S A Zargar

Sher-i-Kashmir Institute of Medical Sciences, Suryanagar, Kashmir, India

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Publications (97)348.61 Total impact

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    ABSTRACT: Background: Phospholipase C epsilon 1 (PLCE1) encodes a member of the phospholipase family of proteins that play crucial roles in carcinogenesis and progression of several cancers including esophageal cancer (EC). In two large scale genome-wide association studies (GWAS) single nucleotide polymorphisms (SNP, rs2274223A>G, rs3765524C>T) in PLCE1 were identified as novel susceptibility loci of esophageal cancer (EC) in China. The aim of the present study was to investigate this finding in Kashmir Valley, a high risk area. Materials and Methods: We determined genotypes of three potentially functional SNPs (rs2274223A>G, rs3765524C>T and rs7922612C>T) of PLCE1 in 135 EC patients, and 195 age and gender matched controls in Kashmiri valley by PCR RFLP method. Risk for developing EC was estimated by binary logistic regression using SPSS. Results: The selected PLCE1 polymorphisms did not show independent association with EC. However, the G2274223T3765524T7922612 haplotype was significantly associated with increased risk of EC (OR=2.92; 95% CI=1.30-6.54; p=0.009). Smoking and salted tea proved to be independent risk factors for EC. Conclusions: Genetic variations in PLCE1 modulate risk of EC in the high risk Kashmiri population.
    Asian Pacific journal of cancer prevention: APJCP 01/2014; 15(10):4319-23. · 1.27 Impact Factor
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    ABSTRACT: AbstrAct Aims: Idiopathic pancreatitis may be diagnosed once all causes of pancreatitis are excluded by thorough history, metabolic profile and conventional imaging modality, i.e., abdominal ultrasonography. In this study, we have attempted to evaluate the cause of idiopathic pancreatitis with the help of magnetic resonance cholangiopancreatography (MrcP). Methods: Fifty patients presenting with idiopathic pancreatitis were assessed prospectively using MrcP with strength 1.5 tesla for potential cause of the attack of pancreatitis. results: Magnetic resonance cholangiopancreatography was able to establish the cause of pancreatitis in eleven (22%) patients, as follows. common bile duct stone in one (2%), pancreatic divisum in one (2%), gallbladder stone in one (2%), pancreatic duct stone in one (2%), chronic pancreatitis in two (4%), gallbladder sludge in two (4%) and anomalous pancreaticobiliary union in three (6%) patients. conclusion: Magnetic resonance cholangiopancreatography, a non-invasive and complication free imaging modality is able to establish the cause of acute pancreatitis in patients in whom the diagnosis of idiopathic pancreatitis has been made following standard investigations. Idiopathic pancreatitis should not be diagnosed unless MrcP has been performed.. The efficacy of magnetic resonance cholangiopancreatography in assessing the etiology of acute idiopathic pancreatitis. Int J Hepatobiliary Pancreat Dis 2014;4:32–39.
    01/2014; 44:32-39.
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    ABSTRACT: Background and study aims Endoscopic sphincterotomy (ES) is one of the most important advances in the treatment of common bile duct (CBD) stones. However, the use of ES to remove CBD stones in high-risk patients without cholecystectomy is still debatable. The aim of this study was to compare the efficacy of a wait-and-see policy versus cholecystectomy after ES for CBD stones in high-risk patients with co-existing cholelithiasis. Patients and methods A total of 162 patients after undergoing ES with the clearance of CBD stones were randomised after informed consent to cholecystectomy or conservative management of their gallbladder stones. Results The results indicated that cholecystectomy after ES for CBD stones significantly reduced the biliary complications in high-risk patients. Conclusion Every patient who has both CBD stones and gallstones with significant co-morbid illnesses, after clearance of CBD stones by ES, should undergo early cholecystectomy.
