[Show abstract][Hide abstract] ABSTRACT: Fibrous bone lesions are classified as ossifying fibroma, fibrous dysplasia, and cement-osseous dysplasia. Ossifying fibroma is further classified into juvenile psammomatoid ossifying fibroma (JPOF) and juvenile trabecular ossifying fibroma (JTOF). Although JPOF is histologically benign, it is locally invasive, which is very rare for a benign tumor. Here, we report a rare case of left ethmoid sinus JPOF that underwent endoscopic tumorectomy. The patient was a 7-years and 5-month-old boy, who developed left ophthalmocele 2 months before he visited the ophthalmology department. MRI of orbits revealed a solid tumor within the left ethmoid sinus, so the patient was referred to us. The tumor was 38 × 24mm in size, and exhibited high-intensity signal on T2-weighted image and relatively high intensity signal on T1-weighted image. Plain CT showed that the tumor had relatively high-density areas inside, compressed surrounding bone, and displaced the left eye-orbit lateral wall with partial wall defects. The patient did not have visual field defect or impairment of vision. He underwent endoscopic tumorectomy with an inferior nasal and parasinus approach under general anesthesia. The tumor was elastic and hard, surrounded by an ossifying septal structure, and the interior of the tumor was hemorrhagic. Partial defect of the medial orbital wall was found and the bleeding amount was significant. Thus, we only removed the ossifying septum of the tumor at the middle nasal meatus for diagnostic purposes and left the septum of the tumor at the orbit side. Pathological examination revealed JPOF.
[Show abstract][Hide abstract] ABSTRACT: Of the patients seen for cervical neurinomas at our department between April 2005 and March 2014, 31 underwent intercapsular resection. Of them, we investigated 10 in whom the condition originated in the vagus nerve. 3 patients showed postoperative neurological deficit. One patient improved within 3 months, but the others did not improve. Hoarseness, dysphagia and coughing attack may be caused in cases by a neurinoma operation in the vagus nerve, which may greatly affect a patient's occupation and quality of life. Before operation, informed consent must be obtained, and relevant surgical experience should be acquired in addition to taking any disadvantages into account.
[Show abstract][Hide abstract] ABSTRACT: Aims:
In recent years, there has been an increase in patients with arteriosclerosis and the risk of lifestyle-related diseases. However, the pathogenesis and medication of atherosclerosis have not been elucidated. We developed a rat model of lifestyle-related diseases by feeding a high-fat diet and 30% sucrose solution (HFDS) to spontaneously hypertensive hyperlipidemic rats (SHHR) and reported that this model is a useful model of early atherosclerosis. In order to elucidate the pathogenesis of early atherosclerosis, we searched for atherosclerosis-related genes by microarray analysis using the aortic arch rat model of lifestyle-related diseases.
Four-month-old male Sprague-Dawley rats and SHHR were each divided into two normal diet (ND) groups and two HFDS groups. After a four-month treatment, the expression of mRNA in the aortic arch was detected using the oligo DNA microarray one-color method and quantified using real-time PCR.
In this study, we detected 39 genes in microarray analysis. Esm1, Retnlb Mkks, and Grem2 showed particularly marked changes in gene expression in the SHHR-HFDS group. Compared with the SD-ND group, the SHHR-HFDS group had an increase in Mkks gene expression of about 26-fold and an approximately 22-fold increase in the expression of Grem2. Similarly, the expression of Esm1 increased by about 12-fold and that of Retnlg by about 10-fold as shown by quantitative real-time PCR.
This study suggested that these four genes might be important in early atherosclerosis development.
Life sciences 08/2013; 93(15). DOI:10.1016/j.lfs.2013.08.010 · 2.70 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Laryngeal cancer is one of the most common types of head and neck cancer. Numerous studies have reported treatment outcomes, and therapeutic approaches and results are generally well established. However, the widespread use of concurrent chemoradiation therapy(CCRT)has led to differences among hospitals in laryngeal preservation rates in patients with T2 and T3 tumors. CCRT is the mainstay of treatment for laryngeal cancer in our department, given our goals of achieving organ and functional preservation, as well as radical cure. Our regimen for CCRT is comprised of chemotherapy with S-1 plus nedaplatin, concurrently with radiation therapy(SN therapy). We report outcomes obtained from 60 patients with laryngeal cancer who received first-line treatment in our department from April 2005 through March 2010. Cumulative survival rates according to disease stage were as follows: Stage I, 100%; Stage II, 96. 2%; Stage III, 83. 3%; and Stage IV, 48. 8%. The complete response rate after SN therapy was 84. 3%. After excluding patients with T4 tumors, the laryngeal preservation rate was 85. 7%.
