Shyoko Honiden

Yale-New Haven Hospital, New Haven, Connecticut, United States

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Publications (16)63.11 Total impact

  • Shyoko Honiden · Silvio Inzucchi ·

    Seminars in Respiratory and Critical Care Medicine 11/2015; 36(06):859-869. DOI:10.1055/s-0035-1565253 · 2.71 Impact Factor
  • Shyoko Honiden · Jonathan M Siner ·

    Clinics in chest medicine 09/2015; 36(3):xv-xvi. DOI:10.1016/j.ccm.2015.07.002 · 2.07 Impact Factor
  • Shyoko Honiden · Geoffrey R Connors ·
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    ABSTRACT: ICU-acquired weakness is a common problem and carries significant morbidity. Despite evidence that early mobility can mitigate this, implementation outside of the research setting is lagging. Understanding barriers at the systems as well as individual level is a crucial step in successful implementation of an ICU mobility program. This includes taking inventory of waste, overburden and inconsistencies in the work environment. Appreciating regulative, normative as well as cultural forces at work is critical. Finally, key personnel, which include organizational leaders, innovation champions and end users of the proposed change need to be accounted for at each step during program implementation. Copyright © 2015 Elsevier Inc. All rights reserved.
    Clinics in chest medicine 09/2015; 36(3):431-40. DOI:10.1016/j.ccm.2015.05.006 · 2.07 Impact Factor

  • Chest 10/2014; 146(4_MeetingAbstracts):801A. DOI:10.1378/chest.1991723 · 7.48 Impact Factor
  • Quynh N Hoang · Margaret A Pisani · Silvio Inzucchi · Buqu Hu · Shyoko Honiden ·
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    ABSTRACT: Purpose: Hyperglycemia is common during critical illness and can adversely affect clinical outcomes. We sought to determine the prevalence of undiagnosed diabetes among medical intensive care unit (MICU) patients with stress hyperglycemia and the association between baseline glycemic control and mortality. Materials and methods: A prospective, observational cohort study was performed at a tertiary care MICU. Hemoglobin A1c (HbA1c) levels were obtained from any patient who developed hyperglycemia and all known diabetic patients. We assessed the prevalence of undiagnosed diabetes (defined by HbA1c) among patients with stress hyperglycemia, and the association between baseline glycemic control and mortality. Results: We enrolled 299 patients. One hundred two (34.1%) had no history and 197 (65.9%) had a history of diabetes. Of the nondiabetic patients, 14 (13.7%) had an HbA1c of at least 6.5%. There was a significant difference in mortality between patients with HbA1c less than 6.5% and those with HbA1c of at least 6.5% (19.3% vs 11.7%, P=.038), despite similar Acute Physiology and Chronic Health Evaluation II scores. There was no significant difference in demographic characteristics between these groups. Multivariable logistic regression revealed lower HbA1c levels to be significantly associated with increased hospital mortality (odds ratio, 1.92; 95% confidence interval, 1.30-2.85; P=.001). Conclusion: A significant number of MICU patients with stress hyperglycemia have undiagnosed diabetes. Hyperglycemia with lower baseline HbA1c was associated with increased mortality.
    Journal of Critical Care 06/2014; 29(6). DOI:10.1016/j.jcrc.2014.06.007 · 2.00 Impact Factor
  • Shetty · Shyoko Honiden ·

