S.M. Humphreys

The University of Sheffield, Sheffield, England, United Kingdom

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Publications (1)1.74 Total impact

  • Source
    Y.H. Guan · T de Graaf · D.L. Lath · S.M. Humphreys · I Marlow · A.H. Brook
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    ABSTRACT: A microtitre assay has been developed using hydroxyapatite-coated wells and Streptococcus sanguis NCTC 10904 at 10(7) cells per ml. A number of models representing toothpaste and mouthwash usage were adopted to detect the anti-adherent efficacy of a polyvinylmethylether maleic acid copolymer (PVM/MA), polyoxypropylene/polyoxyethylene block copolymer (PO/EO), two casein-derived peptides and selected silicones. The results not only confirmed the anti-adherence property of the selected components but also indicated possible molecular interactions leading to the observed performance. To account for the diversity of oral microbial cells in vivo, a further testing system was developed. This involved submerging a hydroxyapatite disc in a mixed culture of human salivary microbial cells, and exposing it to different treatments using the active component either in an aqueous dispersion or in a toothpaste. The effect of toothpastes containing PO/EO, dimethicone copoyol or PVM/MA was investigated over a 4-h incubation with microflora. These tests showed that in a toothpaste formulation the anti-adherent efficacy may be reduced when compared with an aqueous dispersion containing the same or nearly the same concentration of the active component.
    Archives of Oral Biology 03/2001; 46(2):129-38. DOI:10.1016/S0003-9969(00)00105-9 · 1.74 Impact Factor

Publication Stats

9 Citations
1.74 Total Impact Points

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  • 2001
    • The University of Sheffield
      • School of Clinical Dentistry
      Sheffield, England, United Kingdom