Vicenç Martínez

Publications (2)4.81 Total impact

• Article: Second, third, and fourth head and neck tumors. A progressive decrease in survival.

  Xavier León, Vicenç Martínez, Montserrat López, Jacinto García, María Del Prado Venegas, Eduard Esteller, Miquel Quer
  [show abstract] [hide abstract]
  ABSTRACT: BACKGROUND: Patients with a first head and neck carcinoma have a high risk of successive neoplasms, many of which appear again in the head and neck. Second head and neck tumors have a poorer prognosis than first tumors, but data about the prognosis of third and fourth tumors in the head and neck are lacking. METHODS: We carried out a retrospective study of 4298 patients with a primary head and neck carcinoma. Survival and the characteristics of the first tumor, second tumor, and any successive tumors in the head and neck were analyzed. RESULTS: Second and successive tumors showed a tendency to appear more frequently in the oral cavity and oropharynx and had a lower stage than that of index tumors. Five-year survival rates after a first, second, third, and fourth tumors in the head and neck were 67.6%, 56.1%, 45.0%, and 32.1%, respectively. CONCLUSION: Survival decreased progressively with every new head and neck tumor. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
  Head & Neck 02/2012; · 2.40 Impact Factor
• Source

  Available from: Jacinto Garcia Lorenzo

  Article: Risk of third and fourth tumors in patients with head and neck cancer.

  Xavier León, Vicenç Martínez, Montserrat López, Jacinto García, Miquel Quer
  [show abstract] [hide abstract]
  ABSTRACT: The objective of our study was to analyze the incidence and location of second and subsequent tumors in patients after an index head and neck carcinoma. A retrospective study was made by reviewing clinical data prospectively collected from 3631 patients with head and neck cancer. Incidence, location, and histology of the second, third, and fourth tumors was evaluated. During the follow-up, 839 second tumors, 147 third tumors, and 35 fourth tumors were diagnosed. The annual hazard ratio was 3.8% for second tumors, 5.1% for third tumors, and 7.8% for fourth tumors. The risk of second and subsequent neoplasms remained constant throughout the follow-up. There were significant differences in the risk of appearance between the second and third tumors (p < .0001), and between the third and fourth tumors (p = .005). Patients with a second tumor after an index head and neck carcinoma have an increased risk for developing subsequent tumors.
  Head & Neck 02/2010; 32(11):1467-72. · 2.40 Impact Factor