    Arab Journal of Gastroenterology 01/2014;
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    ABSTRACT: AbstrAct Aims: Idiopathic pancreatitis may be diagnosed once all causes of pancreatitis are excluded by thorough history, metabolic profile and conventional imaging modality, i.e., abdominal ultrasonography. In this study, we have attempted to evaluate the cause of idiopathic pancreatitis with the help of magnetic resonance cholangiopancreatography (MrcP). Methods: Fifty patients presenting with idiopathic pancreatitis were assessed prospectively using MrcP with strength 1.5 tesla for potential cause of the attack of pancreatitis. results: Magnetic resonance cholangiopancreatography was able to establish the cause of pancreatitis in eleven (22%) patients, as follows. common bile duct stone in one (2%), pancreatic divisum in one (2%), gallbladder stone in one (2%), pancreatic duct stone in one (2%), chronic pancreatitis in two (4%), gallbladder sludge in two (4%) and anomalous pancreaticobiliary union in three (6%) patients. conclusion: Magnetic resonance cholangiopancreatography, a non-invasive and complication free imaging modality is able to establish the cause of acute pancreatitis in patients in whom the diagnosis of idiopathic pancreatitis has been made following standard investigations. Idiopathic pancreatitis should not be diagnosed unless MrcP has been performed.. The efficacy of magnetic resonance cholangiopancreatography in assessing the etiology of acute idiopathic pancreatitis. Int J Hepatobiliary Pancreat Dis 2014;4:32–39.
    01/2014; 44:32-39.
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    ABSTRACT: AbstrAct Aims: Idiopathic pancreatitis may be diagnosed once all causes of pancreatitis are excluded by thorough history, metabolic profile and conventional imaging modality, i.e., abdominal ultrasonography. In this study, we have attempted to evaluate the cause of idiopathic pancreatitis with the help of magnetic resonance cholangiopancreatography (MrcP). Methods: Fifty patients presenting with idiopathic pancreatitis were assessed prospectively using MrcP with strength 1.5 tesla for potential cause of the attack of pancreatitis. results: Magnetic resonance cholangiopancreatography was able to establish the cause of pancreatitis in eleven (22%) patients, as follows. common bile duct stone in one (2%), pancreatic divisum in one (2%), gallbladder stone in one (2%), pancreatic duct stone in one (2%), chronic pancreatitis in two (4%), gallbladder sludge in two (4%) and anomalous pancreaticobiliary union in three (6%) patients. conclusion: Magnetic resonance cholangiopancreatography, a non-invasive and complication free imaging modality is able to establish the cause of acute pancreatitis in patients in whom the diagnosis of idiopathic pancreatitis has been made following standard investigations. Idiopathic pancreatitis should not be diagnosed unless MrcP has been performed.. The efficacy of magnetic resonance cholangiopancreatography in assessing the etiology of acute idiopathic pancreatitis. Int J Hepatobiliary Pancreat Dis 2014;4:32–39.
    01/2014; 44:32-39.
  • [Show abstract] [Hide abstract]
    ABSTRACT: AbstrAct Aims: Idiopathic pancreatitis may be diagnosed once all causes of pancreatitis are excluded by thorough history, metabolic profile and conventional imaging modality, i.e., abdominal ultrasonography. In this study, we have attempted to evaluate the cause of idiopathic pancreatitis with the help of magnetic resonance cholangiopancreatography (MrcP). Methods: Fifty patients presenting with idiopathic pancreatitis were assessed prospectively using MrcP with strength 1.5 tesla for potential cause of the attack of pancreatitis. results: Magnetic resonance cholangiopancreatography was able to establish the cause of pancreatitis in eleven (22%) patients, as follows. common bile duct stone in one (2%), pancreatic divisum in one (2%), gallbladder stone in one (2%), pancreatic duct stone in one (2%), chronic pancreatitis in two (4%), gallbladder sludge in two (4%) and anomalous pancreaticobiliary union in three (6%) patients. conclusion: Magnetic resonance cholangiopancreatography, a non-invasive and complication free imaging modality is able to establish the cause of acute pancreatitis in patients in whom the diagnosis of idiopathic pancreatitis has been made following standard investigations. Idiopathic pancreatitis should not be diagnosed unless MrcP has been performed.. The efficacy of magnetic resonance cholangiopancreatography in assessing the etiology of acute idiopathic pancreatitis. Int J Hepatobiliary Pancreat Dis 2014;4:32–39.
    01/2014; 44:32-39.