    Endocrine Practice 07/2012; 18(4):620-620. · 2.81 Impact Factor
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    ABSTRACT: To report our preliminary experience with the revised, more conservative Yale insulin infusion protocol (IIP) that targets blood glucose concentrations of 120 to 160 mg/dL. We prospectively tracked clinical responses to the new IIP in our medical intensive care unit (ICU) by recording data on the first 115 consecutive insulin infusions that were initiated. All blood glucose values; insulin doses; nutritional support including intravenous dextrose infusions; caloric values for enteral and parenteral nutrition; and use of vasopressors, corticosteroids, and hemodialysis or continuous venovenous hemodialysis were collected from the hospital record. The IIP was used 115 times in 90 patients (mean age, 62 [±14 years]; 51% male; 35% ethnic minorities; 66.1% with history of diabetes). The mean admission Acute Physiology and Chronic Health Evaluation II score was 24.4 (±7.5). The median duration of insulin infusion was 59 hours. The mean baseline blood glucose concentration was 306.1 (±89.8) mg/dL, with the blood glucose target achieved after a median of 7 hours. Once the target was reached, the mean IIP blood glucose concentration was 155.9 (±22.9) mg/dL (median, 150 mg/dL). The median insulin infusion rate required to reach and maintain the target range was 3.5 units/h. Hypoglycemia was rare, with 0.3% of blood glucose values recorded being less than 70 mg/dL and only 0.02% being less than 40 mg/dL. In all cases, hypoglycemia was rapidly corrected using intravenous dextrose with no evident untoward outcomes. The updated Yale IIP provides effective and safe targeted blood glucose control in critically ill patients, in compliance with recent national guidelines. It can be easily implemented by hospitals now using the original Yale IIP.
    Endocrine Practice 12/2011; 18(3):363-70. DOI:10.4158/EP11260.OR · 2.81 Impact Factor
  • Shyoko Honiden · Sonya S Abdel-Razeq · Mark D Siegel ·
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    ABSTRACT: Hypertensive disorders, postpartum hemorrhage, and sepsis are the most common indications for intensive care unit admission among obstetric patients. In general, ICU mortality is low, and better than would be predicted using available mortality prediction tools. Provision of care to this special population requires an intimate understanding of physiologic changes that occur during pregnancy. Clinicians must be aware of the way various diagnostic and treatment choices can affect the mother and fetus. Most clinically necessary radiographic tests can be safely performed and fall under the maternal radiation exposure limit of less than 0.05 Gray (Gy). Careful attention must be paid to acid-base status, oxygenation, and ventilation when faced with respiratory failure necessitating intubation. Cesarean delivery can be justified after 4 minutes of cardiac arrest and may improve fetal and maternal outcomes. The treatment of obstetric patients in the ICU introduces complexities and challenges that may be unfamiliar to many critical care physicians; teamwork and communication with obstetricians is crucial.
    Journal of Intensive Care Medicine 08/2011; 28(2). DOI:10.1177/0885066611411408 · 7.21 Impact Factor
  • Megan Panico · Margaret Pisani · Grace Jenq · Katy Araujo · Shyoko Honiden ·

