mastora Index correlated with pulmonary hypertension classification (r=-0.009, P=0.920) or New York Heart Association heart function classification (r=-0.031, P=0.756). Neither Qanadli nor Mastora Index correlated with any echocardiographic right ventricular parameters (P>0.05), while RVd/LVd by CTPA correlated with echocardiographic right ventricular functional parameters (P<0.05). Both Qanadli (r=-0.288, P=0.006) and Mastora Index (r=-0.203, P=0.032) demonstrated a weakly negative correlation with SPO2. CTPA findings correlated with hemodynamic variables. Backward linear regression analysis revealed that the RVd/LVd, Right Ventricular Anterior Wall Thickness (RVAWT), Main Pulmonary Artery trunk diameter (MPAd) were shown to be independently associated with mean Pulmonary Artery Pressure (mPAP) levels (model: r2=0.351, P=0.025; RVd/LVd: beta=11.812, P=0.000; RVAWT: beta=2.426, P=0.000; MPAd: beta=0.677, P=0.003).
Computed tomographic pulmonary angiography is a valuable tool to evaluate hemodynamics, right ventricular function of CTEPH, but neither Qanadli Index nor Mastora Index can reflect pulmonary arterial obstruction in CTEPH accurately.
European journal of radiology 10/2010; 80(3):e462-9. · 2.65 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: ObjectiveTo analyze the value of CTPA in assessing the dissolve of embolus and the function of the right ventricle dynamically.MethodsTwenty-three cases of massive pulmonary embolism were analyzed retrospectively. The pulmonary artery obstruction index and the right ventricular function parameters were collected and analyzed on CTPA before thrombolytic therapy, 24 hours and 14 days after therapy, respectively.ResultsThe pulmonary artery obstruction index decreased gradually, and there was significant difference before therapy, 24 hours and 2 weeks after therapy. Twenty-four hours after therapy, the maximal short axes diameter and the maximal transverse area of right ventricle(RVd, RVs) decreased significantly, the maximal short axes diameter and the maximal transverse area of left ventricle(LVd, LVs) increased significantly, and the RVd/LVd, RVs/LVs decreased apparently. The pulmonary artery symbolic pressure before and 24 hours after therapy were apparently different. There was no significant difference between azygos vein, the super vena cava, the main pulmonary artery and vein reflux before and after therapy.ConclusionCTPA can evaluate the pulmonary artery obstruction degree and right ventricular function dynamically.
Journal of Nanjing Medical University.
