Sanjib Bhattacharya

Publications (37)11.76 Total impact

• Article: Trichosanthes dioica fruit ameliorates experimentally induced arsenic toxicity in male albino rats through the alleviation of oxidative stress.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: The present work was focused to evaluate the ameliorative property of aqueous extract of Trichosanthes dioica fruit (AQ T. dioica fruit) against arsenic-induced toxicity in male Wistar albino rats. AQ T. dioica fruit was administered orally to rats at 50 and 100 mg/kg body weight for 20 consecutive days prior to oral administration of sodium arsenite (10 mg/kg) for 10 days. Then the rats were sacrificed for the evaluation of body weights, organ weights, hematological profile, serum biochemical profile, and hepatic and renal antioxidative parameters viz. lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and DNA fragmentation. Pretreatment with AQ T. dioica fruit at both doses markedly and significantly normalized body weights, organ weights, hematological profiles, and serum biochemical profile in arsenic-treated animals. Further, AQ T. dioica fruit pretreatment significantly modulated all the aforesaid hepatic and renal biochemical perturbations and reduced DNA fragmentation in arsenic-intoxicated rats. Therefore, from the present findings, it can be concluded that T. dioica fruit possessed remarkable value in amelioration of arsenic-induced hepatic and renal toxicity, mediated by alleviation of arsenic-induced oxidative stress by multiple mechanisms in male albino rats.
  Biological trace element research 03/2012; 148(2):232-41. · 1.92 Impact Factor
• Article: Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: The present study evaluated the ameliorative potential of hydroalcoholic extract of Trichosanthes dioica root (TDA) against arsenic induced toxicity in male albino rats. TDA (5 and 10mg/kg) was administered orally to rats for 20 consecutive days before oral administration of sodium arsenite (10mg/kg) for 8 days. Then the body weights, organ weights, haematological profiles, serum biochemical profile; hepatic and renal antioxidative parameters viz. lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase and DNA fragmentation were evaluated. Pretreatment with TDA markedly and significantly normalized body weights, organ weights, haematological profiles, serum biochemical profile and significantly modulated all the hepatic and renal biochemical parameters and reduced DNA fragmentation in arsenic intoxicated rats. The present findings conclude that T. dioica root possessed remarkable ameliorative effect against arsenic induced organ toxicity in male albino rats mediated by alleviation of arsenic induced oxidative stress by multiple mechanisms.
  Environmental toxicology and pharmacology. 02/2012; 33(3):394-402.
• Article: Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber grown in the Indian subcontinent. This study evaluated the anti-nociceptive and anti-inflammatory effects of triterpenoid-enriched extract of T. dioica root (CETD) in rodents at the doses of 50 and 100 mg kg(-1) body weight po. Anti-nociceptive activity was evaluated by acetic acid-induced writhing and tail flick methods in Swiss albino mice. CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats. In writhing test, CETD dose dependently and significantly inhibited writhes; in tail flick test, CETD demonstrated significant increase in reaction time (after 60 and 120 min). In all the anti-inflammatory models, CETD exhibited promising anti-inflammatory activity in a dose-dependent manner. Therefore, T. dioica root afforded remarkable anti-nociceptive and anti-inflammatory protections in the tested rodent models.
  Natural product research 01/2012; · 1.01 Impact Factor
• Article: The triterpenoid fraction from Trichosanthes dioica root exhibits antiproliferative activity against Ehrlich ascites carcinoma in albino mice: involvement of possible antioxidant role.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: The present study assessed the triterpenoid fraction from T dioica root (CETD) for antiproliferative effect and antioxidant influence against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, CETD was administered at 2 and 4 mg/ kg body weight daily for 9 consecutive days. On the 10th day, half of the mice were sacrificed for estimation of tumor proliferation, haematological, and hepatic antioxidative parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase(SOD)and catalase (CAT); the rest were kept alive for assessment of survival parameters. The antiproliferative effect of CETD was assessed by evaluating tumor weight, tumor volume, packed cell volume, viable and non-viable tumor cell counts, mean survival time and percentage increase in life span of EAC-bearing mice. CETD exhibited dose dependent and significant (p < 0.001) decreases in tumor weight, tumor volume, packed cell volume and viable cell count and extended the life span of EAC-bearing mice. Hematological profiles were significantly (p < 0.001) normalized in CETD treated mice as compared to EAC control. CETD treatment significantly (p < 0.001) modulated the aforementioned hepatic antioxidative parameters as compared to EAC control. The present study demonstrated that CETD possessed promising antiproliferative efficacy against EAC in mice, plausibly mediated by alleviation of oxidative stress by multiple mechanisms.
  Journal of Experimental Therapeutics and Oncology 01/2012; 9(4):281-90.
• Article: Chemopreventive Property of Trichosanthes dioica Root Against 3-Methylcholanthrene-induced Carcinogenesis in Albino Mice.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: This work reports the chemopreventive property of hydroalcoholic extract of the Trichosanthes dioica root (TDA) against 3-methylcholanthrene (3-MC)-induced carcinogenesis in Swiss albino mice. TDA was administered orally at 2 and 4 mg/kg for 45 days after 24 hours of a single subcutaneous administration of 3-MC (200 µg) in mice. The mice were observed for 15 weeks to record tumor incidence (fibrosarcoma) and survival. After 15 weeks the mice were killed for the evaluation of hematological profiles and hepatic biochemical parameters viz lipid peroxidation, reduced glutathione, glutathione-S-transferase, superoxide dismutase, and catalase. TDA treatment markedly reduced tumor incidence and prolonged the life span of sarcoma-bearing mice compared with 3-MC control mice. Hematological profiles of TDA-treated mice were restored significantly to normal levels. TDA treatment significantly modulated the liver biochemical parameters compared with 3-MC control. Therefore, TDA possesses remarkable cancer chemopreventive efficacy plausibly mediated by multiple mechanisms in Swiss albino mice.
  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 01/2012; 31(2):109-119.
• Article: Trichosanthes dioica root extract induces tumor proliferation and attenuation of antioxidant system in albino mice bearing Ehrlich ascites carcinoma.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber grown widely in the Indian subcontinent. The present study assessed the influence of treatment of hydroalcoholic extract of Trichosanthes dioica root (TDA) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice with effects on antioxidant systems. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, TDA was administered at 25 and 50 mg/kg for 8 consecutive days. On the 9(th) day, half of the mice were sacrificed for estimation of tumor proliferation, hematological, and hepatic antioxidative parameters. The rest were kept for assessment of survival parameters. TDA exhibited dose dependent and significant increase in tumor weight, tumor volume, packed cell volume and viable cells and reduced non-viable cells and life span of EAC bearing animals. Hematological parameters were significantly worsened in TDA-treated mice. TDA treatment significantly aggravated the hepatic antioxidative parameters. The present study demonstrated that T. dioica root possessed tumor promoting activity in EAC bearing albino mice, plausibly mediated by attenuation of endogenous antioxidant systems.
  Interdisciplinary toxicology 12/2011; 4(4):184-90.
• Article: Antitumour activity of Terminalia arjuna leaf against Ehrlich ascites carcinoma in mice.

