Santiago Tofé Povedano

Publications (2)1.83 Total impact

• Article: [Routine performance of thyroid ultrasound and fine-needle aspiration biopsy in the setting of a high-resolution endocrinology practice].

  Santiago Tofé Povedano, Iñaki Argüelles Jiménez, Honorato García Fernández, Julia Quevedo Juanals, Sergio Díaz Medina, Guillermo Serra Soler, Bartolomé Burguera González, Mercedes Codina Marcet, Elena Mena Ribas, Juan Ramón Urgeles Planella, Vicente Pereg Macazaga
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  ABSTRACT: Fine-needle aspiration biopsy (FNAB) is considered the reference diagnostic procedure for thyroid nodules. Routine performance of thyroid ultrasound and ultrasound-guided FNAB by endocrinologists allows a more efficient approach in the setting of a high-resolution practice, thus reducing costs and the time elapsed until diagnosis. We present our initial results of this procedure 2 years after its introduction, with a total of 286 biopsies performed. After a progressive learning curve over time and according to the endocrinologists' previous experience, 72.72% samples were considered satisfactory for diagnosis. Greater difficulty was observed in obtaining optimal cytological specimens in smaller nodules. In conclusion, we have successfully incorporated thyroid ultrasound and ultrasound-guided FNAB into routine endocrine practice. Routine performance of thyroid ultrasound in endocrine practice will considerably aid the management of nodular thyroid disease.
  Endocrinología y Nutrición 02/2010; 57(2):43-8.
• Article: 24-hour and nighttime blood pressures in type 2 diabetic hypertensive patients following morning or evening administration of olmesartan.

  Santiago Tofé Povedano, Bernardo García De La Villa
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  ABSTRACT: Ambulatory blood pressure monitoring (ABPM) allows determining of the nocturnal blood pressure fall (NBPF). An NBPF below 10% (nondipper pattern) has been related to increased cardiovascular risk, and it is a common finding in type 2 diabetic hypertensive patients. The authors evaluated the impact on 24-hour blood pressure, NBPF, and albuminuria of olmesartan 40 mg, administered in a morning- vs a nocturnal-based dosing scheme, in type 2 diabetic patients with newly diagnosed hypertension. Using a crossover design, 40 patients (42.1% men) received olmesartan 40 mg once daily at wake up or bedtime for 8 weeks. Patients underwent 24-hour ABPM at baseline and at weeks 8 and 16, and albumin to creatinine ratio was measured at baseline and 8 weeks. Night systolic blood pressure (BP) (P=.007) and mean BP (P=.012) were significantly reduced following the bedtime dose, compared with morning dosing. Night BP fall (%) was significantly reduced by bedtime dosing, compared with morning dosing (P=.0001). No differences were seen for urinary albumin excretion between both arms at week 8. Without affecting 24-hour BP control, night dosing of olmesartan increases nocturnal BP fall significantly more than conventional morning dosing, increasing the number of dipper diabetic hypertensive patients.
  Journal of Clinical Hypertension 09/2009; 11(8):426-31. · 1.83 Impact Factor