    American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado; 05/2011
  • Shyoko Honiden · Silvio E Inzucchi ·
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    ABSTRACT: Hyperglycemia is common in critical illness and has been associated with increased morbidity and mortality. An era of tight glucose control began when intensive insulin therapy was shown to improve outcomes in a single-center randomized trial. More recently, with the publication of additional studies, questions have been raised regarding the efficacy and safety of intensive glycemic management. This article will review the biologic mechanisms that may help us understand why and how hyperglycemia and insulin are relevant in critical illness. We will then explore insights gleaned from available clinical trials. Finally, we will discuss specific areas of controversy that relate to the implementation of glycemic control in the intensive care unit, such as the ideal glucose target and the importance of hypoglycemia.
    Journal of Intensive Care Medicine 11/2010; 26(3):135-50. DOI:10.1177/0885066610387892 · 7.21 Impact Factor
  • Shyoko Honiden · Mark D Siegel ·
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    ABSTRACT: Physical and psychological distress is exceedingly common among critically ill patients and manifests generically as agitation. The dangers of over- and undertreatment of agitation have been well described, and the intensive care unit (ICU) physician must strike a balance in the fast-paced, dynamic ICU environment. Identification of common reversible etiologies for distress may obviate the need for pharmacologic therapy, but most patients receive some combination of sedative, analgesic, and neuroleptic medications during the course of their critical illness. As such, understanding key pharmacologic features of commonly used agents is critical. Structured protocols and objective assessment tools can optimize drug delivery and may ultimately improve patient outcomes by reducing ventilator days, ICU length of stay, and by reducing cognitive dysfunction.
    Journal of Intensive Care Medicine 07/2010; 25(4):187-204. DOI:10.1177/0885066610366923 · 7.21 Impact Factor
  • Shyoko Honiden · John R McArdle ·
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    ABSTRACT: The exact prevalence of obesity among critically ill patients is not known, but some evidence suggests that in the United States one in four patients in the intensive care unit is obese. The authors review the physiologic alterations in obesity that are relevant in critical illness and highlight some common diseases associated with obesity. Various practical challenges in the care of the critically ill obese patient, including drug dosing, are also reviewed.
    Clinics in chest medicine 10/2009; 30(3):581-99, x. DOI:10.1016/j.ccm.2009.05.007 · 2.07 Impact Factor
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    Shyoko Honiden · Michelle N Gong ·
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    ABSTRACT: Recently, many studies have investigated the immunomodulatory effects of insulin and glucose control in critical illness. This review examines evidence regarding the relationship between diabetes and the development of acute lung injury/acute respiratory distress syndrome (ALI/ARDS), reviews studies of lung injury related to glycemic and nonglycemic metabolic features of diabetes, and examines the effect of diabetic therapies. A MEDLINE/PubMed search from inception to August 1, 2008, was conducted using the search terms acute lung injury, acute respiratory distress syndrome, hyperglycemia, diabetes mellitus, insulin, hydroxymethylglutaryl-CoA reductase inhibitors (statins), angiotensin-converting enzyme inhibitor, and peroxisome proliferator-activated receptors, including combinations of these terms. Bibliographies of retrieved articles were manually reviewed. Available studies were critically reviewed, and data were extracted with special attention to the human and animal studies that explored a) diabetes and ALI; b) hyperglycemia and ALI; c) metabolic nonhyperglycemic features of diabetes and ALI; and d) diabetic therapies and ALI. Clinical and experimental data indicate that diabetes is protective against the development of ALI/ARDS. The pathways involved are complex and likely include effects of hyperglycemia on the inflammatory response, metabolic abnormalities in diabetes, and the interactions of therapeutic agents given to diabetic patients. Multidisciplinary, multifaceted studies, involving both animal models and clinical and molecular epidemiology techniques, are essential.
    Critical care medicine 07/2009; 37(8):2455-64. DOI:10.1097/CCM.0b013e3181a0fea5 · 6.31 Impact Factor
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    Michael L Schilsky · Shyoko Honiden · Lindsay Arnott · Sukru Emre ·
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    ABSTRACT: Survival of patients presenting with acute liver failure (ALF) has improved because of earlier disease recognition, better understanding of pathophysiology of various insults leading to ALF, and advances in supportive measures including a team approach, better ICU care, and liver transplantation. This article focuses on patient management and evaluation that takes place in the ICU for patients who have acute liver injury. An organized team approach to decision making about critical care delivered during this period of time is important for achieving a good patient outcome.
    Clinics in chest medicine 04/2009; 30(1):71-87, viii. DOI:10.1016/j.ccm.2008.10.001 · 2.07 Impact Factor
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    ABSTRACT: To investigate whether timing of intensive insulin therapy (IIT) after intensive care unit (ICU) admission influences outcome. Single-center prospective cohort study in the 14-bed medical ICU of a 1,171-bed tertiary teaching hospital. The study included 127 patients started on ITT within 48 h of ICU admission (early group) and 51 started on ITT thereafter (late group); the groups did not differ in age, gender, race, BMI, APACHE III, ICU steroid use, admission diagnosis, or underlying comorbidities. The early group had more ventilator-free days in the first 28 days after ICU admission (median 12 days, IQR 0-24, vs. 1 day, 0-11), shorter ICU stay (6 days, IQR 3-11, vs. 11 days, vs. 7-17), shorter hospital stay (15 days, IQR 9-30, vs. 25 days, 13-43), lower ICU mortality (OR 0.48), and lower hospital mortality (OR 0.27). On multivariate analysis, early therapy was still associated with decreased hospital mortality (ORadj 0.29). The strength and direction of association favoring early IIT was consistent after propensity score modeling regardless of method used for analysis. Early IIT was associated with better outcomes. Our results raise questions about the assumption that delayed administration of IIT has the same benefit as early therapy. A randomized study is needed to determine the optimal timing of therapy.
    Intensive Care Medicine 06/2008; 34(5):881-7. DOI:10.1007/s00134-007-0978-3 · 7.21 Impact Factor
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    ABSTRACT: To examine physician practice in, and the costs of, prescribing inhaled bronchodilators to mechanically ventilated patients who do not have obstructive lung disease. This was a prospective cohort study at 2 medical intensive care units at 2 tertiary-care academic medical centers, over a 6-month period. Included were the patients who required > or = 24 hours of mechanical ventilation but did not have obstructive lung disease. Excluded were patients who had obstructive lung disease and/or who had undergone > 24 hours of mechanical ventilation outside the study intensive care units. Of the 206 patients included, 74 (36%) were prescribed inhaled bronchodilators without clear indication. Sixty-five of those 74 patients received both albuterol and ipratropium bromide, usually within the first 3 days of intubation (58 patients). Patients prescribed bronchodilators were more hypoxemic; their mean P(aO(2))/F(IO(2)) ratio was lower (188 mm Hg versus 238 mm Hg, p = 0.004), and they were more likely to have pneumonia (53% vs 33%, p = 0.007). The mean extra cost for bronchodilators was 449.35 dollars per patient. Between the group that did receive bronchodilators and the group that did not, there was no significant difference in the incidence of ventilator-associated pneumonia, tracheostomy, or mortality. The incidence of tachyarrhythmias was similar (15% vs 22%, p = 0.25). A substantial proportion of mechanically ventilated patients without obstructive lung disease received inhaled bronchodilators.
    Respiratory care 02/2007; 52(2):154-8. · 1.84 Impact Factor

Publication Stats

132 Citations
63.11 Total Impact Points


  • 2009-2014
    • Yale-New Haven Hospital
      • Department of Laboratory Medicine
      New Haven, Connecticut, United States
  • 2008-2011
    • Yale University
      • Section of Pulmonary and Critical Care Medicine
      New Haven, Connecticut, United States