Siu Yin Lee

Lands Department of The Government of the Hong Kong Special Administrative Region, Hong Kong, Hong Kong

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Publications (15)48.09 Total impact

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    ABSTRACT: Background and AimsLarge cohort studies on smoking and mortality in older people are scarce and few studies examined smokers aged 85+ years separately. We estimated the risks of all-cause and cause specific mortality due to smoking in an elderly Chinese cohort in Hong Kong.DesignA population-based prospective cohort of 65,510 Chinese enrolled from 1998 to 2001 and followed until May 2012.SettingAll 18 Elderly Health Service centres in Hong Kong, China.ParticipantsOlder people aged 65+ yearsMeasurementsSelf-reported smoking status was assessed at baseline interview and categorized as never, former and current smokers.FindingsCompared with never smokers, after adjustment for sex, age, education, social security assistance, housing type, monthly expenditure, alcohol use, depressive symptoms and health status, the hazards ratio (HR) for current smokers was 1.89 (95% confidence interval (CI) 1.81-1.98) for all participants aged 65+ years at baseline, corresponding to an attributable fraction (AF) of about 50%, which is based on AF = (HR-1)/HR. As the effect of smoking varied with age (P for age interaction <0.001), subgroup analysis by age group showed that the adjusted HR for current smokers aged 65-84 years was 1.93 (1.84-2.03), and for 85+ years was 1.29 (1.05-1.58). All the risk estimates did not vary by sex (P for sex interaction ranged 0.74-0.89).Conclusions In Hong Kong, the risk of death from smoking appears to be the same for Chinese women as it is for men. Half of all deaths in Chinese smokers aged 65 years and over and a quarter of all deaths in Chinese smokers aged 85 years and over are caused by smoking-attributable diseases.
    Addiction 10/2014; · 4.58 Impact Factor
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    ABSTRACT: Objectives In the West, self-rated health reliably predicts death, but conceptualizations of health and cause-composition of mortality may be contextually specific. Little is known as to how self-rated health predicts death in non-Western settings. Methods Multivariable Cox regression analysis was used to assess the adjusted associations of age-comparative and self-comparative self-rated health with death from all- and specific-causes using a population-based cohort of 66,820 Chinese (65 + years) enrolled from 1998 to 2001 at 18 Elderly Health Centers in Hong Kong, and followed until May 31, 2012. Results During an average of 10.9 years follow-up, 19,845 deaths occurred with 6336 from cancer. Worse age-comparative self-rated health, compared with better, was positively associated with death from all-causes (hazard ratio 1.68, 95% confidence interval 1.59, 1.77), cardiovascular disease (hazard ratio 1.83, 95% confidence interval 1.66, 2.02), stroke (hazard ratio 1.93, 95% confidence interval 1.63, 2.29), ischemic heart disease (hazard ratio 1.77, 95% confidence interval 1.51, 2.08), cancer (hazard ratio 1.17, 95% confidence interval 1.06, 1.30) and respiratory disease (hazard ratio 2.25, 95% confidence interval 2.01, 2.52), adjusted for age and sex. Self-comparative self-rated health was not associated with higher mortality. Conclusion Age-comparative self-rated health predicted death in older people from a non-Western setting although the association was less marked than in Western settings.
    Preventive medicine. 07/2014; 67(October 2014):112-118.
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    ABSTRACT: Selective C(α)–C(β) bond activation of aliphatic ethers.
    Journal of Organometallic Chemistry 07/2014; 762:88–93. · 2.00 Impact Factor
