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ABSTRACT: Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the beta-amyloid protein (Aβ) in small cerebral vessels, which is considered a common cause of intracerebral hemorrhage (CAAH) in elderly people. Little is known about the properties of serum naturally occurring anti-Aβ antibodies in patients with CAAH. We investigated the avidity and levels of anti-Aβ antibodies in 20 patients and 20 age-matched healthy controls by an enzyme-linked immunosorbent assay with thiocyanate elution. Our study revealed that both the levels and the avidity of these endogenous anti-Aβ antibodies were lower in patients with CAAH than in controls, which may be a new mechanism for the impaired clearance of cerebral Aβ and have important implications for the development of immune-based therapeutic strategies for CAA.
The International journal of neuroscience 10/2010; 120(12):760-4. · 0.86 Impact Factor
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ABSTRACT: To compare the therapeutic effects of aspiration via a directional soft tube and conservative treatment in patients with mild hemorrhage in the basal ganglion.
Seventy-five patients with mild cerebral hemorrhage (10~30 ml) were randomly divided into two groups for aspiration treatment with minimally invasive directional soft tube placement (minimally invasive group, n=36) and conservative treatment (medication group, n=39). The patients in the two groups had comparable mean GCS scores of 11-15 on admission. The clinical outcomes of the patients were compared between the two groups.
In the minimally invasive group, complete removal or absorption of the hematoma occurred within an average of 3.8 days, significantly shortened in comparison with the 24 days in the medication group. The short-term (1 month) follow-up of the patients showed good neurological recovery in 58% of the patients in the minimally invasive group, significantly greater than the rate of 29% in the medication group; 6 months after the treatment, good neurological recovery was achieved in 50% of the patients in the minimally invasive group, but only 16% in the medication. No death occurred in the minimally invasive group, and 2 patients died in the medication group. The cost of hospitalization averaged 5136.3 Yuan in the minimally invasive group and 11843.6 Yuan in the medication group.
Compared with conservative treatment, the minimally invasive treatment with soft tube placement can significantly shorten the hospital stay, promote neurological function recovery, lower the mortality rate, and reduce the cost of hospitalization.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 09/2008; 28(8):1352-3.
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ABSTRACT: To explore the expression of transforming growth factor beta1 (TGFbeta1) and its type I receptors activin-like kinase 1 (ALK1) and ALK5 mRNA in the development of brain arteriovenous malformation (BAVM).
The mRNA expressions of TGFbeta1, ALK1and ALK5 were detected with semiquantitative RT-PCR in patients with BAVM.
The expressions of TGFbeta1 and ALK5 mRNA increased significantly in BAVM, and their relative expression quantity were 0.777-/+0.047 and 0.585-/+0.074, respectively. However, ALK1 mRNA expression declined significantlies with a relative expression of 0.173-/+0.044 in comparison with the control group (0.720-/+0.098, P<0.01).
The balance of TGFbeta1 and its type I receptors ALK1 and ALK5 mRNA expressions may play important role in the development of BAVM.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 06/2006; 26(5):675-7.
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Wei Quan,
Tie-lin Li,
Guang-zhong Chen,
Xiao-dan Jiang,
Ru-xiang Xu,
Yi-quan Ke,
Chuan-zhi Duan,
Jian-ping Lü,
Hao Zhang,
Wei Xie,
Wen-jun Zhong,
Ying-dong Chen,
Fan-fan Chen
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ABSTRACT: To assess the value of (1)H-magnetic resonance spectroscopy ((1)H-MRS) in evaluating cerebral vasospasm resulting from subarachnoid hemorrhage (SAH).
Six dogs were subjected to autologous non-heparinized blood injection via cisternal puncture twice at one-day interval to establish models of SAH, and another 6 received injections with normal saline in an identical manner. (1)H-MRS scan was performed on the 3rd, 7th and 14th days after the injections to measure the changes of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho). After the (1)H-MRS scan, all the dogs underwent brain digital subtraction angiography (DSA) for determining the basilar artery diameter.
DSA results on day 3 presented development of obvious vasospasm of the basilar artery, which was most evident on day 7 and recovered obviously on day 14. (1)H-MRS results demonstrated obvious changes of NAA, Cho and Cr on days 3 and 7 in SAH model group, and NAA declined to the lowest level on day 3 followed by gradual ascending till reaching the normal level on day 14. Cho decreased slightly on day 3, then increased and reached the peak level on day 7 and then decreased. Cr rose steadily from day 3 to 14, but since day 7, the rise slowed down obviously and Cr maintain a level not significantly different from that on day 14 (P>0.05). The functional results of (1)H-MRS were consistent with the DSA results.
(1)H-MRS can be used to monitor the development of cerebral vasospasm resulting from SAH as a good evaluation method for functional imaging.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 03/2006; 26(3):352-4.
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ABSTRACT: Surgical resection of brainstem lesions has a high risk of morbidity, because vital fasciculi in the brainstem can be damaged along the entry routes. Diffusion tensor imaging (DTI) is an in vivo method for mapping white matter fiber tracts in the brain.
To summarize the experience of surgical treatment of brainstem lesions with the assistance of DTI and fiber tractography.
A retrospective analysis clinical data of nine patients with brainstem lesions were investigated between July 2007 and September 2009. The analysis included age distribution, clinical presentation, pre- and postoperative modified Rankin score (mRS), and surgical approach. DTI and fiber tractography were used to reconstruct the corticospinal tracts and the medial lemnisci.
DTI and fiber tractography showed that most of the corticospinal tracts were compressed anteriorly or anterolaterally, except for one case (posteriorly). All the medial lemnisci were displaced posteriorly or posterolaterally. Individualized surgical approaches were designed according to the information provided by DTI and fiber tractography. Total resection was achieved in two patients with brainstem cavernomas and two patients with pilocytic astrocytoma. Partial resection was performed in the other patients. The neurological functional status was better than preoperative period in eight patients, one patient with medulla oblongata astrocytoma deteriorated. The preoperative average mRS score was 2.22 points. At the time of the last follow-up, the average postoperative score had improved by 0.56 to 1.66 points.
DTI and fiber tractography can provide valuable information regarding the relationship between the principal fiber tracts and brainstem lesions, which is useful in neurosurgical planning.
Neurology India 58(6):886-90. · 0.96 Impact Factor
