Sarah A Jackson

Publications (2)29.53 Total impact

• Article: Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma.

  Timothy Best, Dalin Li, Andrew D Skol, Tomas Kirchhoff, Sarah A Jackson, Yutaka Yasui, Smita Bhatia, Louise C Strong, Susan M Domchek, Katherine L Nathanson, Olufunmilayo I Olopade, R Stephanie Huang, Thomas M Mack, David V Conti, Kenneth Offit, Wendy Cozen, Leslie L Robison, Kenan Onel
  [show abstract] [hide abstract]
  ABSTRACT: Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy-induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.
  Nature medicine 01/2011; 17(8):941-3. · 27.14 Impact Factor
• Article: Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.

  Jane E Churpek, Jacqueline S Garcia, Jozef Madzo, Sarah A Jackson, Kenan Onel, Lucy A Godley
  Leukemia & lymphoma 10/2010; 51(10):1931-5. · 2.40 Impact Factor