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    ABSTRACT: In Western countries, diabetes mellitus is positively associated with death from all- and specific-causes including cancer, cardiovascular and respiratory diseases. In a Chinese setting with a different disease pattern: high diabetes rates in a relatively non-obese population with low ischemic heart disease (IHD) rates where diabetes is positively associated with IHD, we examined the association of self-reported diabetes with death among older people. Multivariable Cox regression analysis was used in a population-based prospective cohort of 66,820 Chinese (65+ years) enrolled from July 1998 to December 2001 at Elderly Health Centers of the Hong Kong Government Department of Health, followed until May 31, 2012. During 10.9years of follow-up, 19,845 deaths occurred. Self-reported diabetes was associated with death from all-causes (hazard ratio (HR)=1.56, 95% confidence interval (CI) 1.51, 1.62), cardiovascular disease (HR=1.84, 95% CI 1.72, 1.96), cancer (HR=1.11, 95% CI 1.03 to 1.20), liver cancer (HR=1.38, 95% CI 1.13 to 1.69) and stomach cancer (HR=1.38, 95% CI 1.03 to 1.85), adjusted for age, sex, socio-economic position, alcohol use, smoking, exercise and body mass index. Such a pattern of associations suggests further investigation into the drivers of diabetes is required in this and similar populations.
    Preventive Medicine 04/2014; · 3.50 Impact Factor
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    ABSTRACT: In Western settings, moderate drinking is negatively associated with respiratory disease. However, moderate drinking is socially patterned, making this association vulnerable to contextual biases. Evidence from other contexts where the typical drinking pattern is different may clarify such observations. Multivariable Cox regression analysis was used to assess the adjusted associations of alcohol use with death from respiratory disease using a population-based prospective cohort of 66,820 Chinese aged ≥65years enrolled from July 1998 to December 2001 at all the 18 Elderly Health Centers of the Hong Kong Government Department of Health and followed till May 30, 2012. During ten-year follow-up, 4065 deaths from respiratory disease occurred. Most current drinkers were occasional drinkers (<1day/week). Both moderate and occasional drinking (<1day/week) were associated with a lower risk of death from respiratory disease, but the point estimates and pattern of associations were similar between these two types of drinkers. The typical drinking pattern, i.e. occasional drinking (<1day/week), which is unlikely to have any biological effect, was similarly associated with a lower risk of respiratory disease as moderate alcohol use, suggesting the attributes of being a typical drinker may be protective.
    Preventive Medicine 09/2013; · 3.50 Impact Factor
  • Siu Yin Lee, Kin Shing Chan
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    ABSTRACT: Photocatalytic carbon–carbon σ-bond oxidation of unstrained ketones by water using rhodium(III) porphyrin catalyst was accomplished. The catalysis yielded the corresponding one-carbon-less carbonyl compound and H2 with up to 30 turnovers in both aliphatic and cyclic ketones with α substituents. No carbon loss was observed in aromatic ketone. Mechanistic studies suggest that (Ph3P)RhIII(ttp)OH (ttp = tetratolylporphyrinato dianion) is the key intermediate in the carbon–carbon σ-bond anaerobic oxidation.
    Organometallics 09/2013; 32(19):5391–5401. · 4.15 Impact Factor
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    ABSTRACT: In observational studies of Western populations, moderate alcohol use is usually associated with lower cancer mortality rates. However, moderate alcohol use (regular drinking of moderate amounts) is socially patterned. Evidence from other contexts can clarify such observations. We examined the association of moderate alcohol use with death from cancer in older Chinese adults from a developed non-Western setting, where occasional alcohol drinking (less than once per week of small amounts) is typical. Multivariable Cox regression analysis was used to assess the adjusted