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    ABSTRACT: Genetic alterations in the deleted in colorectal carcinoma (DCC) gene have been a priori reported to associate with metastasis in variety of human cancers. We investigated the association between potentially functional SNPs in DCC and susceptibility to esophageal (EC) and gastric (GC) cancers in Kashmir Valley. We genotyped two SNPs DCC rs714 (A>G) and DCC rs2229080 (C>G) of DCC in 135 EC patients, 108 GC patients, and 195 controls matched by age and sex in Kashmir Valley by polymerase chain reaction-RFLP method. Risk for developing EC and GC was estimated by binary logistic regression by using SPSS. We also performed a meta-analysis on DCC rs714 (A>G) and evaluated the association between the DCC rs714 (A>G) polymorphisms and cancer risk. A significant difference in DCC rs714 (A>G) genotype distribution between EC and GC cases and corresponding control groups was observed (odds ratio (OR) = 1.92; P = 0.03; P-trend = 0.04; false discovery rate (FDR) Pcorr = 0.03: OR = 2.15; P = 0.02; P-trend = 0.01; FDR Pcorr = 0.03). But no such association was observed in DCC rs2229080 (C>G). Further, DCC rs714 (A>G) AA genotype showed significantly increased risk for both gastric squamous cell carcinoma (OR = 5.63; P = 0.02; FDR Pcorr = 0.01) and gastric adenocarcinoma (OR = 2.15; P = 0.02; FDR Pcorr = 0.01). Smoking and salted tea are independently associated with both EC and GC, but gene-environment interaction did not further modulate the risk. Meta-analysis also suggested both independent and overall association of DCC rs714 (A>G) polymorphism with cancer (P = 0.000). In conclusion, genetic variations in DCC rs714 (A>G) modulate risk of EC and GC in high-risk Kashmir population.
    Tumor Biology 06/2013; · 2.52 Impact Factor
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    Manzoor Ahmad Malik, Showkat Ali Zargar, Balraj Mittal
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    Manzoor Ahmad Malik, Showkat Ali Zargar, Balraj Mittal
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    ABSTRACT: Studies have persistently associated esophageal squamous cell carcinoma (ESCC) risk with low socioeconomic status (SES), but this association is unexplored in Kashmir, an area with a high incidence of ESCC in the northernmost part of India. We conducted a case-control study to assess the association of multiple indicators of SES and ESCC risk in Kashmir valley. A total number of 703 histologically confirmed ESCC cases and 1664 controls matched to the cases for age, sex, and district of residence were recruited from October, 2008 to January, 2012. Conditional logistic regression models were used to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). Composite wealth scores were constructed based on the ownership of several appliances using multiple correspondence analysis. Higher education, living in the kiln brick or concrete house, use of liquefied petroleum gas and electricity for cooking, and higher wealth scores all showed an inverse association with ESCC risk. Compared to farmers, the individuals who had government jobs and worked in the business sector were at lower risk of ESCC, but this association disappeared in fully adjusted models. Occupational strenuous physical activity was strongly associated with ESCC risk. In summary, we found a strong relationship of low SES and ESCC in Kashmir. The findings need to be studied further to understand the mechanisms through which such SES parameters increase ESCC risk. This article is protected by copyright. All rights reserved.
    Cancer Science 05/2013; · 3.48 Impact Factor
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    ABSTRACT: BACKGROUND: Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case–control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ESCC are common, to investigate the association of hookah smoking, nass use, and several other habits with ESCC. METHODS: We recruited 702 histologically confirmed ESCC cases and 1663 hospital-based controls, individually matched to the cases for age, sex, and district of residence from September 2008 to January 2012. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Ever-hookah smoking (OR¼1.85; 95% CI, 1.41–2.44) and nass chewing (OR¼2.88; 95% CI, 2.06–4.04) were associated with ESCC risk. These associations were consistent across different measures of use, including intensity, duration, and cumulative amount of use, and after excluding ever users of the other product and cigarette smokers. Our results also suggest an increased risk of ESCC associated with ever-gutka chewing and -bidi smoking. However, the latter associations were based on small number of participants. CONCLUSION: This study shows that hookah and nass use are associated with ESCC risk. As prevalence of hookah use seems to be increasing among young people worldwide, these results may have relevance not only for the regions in which hookah use has been a traditional habit, but also for other regions, including western countries. British Journal of Cancer (2012) 0, 000–000. doi:10.1038/bjc.2012.449 www.bjcancer.com & 2012 Cancer Research UK Keywords: oesophageal cancer; hookah; nass; smoking; tobacco