  Moulisha Biswas, Sanjib Bhattacharya, Ashoke K Ghosh, R B Suresh Kumar, Samit Bera, Malaya Gupta, Pallab K Haldar
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  ABSTRACT: Terminalia arjuna Roxb. (Combretaceae), commonly known as 'Arjuna', is a large tree occurring throughout the Indian peninsula. This study was undertaken to evaluate the methanol extract of T. arjuna leaf (META) for antitumour activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitonial inoculation of tumour (EAC) cells in mice, META was administered at 100 and 200 mg kg(-1) body weights for 9 consecutive days. On day 10, half of the mice were sacrificed and the rest kept alive for an assessment of the increase in life span. The antitumour effect of META was assessed by evaluating tumour volume, tumour weight, viable and non-viable tumour cell counts, median survival time and increase in life span of EAC-bearing hosts. Haematological profiles were estimated. META showed a significant (p<0.001) decrease in tumour volume, tumour weight and viable cell count, and also increased the life span of EAC-bearing mice. Haematological profiles were significantly (p<0.001) restored to normal levels in META-treated mice compared to the EAC control. Therefore, from this study, it can be concluded that T. arjuna leaf exhibited remarkable antitumour activity against EAC in Swiss mice.
  Natural product research 10/2011; 26(12):1141-4. · 1.01 Impact Factor
• Article: Antitumour effect of Diospyros cordifolia bark on Ehrlich ascites carcinoma-bearing Swiss albino mice.