associations of alcohol use with death from cancer using a population-based prospective cohort of 66 820 Chinese aged ≥65 years enrolled from July 1998 to December 2001 at all the 18 Elderly Health Centres of the Hong Kong Government Department of Health, and followed till 30 May 2012. After follow-up for about 10.5 years, 6335 cancer deaths were identified. Most current alcohol users were social drinkers (<1/week). Moderate drinkers had a similar risk of death from non-oesophageal cancer as never drinkers, but a higher risk of oesophageal cancer, adjusted for age, sex, socioeconomic position, lifestyle and health status. Social drinking (<1/week) was associated with a lower risk of death from non-oesophageal cancer, but not from oesophageal cancer. In a non-Western setting, no association of moderate alcohol use with death from cancer was found. Occasional social drinking (<1/week) was associated with a lower risk of cancer, suggesting that moderate alcohol use is not protective, but in any setting the attributes of being a typical drinker may be.
    Journal of epidemiology and community health 08/2013; · 3.04 Impact Factor
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    ABSTRACT: BACKGROUND AND PURPOSE: Hemorrhagic stroke is more common in non-Western settings and does not always share risk factors with other cardiovascular diseases. The association of smoking with hemorrhagic stroke subtypes has not been established. We examined the association of cigarette smoking with hemorrhagic stroke, by subtype (intracerebral hemorrhage and subarachnoid hemorrhage), in a large cohort of older Chinese from Hong Kong. METHODS: Multivariable Cox regression analysis was used to assess the adjusted associations of smoking at baseline with death from hemorrhagic stroke and its subtypes, using a population-based prospective cohort of 66 820 Chinese aged >65 years enrolled from July 1998 to December 2001 at all the 18 Elderly Health Centers of the Hong Kong Government Department of Health and followed until May 31, 2012. RESULTS: After follow-up for an average of 10.9 years (SD=3.1), 648 deaths from hemorrhagic stroke had occurred, of which 530 (82%) were intracerebral hemorrhage. Current smoking was associated with a higher risk of hemorrhagic stroke (hazard ratio, 2.19; 95% confidence interval, 1.49-3.22), intracerebral hemorrhage (1.94; 1.25-3.01), and subarachnoid hemorrhage (3.58; 1.62-7.94), adjusted for age, sex, education, public assistance, housing type, monthly expenditure, alcohol use, and exercise. Further adjustment for hypertension and body mass index slightly changed the estimates. CONCLUSIONS: Smoking is strongly associated with hemorrhagic stroke mortality, particularly for subarachnoid hemorrhage.
    Stroke 05/2013; · 6.16 Impact Factor
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    ABSTRACT: Rhodium(III) porphyrin β-hydroxyethyl, RhIII(ttp)CH2CH2OH (ttp = 5,10,15,20-tetratolylporphyrinato dianion), was found to serve as a precursor of the highly reactive RhIII(ttp)OH for the C(CO)–C(α) bond activation (CCA) of ketones under mild and aerobic conditions of 25–50 °C.
    Organometallics 12/2012; 32(1):151–156. · 4.15 Impact Factor
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    ABSTRACT: Selective aliphatic carbon(α)–carbon(β) bond activation of ethers by (5,10,15,20-tetramesitylporphyrinato)rhodium(II) (Rh(tmp) (1)) was achieved at room temperature to yield corresponding rhodium porphyrin alkyls and the functionalized esters. Rh(tmp)OH was the proposed intermediate responsible for cleaving the C(α)–C(β) bond. The reaction is general for both straight- and branch-chain ethers.
    Organometallics 06/2011; 30(14):3691–3693. · 4.15 Impact Factor
