Suzanne Kavic

Publications (2)19.36 Total impact

• Article: Rectus sheath hematoma after transvaginal follicle aspiration: a rare complication of in vitro fertilization.

  Jeff G Wang, Megan J Huchko, Suzanne Kavic, Mark V Sauer
  [show abstract] [hide abstract]
  ABSTRACT: To discuss the diagnosis and management of rectus sheath hematomas after transvaginal follicle aspiration. Case report. A single healthy patient in an academic IVF center. A healthy patient undergoing routine transvaginal follicle aspiration for IVF. CT scan, serial phlebotomy, IV fluid, in-patient observation. Condition at discharge. Patient was successfully managed with conservative measures. After the initial decline, serial hematocrits were stable over 24 hours without any operative interventions. Rectus sheath hematomas are rare complications of IVF and can be managed conservatively.
  Fertility and sterility 08/2005; 84(1):217. · 3.97 Impact Factor
• Article: Vascular endothelial growth factor receptor 2-mediated angiogenesis is essential for gonadotropin-dependent follicle development.

  Ralf C Zimmermann, Tipton Hartman, Suzanne Kavic, Samuel A Pauli, Peter Bohlen, Mark V Sauer, Jan Kitajewski
  [show abstract] [hide abstract]
  ABSTRACT: Gonadotropins induce ovarian follicle growth that is coincident with increased follicular vasculature, suggesting a role of angiogenesis in follicle development. Functional studies performed in nonhuman primates show that administration of substances that inactivate VEGF block the development and function of preovulatory follicles as demonstrated by histological analysis or hormone measurements. Blockage of function of VEGF receptor 2 (VEGFR-2) alters follicular hormone secretion, suggesting that the intraovarian effect of VEGF might be mediated by this receptor. The specific mechanism by which follicular development was blocked in these previous studies remains unclear, however. Here we characterize the intraovarian role of VEGFR-2 activity on follicular development by choosing a model in which active feedback is absent, the prepuberally hypophysectomized mouse. Hypophysectomy prevents advanced follicle growth and maturation; however, follicle development to the preovulatory stage can be stimulated by administration of gonadotropins. We report that exogenously administered gonadotropins are unable to drive follicle development to the preovulatory stage in the presence of antiangiogenic agent, VEGFR-2-neutralizing Ab's. This inhibition of follicular development is caused by arrests to both angiogenesis and antrum formation. We conclude that the intraovarian VEGF/VEGFR-2 pathway is critical for gonadotropin-dependent angiogenesis and follicular development.
  Journal of Clinical Investigation 10/2003; 112(5):659-69. · 15.39 Impact Factor