  Sudipta Das, Sanjib Bhattacharya, Goutam Pramanik, Pallab Kanti Haldar
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  ABSTRACT: Diospyros cordifolia Roxb. (Ebenaceae), commonly known as Indian ebony, is used traditionally for several medicinal purposes. In this study, the methanol extract of D. cordifolia bark (MEDC) was evaluated for its antitumour effect against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumour (EAC) cells in mice, MEDC was administered intraperitoneally at 25 and 50 mg kg⁻¹ bodyweight for 9 consecutive days. On the 10th day, half of the mice were sacrificed to determine the tumour volume, viable and non-viable tumour cell counts, and rest were kept alive for the assessment of median survival time and increase in life span. Haematological profiles were also determined. MEDC exhibited a marked decrease in tumour growth parameters and increased the survival rate of EAC-bearing animals. MEDC normalised the haematological parameters as compared with the EAC control mice. Therefore, this study demonstrated that D. cordifolia bark possessed remarkable antitumour efficacy.
  Natural product research 10/2011; 26(17):1631-3. · 1.01 Impact Factor
• Article: Antitumor efficacy and amelioration of oxidative stress by Trichosanthes dioica root against Ehrlich ascites carcinoma in mice.

  Sanjib Bhattacharya, Angelene Prasanna, Piyali Majumdar, R B Suresh Kumar, Pallab K Haldar
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  ABSTRACT: Trichosanthes dioica Roxb. (Cucurbitaceae) is a dioecious climber, traditionally used in India for several medicinal purposes. The present study assessed the hydroalcoholic extract of T. dioica root (TDA) for antitumor effect and antioxidant influence against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, TDA was administered at 5 and 10 mg/kg body weight daily for 9 consecutive days. On the 10th day, half of the mice were sacrificed for estimation of tumor proliferation, hematological, and liver antioxidant parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT); and the rest were kept alive for assessment of increase in life span. The antitumor effect of TDA was assessed by evaluating tumor weight, tumor volume, packed cell volume, viable and non-viable tumor cell counts, median survival time and percentage increase in life span of EAC bearing mice. TDA exhibited dose dependent and significant (p < 0.001) decrease in tumor weight, tumor volume, packed cell volume and viable cell count and extended the life span of EAC bearing hosts. Hematological profiles were significantly (p < 0.001) restored near to normal in TDA treated mice as compared to EAC control. TDA treatment significantly (p < 0.001) modulated the aforesaid liver antioxidant parameters as compared to EAC control. The present study demonstrated that TDA possessed promising antitumor efficacy in mice, plausibly mediated by amelioration of oxidative stress by multiple mechanisms.
  Pharmaceutical Biology 09/2011; 49(9):927-35. · 0.88 Impact Factor
• Article: Trichosanthes dioica root possesses stimulant laxative activity in mice.

  Sanjib Bhattacharya, Pallab Kanti Haldar
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  ABSTRACT: Trichosanthes dioica Roxb. (Cucurbitaceae), named 'pointed gourd' in English, is a dioecious climber grown in India. This study was aimed at evaluating the laxative activity of the aqueous extract of T. dioica root (TDA) in Swiss albino mice. The laxative activity of TDA (100 and 200 mg kg(-1) body weight per os) was evaluated by assessing the excretory bowel activities in naive (non-constipated) and in drug (loperamide)-induced constipation in mice. Further, the gastrointestinal transit was measured in both naive and in constipated mice. Castor oil (0.5 mL/mouse per os) was used as the reference. TDA significantly and dose-dependently increased all the excretory bowel activities and gastrointestinal transit in both naive and constipated mice. TDA at 200 mg kg(-1) body weight was found to be the most active, causing diarrhoea in mice. Thus, T. dioica root demonstrated stimulant laxative activity in Swiss mice, validating its traditional usage in India.
  Natural product research 08/2011; 26(10):952-7. · 1.01 Impact Factor
• Source

  Available from: Goutam Pramanik

  Article: Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats.