Gan to kagaku ryoho. Cancer & chemotherapy 08/2011; 38(8):1301-5.
[Show abstract][Hide abstract] ABSTRACT: A 68-year-old man was admitted with hoarseness. Laryngofiberscopy showed a tumor that obstructed the posterior hypopharyngeal wall and the larynx, and biopsy revealed well-differentiated squamous cell carcinoma. CT demonstrated bilateral cervical lymph node metastases. The patient was diagnosed as having hypopharyngeal cancer(T4N2cM0)and was treated with concurrent S-1, nedaplatin and radiotherapy(hereafter referred to as SN therapy). CT and endoscopy after primary treatment showed disappearance of the tumor, and the treatment outcome was assessed as complete response(CR). Currently, the patient is being treated with S-1 as adjuvant chemotherapy in the outpatient setting, and no recurrence or metastasis has been observed. These results suggest that SN therapy was effective for advanced hypopharyngeal cancer from the viewpoint of both curative treatment and organ and function preservation.
Gan to kagaku ryoho. Cancer & chemotherapy 04/2011; 38(4):631-3.
[Show abstract][Hide abstract] ABSTRACT: We reported the efficacy of concurrent chemoradiotherapy(CCRT)for cervical lymph node metastasis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma. The subjects were 17 patients with oropharyngeal or hypopharyngeal cancer with cervical lymph node metastasis, who underwent CCRT treatment between January 2005 and December 2009. The proportion of patients showing a complete response(CR)was 64. 7%; however, if patients without any residual viable cancer cells in the specimens obtained by neck dissection were also defined as CR, then, 82. 4% achieved CR. Thus, CCRT showed good efficacy without the need for planned neck dissection(PND). The limited recurrence cases and absence of serious complications associated with neck dissection after CCRT suggested that PND is not necessarily required. However, since assessment of cervical lymph nodes after CCRT is difficult, it would be desirable to develop a reliable examination and to study the most suitable examination for detecting the presence/absence of cervical lymph node metastasis.
Gan to kagaku ryoho. Cancer & chemotherapy 04/2011; 38(4):571-5.
[Show abstract][Hide abstract] ABSTRACT: Desmoids, although pathologically benign, are called "locally malignant tumors", due to their infiltrative growth and tendency to recur locally. They are roughly classified as abdominal (90%) or extraabdominal (10%), with 12-20% of extra abdominal occurring on the head and neck. We report a case of extra abdominal frontal neck desmoid. A 47-year-old woman was seen for a frontal neck. Unable to pathologically diagnose the tumor preoperatively, we suspected a schwannoma, leiomyoma, or solitary fibrous tumor. After two total resections and immediate local recurrence, we suggested that she undergo neck radiotherapy. No recurrence has occurred in the 6 months since postoperative 50 Gy radiation. Neck tumor occurrence should thus suggest the possibility of desmoids.
[Show abstract][Hide abstract] ABSTRACT: Many reports have been published on the treatment for hypopharyngeal cancer, and the treatment modalities and results have become uniform to some extent. More specifically, reconstruction by means of free jejunal grafts has become widespread, and the results of surgical treatments have stabilized. On the other hand concurrent chemoradiotherapy has been widely performed, and the results from the standpoint of organ and function preservation have revealed the various differences between institutions. In our department, we have been using concurrent chemoradiotherapy for advanced cancer with a view to organ and function preservation. In this article, we report 6 cases with hypopharyngeal cancer treated by concurrent chemoradiotherapy with S-1 plus nedaplatin(SN therapy)in our department between January 2005 and December 2008. The complete response rate after SN therapy was 83. 3%, and the laryngeal preservation rate was 100%.
Gan to kagaku ryoho. Cancer & chemotherapy 02/2011; 38(2):233-5.