    British Journal of Cancer 04/2013; 108(7):1552. · 5.08 Impact Factor
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    ABSTRACT: BACKGROUND: Increasing resistance against Helicobacter pylori has resulted in reduced eradication rates. OBJECTIVE: This study aims to determine whether eradication rates for H. pylori infection with sequential therapy is better than standard triple therapy. PATIENTS: Patients with endoscopy documented peptic ulcer and H. pylori infection confirmed by histology and rapid urease test. INTERVENTION: Patients were randomized into two groups; 134 received standard triple therapy (pantoprazole 40 mg, clarithromycin 500 mg and amoxicillin 1 g each administered twice daily) for 10 days and 138 received sequential regimen (pantoprazole 40 mg plus amoxicillin 1 g twice daily for 5 days followed by 40 mg pantoprazole, 500 mg clarithromycin, and 500 mg tinidazole each administered twice daily for 5 days). Eradication was confirmed by histology and rapid urease test. Compliance and adverse effects were determined by the recovery of empty medicine strips and questioning. RESULTS: The eradication rates with sequential therapy were significantly greater than with standard therapy on both intention-to-treat analysis (76.0 % vs. 61.9 %, p = 0.005; difference, 14.1 % [95 % CI, 6.5-19 %] and per protocol analysis (84.6 % vs. 67.4 %, p = 0.002; difference, 17.2 % [95 % CI, 8.5-23.5 %]). The incidence of side effects did not differ between the two therapy groups. One patient in standard therapy discontinued treatment due to side effects. LIMITATION: Cultures were not performed. Loss to follow up was 5.2 % in standard therapy and 6.5 % in sequential therapy. CONCLUSION: Sequential therapy was significantly more effective than standard therapy for eradicating H. pylori infection in peptic ulcer disease in Asian patients. Side effects were similar.
    Indian Journal of Gastroenterology 03/2013;
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    ABSTRACT: BACKGROUND: Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H pylori on symptoms of functional dyspepsia is uncertain and the data in Asian scenario is scanty. OBJECTIVE: To see H pylori positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms. STUDY DESIGN: Randomized, double blind, placebo controlled study. METHODS: Patients of functional dyspepsia defined as per Rome 2 criteria were tested for H pylori infection by rapid urease test and gastric biopsy. H Pylori positive patients were randomly allocated to Triple therapy (20mg omeprazole, 500mg of clarithromycin and 1000mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly Likert's scale. RESULTS: H pylori positivity rate in functional dyspepsia was 1160/2000 (58%). At 6 weeks the eradication rate for H Pylori in triple therapy and placebo group was [181/259(69.8%) and 13/260(5.0%) p=0.001] respectively. On intention to treat analysis, the symptom resolution at one month was [157/259(60.7%) and 136/260(52.3%), p=0.38] respectively. At 12 months, H Pylori eradication and healing of gastritis in triple therapy and placebo group was [116/174(66.7%) and 12/180 (6.7%) p=0.001] and [132/174(75.9%) and 11/180(6.1%), p=0.001] respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was [95/217(43.7%) and 72/195(36.9%) p=0.13] Conclusion: There is high H Pylori positivity rate in patients of functional dyspepsia. The eradication of H Pylori does not resolve the symptoms, despite healing of gastritis.
    Journal of Gastroenterology and Hepatology 02/2013; · 3.33 Impact Factor
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    ABSTRACT: BACKGROUND: The purpose of the present study was to determine the etiology, management, and outcome of acute pancreatitis (AP) in children in an endemic area of hepatobiliary ascariasis (HBA). METHODS: This was a prospective, hospital-based study over a 9-year period that included 156 children younger than 12 years of age who had a diagnosis of AP. RESULTS: Of the 156 patients, 71 were boys and 85 were girls with a mean age of 8.4 ± 1.5 years (range 3-12 years). The various factors contributing to AP were biliary ascariasis in 93 cases (60 %), gallstones 16 (10 %), trauma 5 (3 %), choledochal cyst 4 (3 %), impacted bile duct stone 3 (2 %), and gallbladder sludge 2 (1 %). Idiopathic group 33 cases (21 %). Diagnosis was based on clinical picture, abdominal ultrasonography, and elevated serum amylase level. Pancreatitis was mild in 113 (72 %) patients and severe in 43 (28 %). With conservative therapy, 123 patients (79 %) improved, whereas the remaining 33, who had intractable abdominal pain, cholangitis, or worsening cholecystitis, underwent emergency endoscopic retrograde cholangiopancreatography for removal of worms (26 patients) and stones in the bile duct (7 patients). Bile duct stones were extracted in all 7 patients with that condition, and worms were extracted from 23 of the 26 patients with ascariasis. Emergency surgery was performed in five patients. Three patients died. Pancreatitis recurred in 16 patients due to HBA. CONCLUSIONS: Pancreatitis is not uncommon in children. Ascariasis is a leading cause of AP in endemic areas. Patients usually respond to conservative management, but endoscopic treatment is effective. Surgery is rarely required.