  Sudipta Das, Sanjib Bhattacharya, Angelene Prasanna, R B Suresh Kumar, Goutam Pramanik, Pallab K Haldar
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  ABSTRACT: Clerodendron infortunatum Linn. (Verbenaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India, which is traditionally used for several medicinal purposes. The aim of the present study was to evaluate the preclinical antihyperglycemic activity of the methanol extract of the leaves of C. infortunatum (MECI) in Wistar rats. Hyperglycemia was induced in rats by a single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with MECI intraperitoneally at the doses of 250 and 500 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as a reference drug. The fasting blood glucose levels were measured on every fifth day during the 15 days of treatment. Serum biochemical parameters such as glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, alkaline phosphatase, cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic lipid peroxidation, reduced glutathione (GSH), and catalase (CAT). MECI at the doses of 250 and 500 mg/kg intraperitoneally significantly (P<0.001) and dose-dependently reduced and normalized blood glucose levels as compared to that of the STZ control group. Serum biochemical parameters were significantly (P<0.001) restored towards normal levels in MECI-treated rats as compared to the STZ control. MECI treatment also significantly (P<0.001) decreased lipid peroxidation and recovered GSH levels and CAT activity towards normal values, as compared to the STZ control. The present study demonstrated that the leaves of C. infortunatum had remarkable preclinical antihyperglycemic activity in STZ-induced diabetic rats.
  Diabetes Therapy 05/2011; 2(2):92-100.
• Article: Are we in the polyphenols era?

  Sanjib Bhattacharya
  Pharmacognosy Research 04/2011; 3(2):147.
• Article: Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats

  Moulisha Biswas, Biswakanth Kar, Sanjib Bhattacharya, R.B. Suresh Kumar, Ashoke Kumar Ghosh, Pallab Kanti Haldar
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  ABSTRACT: Context: Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes.Objective: To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats.Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65  mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200  mg/kg body weight daily for 15 days. Glibenclamide (0.5  mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-day treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic lipid peroxidation, reduced glutathione (GSH), and catalase (CAT).Results and discussion: META at the dose of 100 and 200  mg/kg orally significantly (P  <  0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of STZ control group. Serum biochemical parameters were significantly (P  <  0.001) restored toward normal levels in META-treated rats as compared with STZ control. META treatment also significantly (P  <  0.001) decreased lipid peroxidation and recovered GSH level and CAT activity toward normal as compared with STZ control.Conclusion: The present study infers that T. arjuna leaf demonstrated remarkable antihyperglycemic activity in STZ-induced diabetic rats. The potential antihyperglycemic action is plausibly due to its underlying antioxidant role.
  Pharmaceutical Biology 03/2011; 49(4):335-340. · 0.88 Impact Factor
• Source

  Available from: Biswakanth Kar

  Article: Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats.

  Moulisha Biswas, Biswakanth Kar, Sanjib Bhattacharya, R B Suresh Kumar, Ashoke Kumar Ghosh, Pallab Kanti Haldar
  [show abstract] [hide abstract]
  ABSTRACT: Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes. To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats. Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-day treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic lipid peroxidation, reduced glutathione (GSH), and catalase (CAT). META at the dose of 100 and 200 mg/kg orally significantly (P < 0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of STZ control group. Serum biochemical parameters were significantly (P < 0.001) restored toward normal levels in META-treated rats as compared with STZ control. META treatment also significantly (P < 0.001) decreased lipid peroxidation and recovered GSH level and CAT activity toward normal as compared with STZ control. The present study infers that T. arjuna leaf demonstrated remarkable antihyperglycemic activity in STZ-induced diabetic rats. The potential antihyperglycemic action is plausibly due to its underlying antioxidant role.
  Pharmaceutical Biology 02/2011; 49(4):335-40. · 0.88 Impact Factor
• Article: Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats.