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    ABSTRACT: Highly reactive rhodium(III) porphyrin hydroxides were formed from the ligand substitution of rhodium porphyrin halides in benzene and were rapidly reduced to rhodium(II) porphyrins and hydrogen peroxide. Thus hydroxide acted as the reducing agent. Oxidative addition of rhodium(II) porphyrin with hydrogen peroxide proceeded rapidly at room temperature to give back rhodium(III) porphyrin hydroxides. Rhodium(II) porphyrins and H2O2 therefore were thermally reversible with rhodium porphyrin hydroxides.
    Organometallics 05/2011; 30(10):2633–2635. · 4.15 Impact Factor
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    ABSTRACT: Reaction of hydrido[5,10,15,20-tetrakis(p-tolyl)porphyrinato]iridium(III) (Ir(ttp)H) (1) with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) (2) at room temperature gave a 90% yield of the unsupported iridium(II) porphyrin dimer, Ir(II)(2)(ttp)(2) (3). Kinetic measurements revealed that the oxidation followed overall second-order kinetics: rate = k[Ir(ttp)H][TEMPO], k(25 °C) = 6.65 × 10(-4) M(-1). The entropy of activation (ΔS(‡) = -25.3 ± 2.5 cal mol(-1) K(-1)) and the kinetic isotope effect of 7.2 supported a bimolecular associative mechanism in the rate-determining hydrogen atom transfer from Ir(ttp)H to TEMPO.
    Inorganic Chemistry 10/2010; 49(20):9636-40. · 4.59 Impact Factor
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    ABSTRACT: Ir(ttp)Cl(CO) (1a; ttp = 5,10,15,20-tetrakis(p-tolyl)porphyrinato dianion) was found to cleave the C−O bond of CH3OH at 200 °C to give Ir(ttp)CH3 (3a). Addition of KOH promoted the reaction rate and gave a higher yield of Ir(ttp)CH3 in 70% yield in 1 day. Mechanistic studies suggest that, in the absence of KOH, Ir(ttp)Cl(CO) reacts with CH3OH initially to give Ir(ttp)OCH3, which then undergoes β-hydride elimination to produce Ir(ttp)H (4a). Ir(ttp)H further reacts slowly to cleave the C−O bond of CH3OH, likely via σ-bond metathesis, to give Ir(ttp)CH3. In the presence of KOH, Ir(ttp)Cl(CO) initially reacts with KOH more rapidly to give Ir(ttp)OH, which then cleaves the O−H bond of CH3OH by metathesis to give Ir(ttp)OCH3. Ir(ttp)OCH3 further isomerizes via β-hydride elimination/reinsertion to give Ir(ttp)CH2OH and concurrently undergoes base-assisted β-proton elimination to give Ir(ttp)−K+ (5a). Ir(ttp)CH2OH subsequently condenses with CH3OH to form Ir(ttp)CH2OCH3 (2). Finally, Ir(ttp)−K+ cleaves the C−O bond in CH3OH, most probably via nucleophilic substitution, to give Ir(ttp)CH3. Ir(ttp)CH2OCH3 also serves as the precursor of Ir(ttp)−K+ as it undergoes nucleophilic substitution by KOH to give Ir(ttp)−K+.
    Organometallics. 02/2010; 29(6).
  • Kin Shing Chan, Xin Zhu Li, Siu Yin Lee
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    ABSTRACT: Rh(tmp) underwent Ph3P-enhanced aliphatic carbon−carbon bond activation with various nitroxides. (Ph3P)Rh(tmp), rapidly formed from Rh(tmp) and Ph3P, enhanced the rate, selectivity, and yield in comparison to Rh(tmp). From kinetic studies, the rate of reaction showed a first-order dependence on both Rh(tmp) and TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidine-1-oxyl) and saturation kinetics on Ph3P. The rate enhancement of (Ph3P)Rh(tmp) over Rh(tmp) was estimated to be about 11 at 70 °C.
    Organometallics 01/2010; 29(13):2850-2856. · 4.15 Impact Factor
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    ABSTRACT: Rh(ttp)Cl (1a) (ttp = 5,10,15,20-tetrakistolylporphyrinato dianion) was found to react with methanol at a high temperature of 150 °C in the presence of inorganic bases to give a high yield of Rh(ttp)CH3 (2a), up to 87%. Rh(ttp)H (1d) is suggested to be the key intermediate for the carbon−oxygen bond cleavage.
    Organometallics. 07/2009; 28(14).

Publication Stats

2 Citations
48.09 Total Impact Points

Institutions

  • 2014
    • Lands Department of The Government of the Hong Kong Special Administrative Region
      Hong Kong, Hong Kong
  • 2013–2014
    • Hong Kong SAR Government
      Hong Kong, Hong Kong
    • The University of Hong Kong
      • Department of Community Medicine
      Hong Kong, Hong Kong
  • 2010–2014
    • The Chinese University of Hong Kong
      Hong Kong, Hong Kong