    World Journal of Surgery 02/2013; · 2.23 Impact Factor
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    ABSTRACT: BACKGROUND AND OBJECTIVES: There is no ideal therapy for eradication of Helicobacter pylori infection. We evaluated the efficacy and safety of 1-week triple therapy with rabeprazole, levofloxacin, and tinidazole in a metronidazole resistance prevalent region for eradicating H. pylori infection in patients with gastroduodenal ulcers. METHODS: This was an open-label, prospective study. Consecutive patients with endoscopy-proven duodenal or gastric ulcer and who were H. pylori-positive were treated with levofloxacin 500 mg once a day, rabeprazole 20 mg twice a day, and tinidazole 500 mg twice daily for 7 days followed by rabeprazole 20 mg OD for 8 weeks. Endoscopy was repeated 8 weeks after the end of therapy to check for ulcer healing and H. pylori status. RESULTS: One hundred and thirty-one patients with gastroduodenal ulcers (duodenal 118, and gastric 13) were included. Drug compliance was 97.7 %. The eradication rate of H. pylori by intention-to-treat analysis was 85.5 % (95 % confidence interval 79.5-91.5) (112 of 131 patients) and by per-protocol analysis was 91.8 % (95 % confidence interval 86.9-96.7) (112 of 122 patients). Adverse effects were reported in 17 %: abdominal pain in 3.05 %, metallic taste in 6.87 %, and nausea and vomiting in 4.58 %. CONCLUSIONS: Levofloxacin-tinidazole-based triple therapy was highly effective and safe as a first-line regimen in Indian patients with gastroduodenal ulcer disease associated with H. pylori infection. The regimen was well tolerated.
    Indian Journal of Gastroenterology 12/2012;
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    North American journal of medical sciences. 11/2012; 4(11):613-4.
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    ABSTRACT: Background:  Hepatolithiasis affecting the left hepatobiliary system is common in the Asia Pacific region. This aim of this study was to describe an experience with the diagnosis and treatment of patients with isolated left-sided hepatolithiasis. Methods:  One hundred and ten patients with isolated left-sided hepatolithiasis who underwent a left-sided hepatic resection between January 1999 and February 2010 were included for further analysis. The clinical profile, cholangiograms, operative procedures and early and late results were examined. Results:  Analysis of magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) findings revealed left hepatic ductal anatomical details in 101 patients. Three types of left hepatic ductal variations were observed (type 1 in 90.1%, type 2 in 5.9% and type 3 in 4.0% patients). Eighty-four (76.4%) patients had the presence of strictures in the left hepatic ductal system and in 26 (23.6%) patients no strictures could be seen. Out of 84 patients with strictures, 78 could be classified (type I in 89.7% and type II in 10.3%). Of the 110 patients, 75 (68.2%) underwent a left lateral sectionectomy, 33 (30%) a left hepatectomy and 2 (1.8%) patients were treated with a left hepatectomy combined with a caudate lobe resection. Of the patients who underwent a left hepatectomy 11.4% developed a bile leak. Eight per cent of patients who underwent a left lateral sectionectomy had infective complications. During a median follow-up period of 63 (range 3-134) months, 2 (2.1%) patients were discovered to have residual stones and five (5.2%) others possessed recurrent stones. Conclusions:  This study highlights the impact of the presence or absence of bile duct stricture on the clinical and histological profile of patients as well as their operative and the post-operative behaviour. It is concluded that hepatic resection is an appropriate treatment modality in localized left-sided hepatolithiasis.