  Arvind Kumar, Sutharson Lingadurai, Tarani P Shrivastava, Sanjib Bhattacharya, Pallab K Haldar
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  ABSTRACT: Erythrina variegata Linn. (Fabaceae), commonly known as Tiger's Claw, is a thorny deciduous tree grown in tropical and subtropical regions of Eastern Africa, Southern Asia, and Northern Australia. In India, its leaves are traditionally used for diabetes mellitus. To evaluate the hypoglycemic activity of methanol extract of E. variegata leaf (MEEV) in streptozotocin (STZ)-induced diabetic Wistar rats. Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with MEEV orally at the doses of 300, 600, and 900 mg/kg body weight daily for 21 days. Glibenclamide (1 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every 7th day during the 21 days of treatment. Serum biochemical parameters including lipid content were estimated. MEEV at the doses of 300, 600, and 900 mg/kg orally significantly (P < 0.01) and dose-dependently reduced and normalized blood glucose levels as compared to that of STZ control group; the dose 900 mg/kg being the most potent showing complete normalization of blood glucose levels. Serum biochemical parameters including lipid profile were significantly (P < 0.01) restored toward normal levels in META-treated rats as compared to STZ control animals. This study concludes that E. variegata leaf demonstrated promising hypoglycemic action in STZ-induced diabetic rats substantiating its ethnomedicinal use.
  Pharmaceutical Biology 02/2011; 49(6):577-82. · 0.88 Impact Factor
• Article: Hepatoprotective Activity of Terminalia arjuna Leaf Against Paracetamol-Induced Liver Damage in Rats

  MOULISHA BISWAS, TARUN K. KARAN, BISWAKANTH KAR, SANJIB BHATTACHARYA, ASHOKE K. GHOSH, R.B. SURESH KUMAR, PALLAB K. HALDAR
  Asian Journal of Chemistry 01/2011; · 0.27 Impact Factor
• Article: Evaluation of hypoglycemic and antihyperglycemic effects of Luffa cylindrica fruit extract in rats

  Manjusha Hazra, Sriparna KunduSen, Sanjib Bhattacharya, Pallab K Haldar, Malaya Gupta, Upal K Mazumder
  Journal of Advanced Pharmacy Education & Research 01/2011;
• Source

  Available from: Jitendra Nath Pande

  Article: THIN LAYER CHROMATOGRAPHIC STUDIES AND IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF ANNONA SQUAMOSHA LEAF EXTRACTS

  Amartya Bose, Sanjib Bhattacharya, J. N. Pandey, Moulisha Biswas
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  ABSTRACT: Annona squamosa L. (Annonaceae), known as custard apple, is commonly found in deciduous forests and also cultivated in wild in various parts of India. The present study assessed the different solvent extracts of A. squamosa leaf for thin layer chromatography (TLC) and also evaluated their in vitro free radical scavenging potential by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The chloroform extract yielded maximum spots in TLC, followed by petroleum ether and methanol extracts respectively. All of the extracts exhibited potent in vitro free radical scavenging activity that increased with extract concentration. The methanol extract was found to be the most potent in this regard.
  Pharmacologyonline. 01/2011; 1:1223-1229.
• Source

  Available from: Jitendra Nath Pande

  Article: Anti-inflammatory activity of Syzygium cumini leaf against experimentally induced acute and chronic inflammations in rodents

  Anirban Roy, Sanjib Bhattacharya, Jitendra N. Pandey, Moulisha Biswas
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  ABSTRACT: Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as Jam in Bengali, Jamun in Hindi and Black Plum or Black Berry in English, is a large size evergreen tree indigenous to India and is cultivated for its fruits. In the present study, the methanol extract of leaves from S. cumini (MESC) was evaluated for anti-inflammatory activity in experimental acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced rat granuloma). In all the models, the MESC (100 and 200 mg/kg body wt. p.o.) exhibited significant antiinflammatory activity (P<0.001) in a dose dependent manner. These findings revealed that the S. cumini leaf had remarkable acute and chronic anti-inflammatory actions in the tested rodent models.
  Alternative Medicine Studies. 01/2011; 1:23-25.
• Article: acute and sub-chronic toxicity study of Terminalia arjuna leaf in swiss albino mice

  Moulisha Biswas, Tarun K Karan, Sanjib Bhattacharya, RB Suresh Kumar, Ashoke K Ghosh, Pallab K Halda
  Pharmacologyonline. 01/2011;