[Show abstract][Hide abstract] ABSTRACT: A primary head and neck adenocarcinoma is a comparatively rare disease, and surgical resection has been the first choice for its treatment. In the present study, we performed chemotherapy with weekly administration of docetaxel in 3 cases with unresectable or recurrent adenocarcinoma of the head and neck on an outpatient basis, resulting in long-term maintenance of the patients' QOL. Each case had submandibular gland carcinoma, parotid gland carcinoma, or parathyroid gland carcinoma. Their observation period was 42, 76, or 87 months, respectively. Docetaxel was administered for 18, 19, or 28 courses, respectively. No adverse events of grade 3 or higher were observed. The present results might suggest that it is possible to treat patients with adenocarcinoma in the head and neck without decreasing patients' QOL.
Gan to kagaku ryoho. Cancer & chemotherapy 12/2010; 37(13):2897-900.
[Show abstract][Hide abstract] ABSTRACT: Various treatments for oropharynx cancer included radiotherapy, arterial injection chemotherapy (as well as combined chemoradiotherapy), combined concurrent chemoradiotherapy, and surgical resection and reconstruction. There are also treatment differences among facilities. Our department has been providing a treatment modality for head and neck malignancies with the aims of functional and morphological preservation with a high cure rate. We herein report the treatment efficacy in 7 cases of oropharynx cancer (6 cases on lateral wall and 1 case on superior wall)treated with S-1, nedaplatin and radiotherapy (SN therapy) at our department between April 2006 and December 2006. The total of 7 cases included 1 case of T1N1M0, 1 of T2N0M0, 2 of T2N2bM0, 1 of T2N2cM0, 1 of T3N2cM0, and 1 case of T4N2cM0. The patients were all male and their ages ranged from 57 to 76 years old, with the average age of 68.4 years. Six of the 7 cases are surviving without cancer through treatment and their functions and morphologies have been preserved. In the 1 case of T4N2cM0, the tumor did not disappear and the patient expired due to the original lesion. Although SN therapy supposedly enables functional and morphological preservation, it is necessary to increase the number of cases and examine the efficacy of SN therapy for oropharynx cancer for functional and morphological preservation and the survival rate.
Gan to kagaku ryoho. Cancer & chemotherapy 08/2010; 37(8):1535-7.
[Show abstract][Hide abstract] ABSTRACT: It is not rare to observe multiple cancers in cases of head and neck carcinoma. Such cancers are important factors for deciding the therapeutic strategy. Complications of esophageal cancer are particularly frequent in cases of hypopharyngeal cancer in comparison to other head and neck tumors. At our department, for organ and functional preservation, and radical cure, we have used simultaneous therapy instead of separate therapy for head and neck tumors and esophageal cancer. We have been implementing concurrent S-1, nedaplatin/radiation therapy (hereinafter called SN therapy) for cases of advanced cancer of the head and neck, and we applied the same therapy for cases of head and neck carcinoma with esophageal cancer. The subjects comprised 5 cases of head and neck tumors complicated by esophageal cancer for which therapy was conducted at our department between April 2005 and March 2009. The histologic type was squamous cell carcinoma in all of the cases. There were 2 cases of laryngeal cancer (T3N2cM0, T3N0M0) and 3 cases of hypopharyngeal cancer (T3N2cM0, T4N2cM0, T3N2bM0). As a result, 3 out of the 5 cases have remained cancer-free, and the average observation period was 29. 3 months. One case expired due to an unrelated cause as a result of cardiac disease, while in the remaining case, the tumor did not disappear and the patient died due to the disease. It is necessary to continue examining the survival rate by increasing the number of cases.
Gan to kagaku ryoho. Cancer & chemotherapy 07/2010; 37(7):1349-52.
[Show abstract][Hide abstract] ABSTRACT: Low-grade myofibroblastic sarcoma (LGMS) represents a distinct atypical myofibroblastic tumor that occurs at several sites, primarily within the head and neck regions. A painless, enlarged mass is the most common clinical presentation, but a definitive diagnosis requires both histopathological and immunohistochemical analyses. Histologically, LGMS commonly presents as a cellular lesion composed of spindle-shaped tumor cells arranged primarily in fascicles with a diffusely infiltrative pattern. Immunohistochemically, LGMS shows positive staining for at least one myogenic marker, such as desmin or muscle actin. Here we report a case of LGMS in the base of the tongue. Our case showed positive immunostaining for desmin and vimentin, and was thus diagnosed as LGMS. The patient received surgery, but no chemotherapy or radiotherapy, and was completely without evidence of the disease 38 months after the surgery.