    HPB 11/2012; 14(11):764-71. · 1.94 Impact Factor
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    ABSTRACT: Background:Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case-control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ESCC are common, to investigate the association of hookah smoking, nass use, and several other habits with ESCC.Methods:We recruited 702 histologically confirmed ESCC cases and 1663 hospital-based controls, individually matched to the cases for age, sex, and district of residence from September 2008 to January 2012. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs).Results:Ever-hookah smoking (OR=1.85; 95% CI, 1.41-2.44) and nass chewing (OR=2.88; 95% CI, 2.06-4.04) were associated with ESCC risk. These associations were consistent across different measures of use, including intensity, duration, and cumulative amount of use, and after excluding ever users of the other product and cigarette smokers. Our results also suggest an increased risk of ESCC associated with ever-gutka chewing and -bidi smoking. However, the latter associations were based on small number of participants.Conclusion:This study shows that hookah and nass use are associated with ESCC risk. As prevalence of hookah use seems to be increasing among young people worldwide, these results may have relevance not only for the regions in which hookah use has been a traditional habit, but also for other regions, including western countries.
    British Journal of Cancer 10/2012; 107(9):1618-23. · 5.08 Impact Factor
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    ABSTRACT: BACKGROUND: Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case–control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ESCC are common, to investigate the association of hookah smoking, nass use, and several other habits with ESCC. METHODS: We recruited 702 histologically confirmed ESCC cases and 1663 hospital-based controls, individually matched to the cases for age, sex, and district of residence from September 2008 to January 2012. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Ever-hookah smoking (OR¼1.85; 95% CI, 1.41–2.44) and nass chewing (OR¼2.88; 95% CI, 2.06–4.04) were associated with ESCC risk. These associations were consistent across different measures of use, including intensity, duration, and cumulative amount of use, and after excluding ever users of the other product and cigarette smokers. Our results also suggest an increased risk of ESCC associated with ever-gutka chewing and -bidi smoking. However, the latter associations were based on small number of participants. CONCLUSION: This study shows that hookah and nass use are associated with ESCC risk. As prevalence of hookah use seems to be increasing among young people worldwide, these results may have relevance not only for the regions in which hookah use has been a traditional habit, but also for other regions, including western countries.
    British Journal of Cancer 09/2012; · 5.08 Impact Factor
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    Manzoor Ahmad Malik, Showkat Ali Zargar, Balraj Mittal
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    ABSTRACT: Esophageal cancer (EC) is a complex multifactorial disorder, where environmental and genetic factors play major role. NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. A case-control study was performed to investigated the associations of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC in a high-risk Kashmiri population of India in 135 EC patients and 195 unrelated healthy controls using PCR-RFLP. We also performed a meta analysis of nine published studies (1,224 cases and 1,740 controls) on NQO1 609C>T and evaluated the association between the NQO1 609C>T polymorphisms and esophageal cancer risk. A significant difference in NQO1 609C>T and NQO2 -3423G>A genotype distribution between EC cases and corresponding controls groups was observed (OR = 2.65; 95 % CI = 1.29-5.42 and OR = 1.88; 95 % CI = 1.02-3.49 respectively). Further, gene-gene interaction showed significantly increased risk for esophageal adenocarcinoma with variant genotypes of NQO1 609C>T and NQO2 -3423G>A polymorphisms and interaction with environmental risk factors revealed pronounced risk of EC with NQO1 609C>T TT genotype in high salted tea users of Kashmir valley (OR = 3.72, 95 % CI = 0.98-14.19). Meta analysis of NQO 609C>T polymorphism also suggested association of the polymorphism with EC in Asians as well as Europeans. In conclusion, NQO1 609C>T and NQO2 -3423G>A genetic variations modulate risk of EC in high-risk Kashmir population.
    Molecular Biology Reports 06/2012; 39(9):9095-104. · 2.51 Impact Factor

Publication Stats

1k Citations
348.61 Total Impact Points

Institutions

  • 1991–2014
    • Sher-i-Kashmir Institute of Medical Sciences
      • Department of Gastroenterology
      Suryanagar, Kashmir, India
  • 2010–2013
    • Sanjay Gandhi Post Graduate Institute of Medical Sciences
      Lakhnau, Uttar Pradesh, India
  • 2012
    • University of Kashmir
      • Department of Biochemistry
      Suryanagar, Kashmir, India